A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy

• Published in: Nature communications Vol. 12; no. 1; pp. 1087 - 12
• Main Authors: Li, Junrong, Wuethrich, Alain, Sina, Abu A. I., Cheng, Han-Hao, Wang, Yuling, Behren, Andreas, Mainwaring, Paul N., Trau, Matt
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.02.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 140/133; 631/61/350; 639/301/357/537; 639/301/930/527/1821; 692/699/67/1059/2325; 9/10; Biomarkers; Cancer; Chemokine CX3CL1 - immunology; Chemokine CX3CL1 - metabolism; Cohort Studies; Cytokines; Cytokines - immunology; Cytokines - metabolism; Granulocyte Colony-Stimulating Factor - immunology; Granulocyte Colony-Stimulating Factor - metabolism; Granulocyte-Macrophage Colony-Stimulating Factor - immunology; Granulocyte-Macrophage Colony-Stimulating Factor - metabolism; Health services; Humanities and Social Sciences; Humans; Immune checkpoint inhibitors; Immune Checkpoint Inhibitors - adverse effects; Immune Checkpoint Inhibitors - immunology; Immune Checkpoint Inhibitors - therapeutic use; Immunotherapy; Immunotherapy - methods; Inflammation; Inhibitors; Ipilimumab - adverse effects; Ipilimumab - immunology; Ipilimumab - therapeutic use; Melanoma; Melanoma - immunology; Melanoma - metabolism; Melanoma - therapy; Microscopy, Confocal - methods; Monitoring; Monitoring, Immunologic - methods; multidisciplinary; Patients; Pilot Projects; Reproducibility of Results; Science; Science (multidisciplinary); Spectrum Analysis, Raman - methods; Telemedicine; Toxicity

The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry significant and sometimes life-threatening toxicities. Prompt prediction and monitoring of immune toxicities have the potential to maximise the b...