Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model

• Published in: Scientific reports Vol. 11; no. 1; p. 18398
• Main Authors: Kashiwagi, Yoichiro, Aburaya, Shunsuke, Sugiyama, Naoyuki, Narukawa, Yuki, Sakamoto, Yuta, Takahashi, Masatomo, Uemura, Hayato, Yamashita, Rentaro, Tominaga, Shotaro, Hayashi, Satoko, Nozaki, Takenori, Yamada, Satoru, Izumi, Yoshihiro, Kashiwagi, Atsunori, Bamba, Takeshi, Ishihama, Yasushi, Murakami, Shinya
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/2565/2134; 631/326/46; 631/61/320; 631/61/475; 692/699/2743/137/773; 692/699/3020/3029; Alveolar bone; Animals; Biological Therapy; Biomarkers; Blood Glucose; Bone resorption; Culture Media, Conditioned - metabolism; Culture Media, Conditioned - pharmacology; Cytokines; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Digestive system; Disease Models, Animal; Dysbiosis - complications; Dysbiosis - microbiology; Energy Metabolism; Fasting; Gastrointestinal Microbiome; Gastrointestinal tract; Gluconeogenesis; Glucose metabolism; Humanities and Social Sciences; Hyperglycemia; Inflammation; Insulin; Insulin - blood; Insulin resistance; Intestinal microflora; Intestine; Laboratory testing; Liver; Localization; Metabolic Diseases - etiology; Metabolic Diseases - metabolism; Metabolism; Metabolites; Mice; Microbiomes; Microbiota; multidisciplinary; Oral administration; Peptides; Peptides - metabolism; Peptides - pharmacology; Periodontitis - complications; Periodontitis - metabolism; Periodontitis - microbiology; Periodontitis - therapy; Porphyromonas gingivalis; Porphyromonas gingivalis - physiology; Proteomes; Science; Science (multidisciplinary)

Periodontal infection induces systemic inflammation; therefore, aggravating diabetes. Orally administered periodontal pathogens may directly alter the gut microbiota. We orally treated obese db / db diabetes mice using Porphyromonas gingivalis ( Pg ). We screened for Pg -specific peptides in the int...