Construction and analysis of a ceRNA network and patterns of immune infiltration in chronic rhinosinusitis with nasal polyps: based on data mining and experimental verification

• Published in: Scientific reports Vol. 12; no. 1; pp. 9735 - 17
• Main Authors: Chen, Jing-cai, Xing, Qi-long, Yang, Hui-wen, Yang, Fan, Luo, Yao, Kong, Wei-jia, Wang, Yan-jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.06.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/2114; 631/250/256/2515; 692/420/256/2515; 692/53/2421; Bioinformatics; Data Mining; Dendritic cells; Gene expression; Gene Regulatory Networks; Humanities and Social Sciences; Humans; Immunofluorescence; Immunohistochemistry; Infiltration; Interferon regulatory factor 4; Leukocytes (eosinophilic); Macrophages; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; multidisciplinary; Nasal Polyps - genetics; Non-coding RNA; Polyps; Rhinitis; Rhinosinusitis; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; Science; Science (multidisciplinary); Sinusitis; Therapeutic targets
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-13818-6

Recent studies have revealed the significant role of the competing endogenous RNA (ceRNA) network in human diseases. However, systematic analysis of the ceRNA mechanism in chronic rhinosinusitis with nasal polyps (CRSwNP) is limited. In this study, we constructed a competitive endogenous RNA (ceRNA)...