Real-time interleaved spectroscopic photoacoustic and ultrasound (PAUS) scanning with simultaneous fluence compensation and motion correction

• Published in: Nature communications Vol. 12; no. 1; pp. 716 - 12
• Main Authors: Jeng, Geng-Shi, Li, Meng-Lin, Kim, MinWoo, Yoon, Soon Joon, Pitre, John J., Li, David S., Pelivanov, Ivan, O’Donnell, Matthew
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.01.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 59; 631/1647/245/1859; 631/1647/245/2160; 631/1647/245/2226; 639/166/985; Animal models; Animals; Clinical trials; Compensation; Computer Systems; Drug delivery; Drug delivery systems; Equipment Design; Female; Fiber optics; Fluence; Humanities and Social Sciences; Image processing; Image Processing, Computer-Assisted; Image reconstruction; Laser beams; Lasers; Mice; Mice, Nude; Models, Animal; Molecular Imaging - instrumentation; Molecular Imaging - methods; Motion; multidisciplinary; Optical Fibers; Phantoms, Imaging; Photoacoustic Techniques - instrumentation; Photoacoustic Techniques - methods; Real time; Science; Science (multidisciplinary); Spectroscopy; Spectrum Analysis - instrumentation; Spectrum Analysis - methods; Tunable lasers; Ultrasonic imaging; Ultrasonography - instrumentation; Ultrasonography - methods; Ultrasound; Variation; Wavelength; United States > US

For over two decades photoacoustic imaging has been tested clinically, but successful human trials have been limited. To enable quantitative clinical spectroscopy, the fundamental issues of wavelength-dependent fluence variations and inter-wavelength motion must be overcome. Here we propose a real-t...