Cytokine response in cerebrospinal fluid of meningitis patients and outcome associated with pneumococcal serotype

• Published in: Scientific reports Vol. 11; no. 1; p. 19920
• Main Authors: Müller, Annelies, Schramm, Diana B., Kleynhans, Jackie, de Gouveia, Linda, Meiring, Susan, Ramette, Alban, von Gottberg, Anne, Hathaway, Lucy Jane
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.10.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326; 631/378; 692/308; 692/699; Adolescent; Adult; Aged; Bayesian analysis; Biomarkers; Capsular polysaccharides; Cerebrospinal fluid; Chemokines; Child; Child, Preschool; Cytokines; Cytokines - cerebrospinal fluid; Female; Growth factors; HIV; Human immunodeficiency virus; Humanities and Social Sciences; Humans; Infant; Infant, Newborn; Inflammation; Inflammation Mediators - cerebrospinal fluid; Interleukin 6; Interleukin 8; Male; Meningitis; Meningitis, Pneumococcal - cerebrospinal fluid; Meningitis, Pneumococcal - epidemiology; Meningitis, Pneumococcal - microbiology; Meningitis, Pneumococcal - mortality; Middle Aged; Mortality; multidisciplinary; Patients; Prognosis; Public Health Surveillance; Science; Science (multidisciplinary); Serogroup; Serotypes; South Africa - epidemiology; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pneumoniae - classification; Tumor necrosis factor-α; Young Adult; South Africa

Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the meningeal inflammatory response, we measured 41 cytokines/chemoki...