Effects of Age and Sex on the Single-Dose Pharmacokinetics and Pharmacodynamics of Apixaban

• Published in: Clinical pharmacokinetics Vol. 54; no. 6; pp. 651 - 662
• Main Authors: Frost, Charles E., Song, Yan, Shenker, Andrew, Wang, Jessie, Barrett, Yu Chen, Schuster, Alan, Harris, Stuart I., LaCreta, Frank
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2015; Springer Nature B.V
• Subjects: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Area Under Curve; Dose-Response Relationship, Drug; Drug Administration Schedule; Factor Xa Inhibitors - administration & dosage; Factor Xa Inhibitors - blood; Factor Xa Inhibitors - pharmacokinetics; Female; Humans; Internal Medicine; International Normalized Ratio; Male; Medicine; Medicine & Public Health; Original; Original Research Article; Pharmacology/Toxicology; Pharmacotherapy; Pyrazoles - administration & dosage; Pyrazoles - blood; Pyrazoles - pharmacokinetics; Pyridones - administration & dosage; Pyridones - blood; Pyridones - pharmacokinetics; Regression Analysis; Sex Factors; Young Adult; International Normalize Ratio; Maximum Observe Plasma Concentration; Elderly Female; Individual Subject Data; Apixaban

Background and Objectives The effects of age and sex on apixaban pharmacokinetics and pharmacodynamics were studied. Methods This was an open-label, single-dose, 2 × 2 factorial study. Healthy young (aged 18–40 years) and elderly (aged ≥65 years) male and female subjects received a single oral 20 mg...