Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles

• Published in: Nature communications Vol. 11; no. 1; p. 5637
• Main Authors: Hilligan, Kerry L., Tang, Shiau-Choot, Hyde, Evelyn J., Roussel, Elsa, Mayer, Johannes U., Yang, Jianping, Wakelin, Kirsty A., Schmidt, Alfonso J., Connor, Lisa M., Sher, Alan, MacDonald, Andrew S., Ronchese, Franca
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.11.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/21; 13/31; 631/250/1619/554/1898; 631/250/21/1293; 631/250/2499; 631/250/2504/133; 64/110; 64/60; Animals; Antigen-presenting cells; Antigen-Presenting Cells - immunology; Antigens; CD4 antigen; Cell Differentiation; Cell migration; Chemokines; Cytokines; Dendritic cells; Dendritic Cells - immunology; Dendritic structure; Depletion; Differentiation (biology); Female; Fungi; Helper cells; Humanities and Social Sciences; Inoculation; Interferon regulatory factor 4; Interferon Regulatory Factors - genetics; Interferon Regulatory Factors - immunology; Interferon-gamma - genetics; Interferon-gamma - immunology; Interleukin 12; Interleukin 4; Interleukin-17 - genetics; Interleukin-17 - immunology; Interleukin-4 - genetics; Interleukin-4 - immunology; Lymph nodes; Lymphocyte Activation; Lymphocytes T; Male; Mice; Mice, Inbred C57BL; Monocytes; Monocytes - cytology; Monocytes - immunology; multidisciplinary; Pathogens; Science; Science (multidisciplinary); Skin; Skin - immunology; T-Lymphocytes, Helper-Inducer - cytology; T-Lymphocytes, Helper-Inducer - immunology; Transcription; γ-Interferon

Antigen (Ag)-presenting cells (APC) instruct CD4+ helper T (Th) cell responses, but it is unclear whether different APC subsets contribute uniquely in determining Th differentiation in pathogen-specific settings. Here, we use skin-relevant, fluorescently-labeled bacterial, helminth or fungal pathoge...