Validation of MRI quantitative susceptibility mapping of superparamagnetic iron oxide nanoparticles for hyperthermia applications in live subjects

• Published in: Scientific reports Vol. 10; no. 1; p. 1171
• Main Authors: Deh, Kofi, Zaman, Marjan, Vedvyas, Yogindra, Liu, Zhe, Gillen, Kelly McCabe, O’ Malley, Padraic, Bedretdinova, Dina, Nguyen, Thanh, Lee, Richard, Spincemaille, Pascal, Kim, Juyoung, Wang, Yi, Jin, Moonsoo M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.01.2020; Nature Publishing Group
• Subjects: 59/57; 59/78; 631/67/1059/602; 639/166/985; 64/60; 692/700/565; 82/51; Adenocarcinoma - diagnostic imaging; Adenocarcinoma - pathology; Adenocarcinoma - therapy; Animals; Cancer therapies; Cell death; Cell Line, Tumor; Contrast Media; Ferric Compounds - analysis; Ferric Compounds - pharmacokinetics; Ferric Compounds - therapeutic use; Ferrosoferric Oxide - analysis; Ferrosoferric Oxide - pharmacokinetics; Ferrosoferric Oxide - therapeutic use; Histology; Humanities and Social Sciences; Hyperthermia; Hyperthermia, Induced; Image Processing, Computer-Assisted; Injection; Iron oxides; Localization; Magnetic fields; Magnetic Resonance Imaging; Male; Mapping; Mice; Mice, Inbred NOD; multidisciplinary; Nanoparticles; Nanoparticles - analysis; Nanoparticles - therapeutic use; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms - pathology; Radioisotopes; Radiopharmaceuticals; Science; Science (multidisciplinary); Subcutaneous Tissue; Tissue Distribution; Tumor Burden; Tumors; Xenograft Model Antitumor Assays; Zirconium
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-58219-9

The use of magnetic fluid hyperthermia (MFH) for cancer therapy has shown promise but lacks suitable methods for quantifying exogenous irons such as superparamagnetic iron oxide (SPIO) nanoparticles as a source of heat generation under an alternating magnetic field (AMF). Application of quantitative...