Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma - Ganesa, Sachita; Sule, Amrita; Sundaram, Ranjini K.; Bindra, Ranjit S. (Scientific reports, 2022)
Keywords: 631/154; 631/67; Alkylation; Antineoplastic Agents, Alkylating - pharmacology; Antineoplastic Agents, Alkylating - therapeutic use; Ataxia telangiectasia; Ataxia telangiectasia mutated protein; Ataxia Telangiectasia Mutated Proteins - genetics; Ataxia Telangiectasia Mutated Proteins - metabolism; Brain cancer; Cell activation; DNA methylation; DNA Mismatch Repair - genetics; DNA Modification Methylases - genetics; DNA Modification Methylases - metabolism; DNA Repair Enzymes - genetics; DNA Repair Enzymes - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Glioblastoma; Glioblastoma - drug therapy; Glioblastoma - genetics; Glioblastoma cells; Humanities and Social Sciences; Humans; Lesions; Methylation; Methylguanine; Methyltransferases - metabolism; Mismatch repair; Mismatch Repair Endonuclease PMS2 - genetics; MLH1 protein; MSH2 protein; MSH6 protein; multidisciplinary; MutL Protein Homolog 1 - genetics; MutL Protein Homolog 1 - metabolism; MutS Homolog 2 Protein - genetics; O6-methylguanine-DNA methyltransferase; Proteins; Science; Science (multidisciplinary); Temozolomide; Temozolomide - pharmacology; Temozolomide - therapeutic use; Tumor Suppressor Proteins - metabolism; Tumors