Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies

• Published in: Nature communications Vol. 10; no. 1; pp. 3883 - 13
• Main Authors: Adachi, Yu, Tonouchi, Keisuke, Nithichanon, Arnone, Kuraoka, Masayuki, Watanabe, Akiko, Shinnakasu, Ryo, Asanuma, Hideki, Ainai, Akira, Ohmi, Yusuke, Yamamoto, Takuya, Ishii, Ken J., Hasegawa, Hideki, Takeyama, Haruko, Lertmemongkolchai, Ganjana, Kurosaki, Tomohiro, Ato, Manabu, Kelsoe, Garnett, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.08.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 49; 49/1; 631/250/2152/2153/1291; 631/326/590; 631/326/596/2553; 64/60; 692/699/255/1578; Animals; Antibodies; Antibodies, Viral - immunology; Antigens; B-Lymphocytes - immunology; Cross Reactions; Epitope Mapping; Epitopes - immunology; Germinal Center - cytology; Germinal Center - immunology; Hemagglutinin Glycoproteins, Influenza Virus - immunology; Hemagglutinins; Humanities and Social Sciences; Humans; Immunization; Immunogenicity; Immunoglobulins; Influenza; Influenza A virus - immunology; Lymphocytes B; Mapping; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; multidisciplinary; Neutralization; Occlusion; Replication; Science; Science (multidisciplinary); Virus Replication; Viruses

Germinal center (GC) B cells at viral replication sites acquire specificity to poorly immunogenic but conserved influenza hemagglutinin (HA) epitopes. Here, high-throughput epitope mapping of local GC B cells is used to identify conserved HA epitope selecting cross-reactive antibodies that mediate h...