Frontoparietal connectivity correlates with working memory performance in multiple sclerosis

Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit,...

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Published inScientific reports Vol. 10; no. 1; pp. 9310 - 13
Main Authors Figueroa-Vargas, Alejandra, Cárcamo, Claudia, Henríquez-Ch, Rodrigo, Zamorano, Francisco, Ciampi, Ethel, Uribe-San-Martin, Reinaldo, Vásquez, Macarena, Aboitiz, Francisco, Billeke, Pablo
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 09.06.2020
Nature Publishing Group
Nature Portfolio
Subjects
631/378/2649
692/617/375/1411/1666
Adult
Case-Control Studies
Cognitive ability
EEG
Electroencephalography
Female
Frontal Lobe - diagnostic imaging
Frontal Lobe - physiopathology
Humanities and Social Sciences
Humans
Image Processing, Computer-Assisted
Male
Memory
Memory Disorders - diagnostic imaging
Memory Disorders - etiology
Memory Disorders - physiopathology
Memory, Short-Term - physiology
multidisciplinary
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - physiopathology
Multiple Sclerosis - psychology
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging
Multiple Sclerosis, Relapsing-Remitting - etiology
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Neural networks
Parietal Lobe - diagnostic imaging
Parietal Lobe - physiopathology
Reaction Time
Science
Science (multidisciplinary)
Short term memory
Temporal Lobe - diagnostic imaging
Temporal Lobe - physiopathology
Therapeutic applications
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-020-66279-0

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Abstract Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
AbstractList Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
Abstract Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
ArticleNumber 9310
Author Ciampi, Ethel
Zamorano, Francisco
Aboitiz, Francisco
Cárcamo, Claudia
Henríquez-Ch, Rodrigo
Vásquez, Macarena
Figueroa-Vargas, Alejandra
Billeke, Pablo
Uribe-San-Martin, Reinaldo
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SSID ssj0000529419
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Snippet Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological...
Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological...
Abstract Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological...
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StartPage 9310
SubjectTerms 631/378/2649
692/617/375/1411/1666
Adult
Case-Control Studies
Cognitive ability
EEG
Electroencephalography
Female
Frontal Lobe - diagnostic imaging
Frontal Lobe - physiopathology
Humanities and Social Sciences
Humans
Image Processing, Computer-Assisted
Male
Memory
Memory Disorders - diagnostic imaging
Memory Disorders - etiology
Memory Disorders - physiopathology
Memory, Short-Term - physiology
multidisciplinary
Multiple sclerosis
Multiple Sclerosis - diagnostic imaging
Multiple Sclerosis - physiopathology
Multiple Sclerosis - psychology
Multiple Sclerosis, Relapsing-Remitting - diagnostic imaging
Multiple Sclerosis, Relapsing-Remitting - etiology
Multiple Sclerosis, Relapsing-Remitting - physiopathology
Neural networks
Parietal Lobe - diagnostic imaging
Parietal Lobe - physiopathology
Reaction Time
Science
Science (multidisciplinary)
Short term memory
Temporal Lobe - diagnostic imaging
Temporal Lobe - physiopathology
Therapeutic applications
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Title Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
URI https://link.springer.com/article/10.1038/s41598-020-66279-0
https://www.ncbi.nlm.nih.gov/pubmed/32518271
https://www.proquest.com/docview/2411085191
https://www.proquest.com/docview/2411548677
https://pubmed.ncbi.nlm.nih.gov/PMC7283327
https://doaj.org/article/c3678b7bd47d4e6e8c052f419ee86bdf
Volume 10
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