A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy

The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry significant and sometimes life-threatening toxicities. Prompt prediction and monitoring of immune toxicities have the potential to maximise the b...

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Published inNature communications Vol. 12; no. 1; pp. 1087 - 12
Main Authors Li, Junrong, Wuethrich, Alain, Sina, Abu A. I., Cheng, Han-Hao, Wang, Yuling, Behren, Andreas, Mainwaring, Paul N., Trau, Matt
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 17.02.2021
Nature Publishing Group
Nature Portfolio
Subjects
140/133
631/61/350
639/301/357/537
639/301/930/527/1821
692/699/67/1059/2325
9/10
Biomarkers
Cancer
Chemokine CX3CL1 - immunology
Chemokine CX3CL1 - metabolism
Cohort Studies
Cytokines
Cytokines - immunology
Cytokines - metabolism
Granulocyte Colony-Stimulating Factor - immunology
Granulocyte Colony-Stimulating Factor - metabolism
Granulocyte-Macrophage Colony-Stimulating Factor - immunology
Granulocyte-Macrophage Colony-Stimulating Factor - metabolism
Health services
Humanities and Social Sciences
Humans
Immune checkpoint inhibitors
Immune Checkpoint Inhibitors - adverse effects
Immune Checkpoint Inhibitors - immunology
Immune Checkpoint Inhibitors - therapeutic use
Immunotherapy
Immunotherapy - methods
Inflammation
Inhibitors
Ipilimumab - adverse effects
Ipilimumab - immunology
Ipilimumab - therapeutic use
Melanoma
Melanoma - immunology
Melanoma - metabolism
Melanoma - therapy
Microscopy, Confocal - methods
Monitoring
Monitoring, Immunologic - methods
multidisciplinary
Patients
Pilot Projects
Reproducibility of Results
Science
Science (multidisciplinary)
Spectrum Analysis, Raman - methods
Telemedicine
Toxicity
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Abstract The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry significant and sometimes life-threatening toxicities. Prompt prediction and monitoring of immune toxicities have the potential to maximise the benefits of immune checkpoint therapy. Herein, we develop a digital nanopillar SERS platform that achieves real-time single cytokine counting and enables dynamic tracking of immune toxicities in cancer patients receiving immune checkpoint inhibitor treatment - broader applications are anticipated in other disease indications. By analysing four prospective cytokine biomarkers that initiate inflammatory responses, the digital nanopillar SERS assay achieves both highly specific and highly sensitive cytokine detection down to attomolar level. Significantly, we report the capability of the assay to longitudinally monitor 10 melanoma patients during immune inhibitor blockade treatment. Here, we show that elevated cytokine concentrations predict for higher risk of developing severe immune toxicities in our pilot cohort of patients. There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher risk.
AbstractList The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry significant and sometimes life-threatening toxicities. Prompt prediction and monitoring of immune toxicities have the potential to maximise the benefits of immune checkpoint therapy. Herein, we develop a digital nanopillar SERS platform that achieves real-time single cytokine counting and enables dynamic tracking of immune toxicities in cancer patients receiving immune checkpoint inhibitor treatment - broader applications are anticipated in other disease indications. By analysing four prospective cytokine biomarkers that initiate inflammatory responses, the digital nanopillar SERS assay achieves both highly specific and highly sensitive cytokine detection down to attomolar level. Significantly, we report the capability of the assay to longitudinally monitor 10 melanoma patients during immune inhibitor blockade treatment. Here, we show that elevated cytokine concentrations predict for higher risk of developing severe immune toxicities in our pilot cohort of patients.
The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry significant and sometimes life-threatening toxicities. Prompt prediction and monitoring of immune toxicities have the potential to maximise the benefits of immune checkpoint therapy. Herein, we develop a digital nanopillar SERS platform that achieves real-time single cytokine counting and enables dynamic tracking of immune toxicities in cancer patients receiving immune checkpoint inhibitor treatment - broader applications are anticipated in other disease indications. By analysing four prospective cytokine biomarkers that initiate inflammatory responses, the digital nanopillar SERS assay achieves both highly specific and highly sensitive cytokine detection down to attomolar level. Significantly, we report the capability of the assay to longitudinally monitor 10 melanoma patients during immune inhibitor blockade treatment. Here, we show that elevated cytokine concentrations predict for higher risk of developing severe immune toxicities in our pilot cohort of patients. There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher risk.
The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry significant and sometimes life-threatening toxicities. Prompt prediction and monitoring of immune toxicities have the potential to maximise the benefits of immune checkpoint therapy. Herein, we develop a digital nanopillar SERS platform that achieves real-time single cytokine counting and enables dynamic tracking of immune toxicities in cancer patients receiving immune checkpoint inhibitor treatment - broader applications are anticipated in other disease indications. By analysing four prospective cytokine biomarkers that initiate inflammatory responses, the digital nanopillar SERS assay achieves both highly specific and highly sensitive cytokine detection down to attomolar level. Significantly, we report the capability of the assay to longitudinally monitor 10 melanoma patients during immune inhibitor blockade treatment. Here, we show that elevated cytokine concentrations predict for higher risk of developing severe immune toxicities in our pilot cohort of patients.There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher risk.
There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for multiplexed single cytokine counting to track immune-toxicities and demonstrate the ability to use pre-screening to identify patients at higher risk.
ArticleNumber 1087
Author Wuethrich, Alain
Cheng, Han-Hao
Mainwaring, Paul N.
Trau, Matt
Wang, Yuling
Behren, Andreas
Sina, Abu A. I.
Li, Junrong
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PublicationDecade 2020
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PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2021
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
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Snippet The introduction of immune checkpoint inhibitors has demonstrated significant improvements in survival for subsets of cancer patients. However, they carry...
There is a clinical need to monitor immune-related toxicities of immune checkpoint blockade therapy. Here, the authors develop a digital SERS platform for...
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SubjectTerms 140/133
631/61/350
639/301/357/537
639/301/930/527/1821
692/699/67/1059/2325
9/10
Biomarkers
Cancer
Chemokine CX3CL1 - immunology
Chemokine CX3CL1 - metabolism
Cohort Studies
Cytokines
Cytokines - immunology
Cytokines - metabolism
Granulocyte Colony-Stimulating Factor - immunology
Granulocyte Colony-Stimulating Factor - metabolism
Granulocyte-Macrophage Colony-Stimulating Factor - immunology
Granulocyte-Macrophage Colony-Stimulating Factor - metabolism
Health services
Humanities and Social Sciences
Humans
Immune checkpoint inhibitors
Immune Checkpoint Inhibitors - adverse effects
Immune Checkpoint Inhibitors - immunology
Immune Checkpoint Inhibitors - therapeutic use
Immunotherapy
Immunotherapy - methods
Inflammation
Inhibitors
Ipilimumab - adverse effects
Ipilimumab - immunology
Ipilimumab - therapeutic use
Melanoma
Melanoma - immunology
Melanoma - metabolism
Melanoma - therapy
Microscopy, Confocal - methods
Monitoring
Monitoring, Immunologic - methods
multidisciplinary
Patients
Pilot Projects
Reproducibility of Results
Science
Science (multidisciplinary)
Spectrum Analysis, Raman - methods
Telemedicine
Toxicity
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Title A digital single-molecule nanopillar SERS platform for predicting and monitoring immune toxicities in immunotherapy
URI https://link.springer.com/article/10.1038/s41467-021-21431-w
https://www.ncbi.nlm.nih.gov/pubmed/33597530
https://www.proquest.com/docview/2490397846
https://pubmed.ncbi.nlm.nih.gov/PMC7889912
https://doaj.org/article/ad3a6c015bda45c3bc4d1c2fcc075fea
Volume 12
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