Cytokine response in cerebrospinal fluid of meningitis patients and outcome associated with pneumococcal serotype

Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the meningeal inflammatory response, we measured 41 cytokines/chemoki...

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Published inScientific reports Vol. 11; no. 1; p. 19920
Main Authors Müller, Annelies, Schramm, Diana B., Kleynhans, Jackie, de Gouveia, Linda, Meiring, Susan, Ramette, Alban, von Gottberg, Anne, Hathaway, Lucy Jane
Format Journal Article
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Published London Nature Publishing Group UK 07.10.2021
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Abstract Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the meningeal inflammatory response, we measured 41 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) samples from 57 South African meningitis patients (collected in the period 2018–2019), with confirmed S. pneumoniae serotypes, using a multiplexed bead-based immunoassay. Based on multivariable Bayesian regression, using serotype 10A as a reference and after adjusting for HIV and age, we found IL-6 concentrations significantly lower in patients infected with serotypes 6D (undetectable) and 23A (1601 pg/ml), IL-8 concentrations significantly higher in those infected with 22A (40,459 pg/ml), 7F (32,400 pg/ml) and 15B/C (6845 pg/ml), and TNFα concentration significantly higher in those infected with serotype 18A (33,097 pg/ml). Although a relatively small number of clinical samples were available for this study and 28% of samples could not be assigned to a definitive serotype, our data suggests 15B/C worthy of monitoring during surveillance as it is associated with in-hospital case fatality and not included in the 13-valent polysaccharide conjugate vaccine, PCV13. Our data provides average CSF concentrations of a range of cytokines and growth factors for 18 different serotypes (14, 19F, 3, 6A, 7F, 19A, 8, 9N, 10A, 12F, 15B/C, 22F, 16F, 23A, 31, 18A, 6D, 22A) to serve as a basis for future studies investigating host–pathogen interaction during pneumococcal meningitis. We note that differences in induction of IL-8 between serotypes may be particularly worthy of future study.
AbstractList Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the meningeal inflammatory response, we measured 41 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) samples from 57 South African meningitis patients (collected in the period 2018–2019), with confirmed S. pneumoniae serotypes, using a multiplexed bead-based immunoassay. Based on multivariable Bayesian regression, using serotype 10A as a reference and after adjusting for HIV and age, we found IL-6 concentrations significantly lower in patients infected with serotypes 6D (undetectable) and 23A (1601 pg/ml), IL-8 concentrations significantly higher in those infected with 22A (40,459 pg/ml), 7F (32,400 pg/ml) and 15B/C (6845 pg/ml), and TNFα concentration significantly higher in those infected with serotype 18A (33,097 pg/ml). Although a relatively small number of clinical samples were available for this study and 28% of samples could not be assigned to a definitive serotype, our data suggests 15B/C worthy of monitoring during surveillance as it is associated with in-hospital case fatality and not included in the 13-valent polysaccharide conjugate vaccine, PCV13. Our data provides average CSF concentrations of a range of cytokines and growth factors for 18 different serotypes (14, 19F, 3, 6A, 7F, 19A, 8, 9N, 10A, 12F, 15B/C, 22F, 16F, 23A, 31, 18A, 6D, 22A) to serve as a basis for future studies investigating host–pathogen interaction during pneumococcal meningitis. We note that differences in induction of IL-8 between serotypes may be particularly worthy of future study.
Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the meningeal inflammatory response, we measured 41 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) samples from 57 South African meningitis patients (collected in the period 2018-2019), with confirmed S. pneumoniae serotypes, using a multiplexed bead-based immunoassay. Based on multivariable Bayesian regression, using serotype 10A as a reference and after adjusting for HIV and age, we found IL-6 concentrations significantly lower in patients infected with serotypes 6D (undetectable) and 23A (1601 pg/ml), IL-8 concentrations significantly higher in those infected with 22A (40,459 pg/ml), 7F (32,400 pg/ml) and 15B/C (6845 pg/ml), and TNFα concentration significantly higher in those infected with serotype 18A (33,097 pg/ml). Although a relatively small number of clinical samples were available for this study and 28% of samples could not be assigned to a definitive serotype, our data suggests 15B/C worthy of monitoring during surveillance as it is associated with in-hospital case fatality and not included in the 13-valent polysaccharide conjugate vaccine, PCV13. Our data provides average CSF concentrations of a range of cytokines and growth factors for 18 different serotypes (14, 19F, 3, 6A, 7F, 19A, 8, 9N, 10A, 12F, 15B/C, 22F, 16F, 23A, 31, 18A, 6D, 22A) to serve as a basis for future studies investigating host-pathogen interaction during pneumococcal meningitis. We note that differences in induction of IL-8 between serotypes may be particularly worthy of future study.
Abstract Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the meningeal inflammatory response, we measured 41 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) samples from 57 South African meningitis patients (collected in the period 2018–2019), with confirmed S. pneumoniae serotypes, using a multiplexed bead-based immunoassay. Based on multivariable Bayesian regression, using serotype 10A as a reference and after adjusting for HIV and age, we found IL-6 concentrations significantly lower in patients infected with serotypes 6D (undetectable) and 23A (1601 pg/ml), IL-8 concentrations significantly higher in those infected with 22A (40,459 pg/ml), 7F (32,400 pg/ml) and 15B/C (6845 pg/ml), and TNFα concentration significantly higher in those infected with serotype 18A (33,097 pg/ml). Although a relatively small number of clinical samples were available for this study and 28% of samples could not be assigned to a definitive serotype, our data suggests 15B/C worthy of monitoring during surveillance as it is associated with in-hospital case fatality and not included in the 13-valent polysaccharide conjugate vaccine, PCV13. Our data provides average CSF concentrations of a range of cytokines and growth factors for 18 different serotypes (14, 19F, 3, 6A, 7F, 19A, 8, 9N, 10A, 12F, 15B/C, 22F, 16F, 23A, 31, 18A, 6D, 22A) to serve as a basis for future studies investigating host–pathogen interaction during pneumococcal meningitis. We note that differences in induction of IL-8 between serotypes may be particularly worthy of future study.
Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the mechanism is largely unknown. Due to evidence of elevated cytokines levels in the meningeal inflammatory response, we measured 41 cytokines/chemokines and growth factors in cerebrospinal fluid (CSF) samples from 57 South African meningitis patients (collected in the period 2018–2019), with confirmed S. pneumoniae serotypes, using a multiplexed bead-based immunoassay. Based on multivariable Bayesian regression, using serotype 10A as a reference and after adjusting for HIV and age, we found IL-6 concentrations significantly lower in patients infected with serotypes 6D (undetectable) and 23A (1601 pg/ml), IL-8 concentrations significantly higher in those infected with 22A (40,459 pg/ml), 7F (32,400 pg/ml) and 15B/C (6845 pg/ml), and TNFα concentration significantly higher in those infected with serotype 18A (33,097 pg/ml). Although a relatively small number of clinical samples were available for this study and 28% of samples could not be assigned to a definitive serotype, our data suggests 15B/C worthy of monitoring during surveillance as it is associated with in-hospital case fatality and not included in the 13-valent polysaccharide conjugate vaccine, PCV13. Our data provides average CSF concentrations of a range of cytokines and growth factors for 18 different serotypes (14, 19F, 3, 6A, 7F, 19A, 8, 9N, 10A, 12F, 15B/C, 22F, 16F, 23A, 31, 18A, 6D, 22A) to serve as a basis for future studies investigating host–pathogen interaction during pneumococcal meningitis. We note that differences in induction of IL-8 between serotypes may be particularly worthy of future study.
ArticleNumber 19920
Author Schramm, Diana B.
Kleynhans, Jackie
Ramette, Alban
Hathaway, Lucy Jane
de Gouveia, Linda
Meiring, Susan
von Gottberg, Anne
Müller, Annelies
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CitedBy_id crossref_primary_10_3389_fcimb_2022_1106063
crossref_primary_10_3892_etm_2023_11903
crossref_primary_10_5937_jomb0_37618
Cites_doi 10.1086/423852
10.1128/mBio.00220-11
10.1371/journal.pone.0149104
10.1046/j.1365-2249.2000.01357.x
10.1016/j.micpath.2018.08.015
10.1371/journal.pone.0009282
10.1007/s10096-014-2062-6
10.1371/journal.ppat.1002574
10.4137/BMI.S35005
10.1371/journal.pmed.1000081
10.1086/423820
10.1371/journal.pone.0039150
10.1086/374624
10.1128/IAI.73.1.431-435.2005
10.1038/s41577-018-0066-7
10.1097/QAI.0b013e3182185276
10.3402/ejpt.v6.25216
10.1086/600045
10.1111/j.1462-5822.2010.01490.x
10.1086/655828
10.1016/j.vaccine.2014.02.096
10.1128/CMR.00024-15
10.1186/1471-2334-4-21
10.1189/jlb.1105626
10.1207/s15327906mbr3904_4
10.1097/INF.0b013e318187e215
10.1186/s12866-020-1700-7
10.1086/341563
10.20982/tqmp.14.2.p099
10.1186/1471-2334-6-78
10.1186/s12866-016-0777-5
10.1056/NEJMoa1401914
10.1098/rsob.150269
10.1128/microbiolspec.GPP3-0019-2018
10.1038/mp.2015.29
10.1080/14760584.2018.1413354
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References Muller (CR15) 2020; 20
Brueggemann (CR11) 2004; 190
Chang (CR21) 2012; 3
van de Schoot (CR26) 2015; 6
von Gottberg (CR4) 2014; 371
Mogensen (CR22) 2006; 80
Hathaway (CR17) 2016; 6
Jwa (CR23) 2018; 124
Geno (CR1) 2015; 28
Hathaway (CR16) 2012; 8
Izurieta (CR3) 2018; 17
Hanage (CR6) 2005; 73
van Hoek (CR12) 2012; 7
Meiring (CR27) 2016; 11
Ruckinger (CR8) 2009; 28
Hornig (CR25) 2016; 21
Paton, Trappetti (CR10) 2019; 7
Ostergaard (CR30) 2006; 6
Banerjee (CR33) 2010; 12
Ostergaard (CR34) 2004; 190
Azzari (CR24) 2010; 5
Harboe (CR7) 2009; 6
Cockeran (CR32) 2002; 186
Jones, Jenkins (CR29) 2018; 18
Ostergaard (CR31) 2000; 122
Weinberger (CR14) 2010; 51
Perdomo-Celis (CR18) 2015; 10
Lee, Song (CR36) 2004; 39
Jansen (CR13) 2009; 49
Fletcher (CR2) 2014; 33
Brueggemann (CR5) 2003; 187
Grabenstein, Musey (CR19) 2014; 32
Martens (CR9) 2004; 4
Baumgartner (CR20) 2016; 16
Muth, Oravecz, Gabry (CR28) 2018; 14
Melchjorsen (CR35) 2011; 57
MA Fletcher (99190_CR2) 2014; 33
W Hanage (99190_CR6) 2005; 73
LJ Hathaway (99190_CR16) 2012; 8
S Meiring (99190_CR27) 2016; 11
C Ostergaard (99190_CR30) 2006; 6
D Baumgartner (99190_CR20) 2016; 16
YC Chang (99190_CR21) 2012; 3
J Melchjorsen (99190_CR35) 2011; 57
TH Mogensen (99190_CR22) 2006; 80
C Ostergaard (99190_CR34) 2004; 190
ZB Harboe (99190_CR7) 2009; 6
C Muth (99190_CR28) 2018; 14
SA Jones (99190_CR29) 2018; 18
DM Weinberger (99190_CR14) 2010; 51
A Muller (99190_CR15) 2020; 20
MY Jwa (99190_CR23) 2018; 124
F Perdomo-Celis (99190_CR18) 2015; 10
S-Y Lee (99190_CR36) 2004; 39
A Banerjee (99190_CR33) 2010; 12
JD Grabenstein (99190_CR19) 2014; 32
R Cockeran (99190_CR32) 2002; 186
A von Gottberg (99190_CR4) 2014; 371
M Hornig (99190_CR25) 2016; 21
P Izurieta (99190_CR3) 2018; 17
A Brueggemann (99190_CR5) 2003; 187
R van de Schoot (99190_CR26) 2015; 6
P Martens (99190_CR9) 2004; 4
AB Brueggemann (99190_CR11) 2004; 190
LJ Hathaway (99190_CR17) 2016; 6
C Azzari (99190_CR24) 2010; 5
JC Paton (99190_CR10) 2019; 7
C Ostergaard (99190_CR31) 2000; 122
S Ruckinger (99190_CR8) 2009; 28
A Jansen (99190_CR13) 2009; 49
AJ van Hoek (99190_CR12) 2012; 7
KA Geno (99190_CR1) 2015; 28
References_xml – volume: 190
  start-page: 1212
  issue: 7
  year: 2004
  end-page: 1220
  ident: CR34
  article-title: Differences in survival, brain damage, and cerebrospinal fluid cytokine kinetics due to meningitis caused by 3 different serotypes: Evaluation in humans and in 2 experimental models
  publication-title: J. Infect. Dis.
  doi: 10.1086/423852
  contributor:
    fullname: Ostergaard
– volume: 3
  start-page: 11
  issue: 1
  year: 2012
  ident: CR21
  article-title: Leukocyte inflammatory responses provoked by pneumococcal sialidase
  publication-title: MBio
  doi: 10.1128/mBio.00220-11
  contributor:
    fullname: Chang
– volume: 11
  start-page: e0149104
  year: 2016
  ident: CR27
  article-title: HIV infection and the epidemiology of invasive pneumococcal disease (IPD) in South African adults and older children prior to the introduction of a pneumococcal conjugate vaccine (PCV)
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0149104
  contributor:
    fullname: Meiring
– volume: 122
  start-page: 207
  issue: 2
  year: 2000
  end-page: 211
  ident: CR31
  article-title: Treatment with a monocolonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally
  publication-title: Clin. Exp. Immunol.
  doi: 10.1046/j.1365-2249.2000.01357.x
  contributor:
    fullname: Ostergaard
– volume: 124
  start-page: 38
  year: 2018
  end-page: 46
  ident: CR23
  article-title: Gamma-irradiation-killed potently induces the expression of IL-6 and IL-8 in human bronchial epithelial cells
  publication-title: Microb. Pathog.
  doi: 10.1016/j.micpath.2018.08.015
  contributor:
    fullname: Jwa
– volume: 5
  start-page: e9282
  issue: 2
  year: 2010
  ident: CR24
  article-title: Realtime PCR is more sensitive than multiplex PCR for diagnosis and serotyping in children with culture negative pneumococcal invasive disease
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0009282
  contributor:
    fullname: Azzari
– volume: 33
  start-page: 879
  issue: 6
  year: 2014
  end-page: 910
  ident: CR2
  article-title: Pneumococcal empyema and complicated pneumonias: Global trends in incidence, prevalence, and serotype epidemiology
  publication-title: Eur. J. Clin. Microbiol. Infect. Dis.
  doi: 10.1007/s10096-014-2062-6
  contributor:
    fullname: Fletcher
– volume: 8
  start-page: e1002574
  issue: 3
  year: 2012
  ident: CR16
  article-title: Capsule type of determines growth phenotype
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1002574
  contributor:
    fullname: Hathaway
– volume: 10
  start-page: 125
  year: 2015
  end-page: 131
  ident: CR18
  article-title: Patterns of local and systemic cytokines in bacterial meningitis and its relation with severity and long-term sequelae
  publication-title: Biomark Insights
  doi: 10.4137/BMI.S35005
  contributor:
    fullname: Perdomo-Celis
– volume: 6
  start-page: e1000081
  issue: 5
  year: 2009
  ident: CR7
  article-title: Pneumococcal serotypes and mortality following invasive pneumococcal disease: A population-based cohort study
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.1000081
  contributor:
    fullname: Harboe
– volume: 190
  start-page: 1203
  issue: 7
  year: 2004
  end-page: 1211
  ident: CR11
  article-title: Temporal and geographic stability of the serogroup-specific invasive disease potential of in children
  publication-title: J. Infect. Dis.
  doi: 10.1086/423820
  contributor:
    fullname: Brueggemann
– volume: 7
  start-page: 39150
  issue: 7
  year: 2012
  ident: CR12
  article-title: Effect of serotype on focus and mortality of invasive pneumococcal disease: Coverage of different vaccines and insight into non-vaccine serotypes
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0039150
  contributor:
    fullname: van Hoek
– volume: 187
  start-page: 1424
  year: 2003
  end-page: 1432
  ident: CR5
  article-title: Clonal relationships between invasive and carriage and serotype- and clone-specific differences in invasive disease potential
  publication-title: J. Infect. Dis.
  doi: 10.1086/374624
  contributor:
    fullname: Brueggemann
– volume: 73
  start-page: 431
  year: 2005
  end-page: 435
  ident: CR6
  article-title: Invasiveness of serotypes and clones of among children in Finland
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.73.1.431-435.2005
  contributor:
    fullname: Hanage
– volume: 18
  start-page: 773
  issue: 12
  year: 2018
  end-page: 789
  ident: CR29
  article-title: Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-018-0066-7
  contributor:
    fullname: Jenkins
– volume: 57
  start-page: 265
  issue: 4
  year: 2011
  end-page: 275
  ident: CR35
  article-title: Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12/IL-10 balance in human primary cells
  publication-title: J. Acquir. Immune Defic. Syndr.
  doi: 10.1097/QAI.0b013e3182185276
  contributor:
    fullname: Melchjorsen
– volume: 6
  start-page: 25216
  year: 2015
  end-page: 25216
  ident: CR26
  article-title: Analyzing small data sets using Bayesian estimation: The case of posttraumatic stress symptoms following mechanical ventilation in burn survivors
  publication-title: Eur. J. Psychotraumatol.
  doi: 10.3402/ejpt.v6.25216
  contributor:
    fullname: van de Schoot
– volume: 49
  start-page: e23
  year: 2009
  end-page: 29
  ident: CR13
  article-title: Invasive pneumococcal disease among adults: Associations among serotypes, disease characteristics and outcome
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/600045
  contributor:
    fullname: Jansen
– volume: 12
  start-page: 1576
  issue: 11
  year: 2010
  end-page: 1588
  ident: CR33
  article-title: Activation of brain endothelium by pneumococcal neuraminidase NanA promotes bacterial internalization
  publication-title: Cell Microbiol.
  doi: 10.1111/j.1462-5822.2010.01490.x
  contributor:
    fullname: Banerjee
– volume: 51
  start-page: 692
  issue: 6
  year: 2010
  end-page: 699
  ident: CR14
  article-title: Association of serotype with risk of death due to pneumococcal pneumonia: A meta-analysis
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/655828
  contributor:
    fullname: Weinberger
– volume: 32
  start-page: 2399
  issue: 21
  year: 2014
  end-page: 2405
  ident: CR19
  article-title: Differences in serious clinical outcomes of infection caused by specific pneumococcal serotypes among adults
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2014.02.096
  contributor:
    fullname: Musey
– volume: 28
  start-page: 871
  issue: 3
  year: 2015
  end-page: 899
  ident: CR1
  article-title: Pneumococcal capsules and their types: Past, present, and future
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00024-15
  contributor:
    fullname: Geno
– volume: 4
  start-page: 21
  year: 2004
  ident: CR9
  article-title: Serotype-specific mortality from invasive disease revisited
  publication-title: BMC Infect. Dis.
  doi: 10.1186/1471-2334-4-21
  contributor:
    fullname: Martens
– volume: 80
  start-page: 267
  issue: 2
  year: 2006
  end-page: 277
  ident: CR22
  article-title: Live , , and activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.1105626
  contributor:
    fullname: Mogensen
– volume: 39
  start-page: 653
  issue: 4
  year: 2004
  end-page: 686
  ident: CR36
  article-title: Evaluation of the Bayesian and maximum likelihood approaches in analyzing structural equation models with small sample sizes
  publication-title: Multivar. Behav. Res.
  doi: 10.1207/s15327906mbr3904_4
  contributor:
    fullname: Song
– volume: 28
  start-page: 118
  issue: 2
  year: 2009
  end-page: 122
  ident: CR8
  article-title: Association of serotype of with risk of severe and fatal outcome
  publication-title: Pediatr. Infect. Dis. J.
  doi: 10.1097/INF.0b013e318187e215
  contributor:
    fullname: Ruckinger
– volume: 20
  start-page: 16
  issue: 1
  year: 2020
  ident: CR15
  article-title: Pneumococcal serotype determines growth and capsule size in human cerebrospinal fluid
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-020-1700-7
  contributor:
    fullname: Muller
– volume: 186
  start-page: 562
  issue: 4
  year: 2002
  end-page: 565
  ident: CR32
  article-title: Pneumolysin activates the synthesis and release of interleukin-8 by human neutrophils in vitro
  publication-title: J. Infect. Dis.
  doi: 10.1086/341563
  contributor:
    fullname: Cockeran
– volume: 14
  start-page: 99
  issue: 2
  year: 2018
  end-page: 119
  ident: CR28
  article-title: User-friendly Bayesian regression modeling: A tutorial with rstanarm and shinystan
  publication-title: Quant. Methods Psychol.
  doi: 10.20982/tqmp.14.2.p099
  contributor:
    fullname: Gabry
– volume: 6
  start-page: 78
  year: 2006
  ident: CR30
  article-title: Influence of the blood bacterial load on the meningeal inflammatory response in meningitis
  publication-title: BMC Infect. Dis.
  doi: 10.1186/1471-2334-6-78
  contributor:
    fullname: Ostergaard
– volume: 16
  start-page: 154
  issue: 1
  year: 2016
  ident: CR20
  article-title: Clinical isolates induce differing CXCL8 responses from human nasopharyngeal epithelial cells which are reduced by liposomes
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-016-0777-5
  contributor:
    fullname: Baumgartner
– volume: 371
  start-page: 1889
  issue: 20
  year: 2014
  end-page: 1899
  ident: CR4
  article-title: Effects of vaccination on invasive pneumococcal disease in South Africa
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1401914
  contributor:
    fullname: von Gottberg
– volume: 6
  start-page: 150269
  issue: 3
  year: 2016
  ident: CR17
  article-title: capsule determines disease severity in experimental pneumococcal meningitis
  publication-title: Open Biol.
  doi: 10.1098/rsob.150269
  contributor:
    fullname: Hathaway
– volume: 7
  start-page: 2018
  issue: 2
  year: 2019
  ident: CR10
  article-title: capsular polysaccharide
  publication-title: Microbiol. Spectr.
  doi: 10.1128/microbiolspec.GPP3-0019-2018
  contributor:
    fullname: Trappetti
– volume: 21
  start-page: 261
  issue: 2
  year: 2016
  end-page: 269
  ident: CR25
  article-title: Cytokine network analysis of cerebrospinal fluid in myalgic encephalomyelitis/chronic fatigue syndrome
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2015.29
  contributor:
    fullname: Hornig
– volume: 17
  start-page: 479
  issue: 6
  year: 2018
  end-page: 493
  ident: CR3
  article-title: Public health impact of pneumococcal conjugate vaccine infant immunization programs: Assessment of invasive pneumococcal disease burden and serotype distribution
  publication-title: Expert Rev. Vaccines
  doi: 10.1080/14760584.2018.1413354
  contributor:
    fullname: Izurieta
– volume: 5
  start-page: e9282
  issue: 2
  year: 2010
  ident: 99190_CR24
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0009282
  contributor:
    fullname: C Azzari
– volume: 6
  start-page: e1000081
  issue: 5
  year: 2009
  ident: 99190_CR7
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.1000081
  contributor:
    fullname: ZB Harboe
– volume: 39
  start-page: 653
  issue: 4
  year: 2004
  ident: 99190_CR36
  publication-title: Multivar. Behav. Res.
  doi: 10.1207/s15327906mbr3904_4
  contributor:
    fullname: S-Y Lee
– volume: 6
  start-page: 78
  year: 2006
  ident: 99190_CR30
  publication-title: BMC Infect. Dis.
  doi: 10.1186/1471-2334-6-78
  contributor:
    fullname: C Ostergaard
– volume: 190
  start-page: 1203
  issue: 7
  year: 2004
  ident: 99190_CR11
  publication-title: J. Infect. Dis.
  doi: 10.1086/423820
  contributor:
    fullname: AB Brueggemann
– volume: 21
  start-page: 261
  issue: 2
  year: 2016
  ident: 99190_CR25
  publication-title: Mol. Psychiatry
  doi: 10.1038/mp.2015.29
  contributor:
    fullname: M Hornig
– volume: 187
  start-page: 1424
  year: 2003
  ident: 99190_CR5
  publication-title: J. Infect. Dis.
  doi: 10.1086/374624
  contributor:
    fullname: A Brueggemann
– volume: 51
  start-page: 692
  issue: 6
  year: 2010
  ident: 99190_CR14
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/655828
  contributor:
    fullname: DM Weinberger
– volume: 18
  start-page: 773
  issue: 12
  year: 2018
  ident: 99190_CR29
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/s41577-018-0066-7
  contributor:
    fullname: SA Jones
– volume: 6
  start-page: 25216
  year: 2015
  ident: 99190_CR26
  publication-title: Eur. J. Psychotraumatol.
  doi: 10.3402/ejpt.v6.25216
  contributor:
    fullname: R van de Schoot
– volume: 12
  start-page: 1576
  issue: 11
  year: 2010
  ident: 99190_CR33
  publication-title: Cell Microbiol.
  doi: 10.1111/j.1462-5822.2010.01490.x
  contributor:
    fullname: A Banerjee
– volume: 7
  start-page: 2018
  issue: 2
  year: 2019
  ident: 99190_CR10
  publication-title: Microbiol. Spectr.
  doi: 10.1128/microbiolspec.GPP3-0019-2018
  contributor:
    fullname: JC Paton
– volume: 28
  start-page: 118
  issue: 2
  year: 2009
  ident: 99190_CR8
  publication-title: Pediatr. Infect. Dis. J.
  doi: 10.1097/INF.0b013e318187e215
  contributor:
    fullname: S Ruckinger
– volume: 32
  start-page: 2399
  issue: 21
  year: 2014
  ident: 99190_CR19
  publication-title: Vaccine
  doi: 10.1016/j.vaccine.2014.02.096
  contributor:
    fullname: JD Grabenstein
– volume: 73
  start-page: 431
  year: 2005
  ident: 99190_CR6
  publication-title: Infect. Immun.
  doi: 10.1128/IAI.73.1.431-435.2005
  contributor:
    fullname: W Hanage
– volume: 20
  start-page: 16
  issue: 1
  year: 2020
  ident: 99190_CR15
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-020-1700-7
  contributor:
    fullname: A Muller
– volume: 8
  start-page: e1002574
  issue: 3
  year: 2012
  ident: 99190_CR16
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1002574
  contributor:
    fullname: LJ Hathaway
– volume: 80
  start-page: 267
  issue: 2
  year: 2006
  ident: 99190_CR22
  publication-title: J. Leukoc. Biol.
  doi: 10.1189/jlb.1105626
  contributor:
    fullname: TH Mogensen
– volume: 122
  start-page: 207
  issue: 2
  year: 2000
  ident: 99190_CR31
  publication-title: Clin. Exp. Immunol.
  doi: 10.1046/j.1365-2249.2000.01357.x
  contributor:
    fullname: C Ostergaard
– volume: 16
  start-page: 154
  issue: 1
  year: 2016
  ident: 99190_CR20
  publication-title: BMC Microbiol.
  doi: 10.1186/s12866-016-0777-5
  contributor:
    fullname: D Baumgartner
– volume: 11
  start-page: e0149104
  year: 2016
  ident: 99190_CR27
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0149104
  contributor:
    fullname: S Meiring
– volume: 14
  start-page: 99
  issue: 2
  year: 2018
  ident: 99190_CR28
  publication-title: Quant. Methods Psychol.
  doi: 10.20982/tqmp.14.2.p099
  contributor:
    fullname: C Muth
– volume: 17
  start-page: 479
  issue: 6
  year: 2018
  ident: 99190_CR3
  publication-title: Expert Rev. Vaccines
  doi: 10.1080/14760584.2018.1413354
  contributor:
    fullname: P Izurieta
– volume: 186
  start-page: 562
  issue: 4
  year: 2002
  ident: 99190_CR32
  publication-title: J. Infect. Dis.
  doi: 10.1086/341563
  contributor:
    fullname: R Cockeran
– volume: 28
  start-page: 871
  issue: 3
  year: 2015
  ident: 99190_CR1
  publication-title: Clin. Microbiol. Rev.
  doi: 10.1128/CMR.00024-15
  contributor:
    fullname: KA Geno
– volume: 124
  start-page: 38
  year: 2018
  ident: 99190_CR23
  publication-title: Microb. Pathog.
  doi: 10.1016/j.micpath.2018.08.015
  contributor:
    fullname: MY Jwa
– volume: 3
  start-page: 11
  issue: 1
  year: 2012
  ident: 99190_CR21
  publication-title: MBio
  doi: 10.1128/mBio.00220-11
  contributor:
    fullname: YC Chang
– volume: 57
  start-page: 265
  issue: 4
  year: 2011
  ident: 99190_CR35
  publication-title: J. Acquir. Immune Defic. Syndr.
  doi: 10.1097/QAI.0b013e3182185276
  contributor:
    fullname: J Melchjorsen
– volume: 371
  start-page: 1889
  issue: 20
  year: 2014
  ident: 99190_CR4
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1401914
  contributor:
    fullname: A von Gottberg
– volume: 33
  start-page: 879
  issue: 6
  year: 2014
  ident: 99190_CR2
  publication-title: Eur. J. Clin. Microbiol. Infect. Dis.
  doi: 10.1007/s10096-014-2062-6
  contributor:
    fullname: MA Fletcher
– volume: 49
  start-page: e23
  year: 2009
  ident: 99190_CR13
  publication-title: Clin. Infect. Dis.
  doi: 10.1086/600045
  contributor:
    fullname: A Jansen
– volume: 7
  start-page: 39150
  issue: 7
  year: 2012
  ident: 99190_CR12
  publication-title: PLoS ONE
  doi: 10.1371/journal.pone.0039150
  contributor:
    fullname: AJ van Hoek
– volume: 10
  start-page: 125
  year: 2015
  ident: 99190_CR18
  publication-title: Biomark Insights
  doi: 10.4137/BMI.S35005
  contributor:
    fullname: F Perdomo-Celis
– volume: 190
  start-page: 1212
  issue: 7
  year: 2004
  ident: 99190_CR34
  publication-title: J. Infect. Dis.
  doi: 10.1086/423852
  contributor:
    fullname: C Ostergaard
– volume: 4
  start-page: 21
  year: 2004
  ident: 99190_CR9
  publication-title: BMC Infect. Dis.
  doi: 10.1186/1471-2334-4-21
  contributor:
    fullname: P Martens
– volume: 6
  start-page: 150269
  issue: 3
  year: 2016
  ident: 99190_CR17
  publication-title: Open Biol.
  doi: 10.1098/rsob.150269
  contributor:
    fullname: LJ Hathaway
SSID ssj0000529419
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Snippet Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the...
Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but the...
Abstract Streptococcus pneumoniae causes life-threatening meningitis. Its capsular polysaccharide determines the serotype and influences disease severity but...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Publisher
StartPage 19920
SubjectTerms 631/326
631/378
692/308
692/699
Adolescent
Adult
Aged
Bayesian analysis
Biomarkers
Capsular polysaccharides
Cerebrospinal fluid
Chemokines
Child
Child, Preschool
Cytokines
Cytokines - cerebrospinal fluid
Female
Growth factors
HIV
Human immunodeficiency virus
Humanities and Social Sciences
Humans
Infant
Infant, Newborn
Inflammation
Inflammation Mediators - cerebrospinal fluid
Interleukin 6
Interleukin 8
Male
Meningitis
Meningitis, Pneumococcal - cerebrospinal fluid
Meningitis, Pneumococcal - epidemiology
Meningitis, Pneumococcal - microbiology
Meningitis, Pneumococcal - mortality
Middle Aged
Mortality
multidisciplinary
Patients
Prognosis
Public Health Surveillance
Science
Science (multidisciplinary)
Serogroup
Serotypes
South Africa - epidemiology
Streptococcus infections
Streptococcus pneumoniae
Streptococcus pneumoniae - classification
Tumor necrosis factor-α
Young Adult
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Title Cytokine response in cerebrospinal fluid of meningitis patients and outcome associated with pneumococcal serotype
URI https://link.springer.com/article/10.1038/s41598-021-99190-3
https://www.ncbi.nlm.nih.gov/pubmed/34620928
https://www.proquest.com/docview/2579865850
https://search.proquest.com/docview/2580700468
https://pubmed.ncbi.nlm.nih.gov/PMC8497479
https://doaj.org/article/35c3be3933c84aeabf61e94a6c87c84b
Volume 11
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