Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression

• Published in: Molecular psychiatry Vol. 13; no. 7; pp. 709 - 716
• Main Authors: Pezawas, L, Meyer-Lindenberg, A, Goldman, A L, Verchinski, B A, Chen, G, Kolachana, B S, Egan, M F, Mattay, V S, Hariri, A R, Weinberger, D R
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2008; Nature Publishing Group
• Subjects: Adult and adolescent clinical studies; Alleles; Amino Acid Substitution; Amygdala; Anxiety; Behavioral Sciences; Biological and medical sciences; Biological Psychology; Brain; Brain - pathology; Brain-derived neurotrophic factor; Brain-Derived Neurotrophic Factor - genetics; Care and treatment; Depression; Depression - genetics; Depression - pathology; Depression, Mental; Depressive Disorder - genetics; Depressive Disorder - pathology; Diagnosis; Epistasis; Epistasis, Genetic; European Continental Ancestry Group - genetics; Genes; Genetic aspects; Genetic disorders; Genetic engineering; Genetic epistasis; Gyrus Cinguli - pathology; Health aspects; Humans; Magnetic Resonance Imaging; Medical imaging; Medical sciences; Medicine; Medicine & Public Health; Mental depression; Mental health; Mood disorders; Neural networks; Neurogenesis; Neuroimaging; Neuromodulation; Neurosciences; Neurotrophic functions; original-article; Pharmacotherapy; Physiological aspects; Polymorphism, Genetic; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychosis; Reference Values; Risk factors; Serotonin; Serotonin Plasma Membrane Transport Proteins - genetics; Social interactions; Stress; United States; United States > US; anxiety; depression; 5-HTTLPR; BDNF; neurotrophins; neuroimaging; Mood disorder; Neurotrophin; Affect affectivity; Depression; Anxiety; Brain derived neurotrophic factor

Complex genetic disorders such as depression likely exhibit epistasis, but neural mechanisms of such gene–gene interactions are incompletely understood. 5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter ( SLC6A4 ) and brain-derived neurotrophic factor ( BDNF )...