Dissociation of the respiratory syncytial virus F protein-specific human IgG, IgA and IgM response

• Published in: Scientific reports Vol. 11; no. 1; pp. 3551 - 16
• Main Authors: Borochova, Kristina, Niespodziana, Katarzyna, Focke-Tejkl, Margarete, Hofer, Gerhard, Keller, Walter, Valenta, Rudolf
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 11.02.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250; 631/250/2152; 631/250/2152/2153; 631/250/2152/2153/1291; Antibodies; Antibodies, Neutralizing - genetics; Antibodies, Neutralizing - immunology; Antibodies, Viral - genetics; Antibodies, Viral - immunology; Antibody response; Children; E coli; Epitopes; Epitopes - immunology; F protein; Furin; Fusion protein; Humanities and Social Sciences; Humans; Immune response; Immunoglobulin A; Immunoglobulin A - immunology; Immunoglobulin G; Immunoglobulin G - immunology; Immunoglobulin M; Immunoglobulin M - immunology; Insect cells; Monoclonal antibodies; multidisciplinary; Peptides; Protein structure; Proteins; Proteins - immunology; Respiratory syncytial virus; Respiratory Syncytial Virus Infections - immunology; Respiratory Syncytial Virus Infections - virology; Respiratory Syncytial Virus Vaccines; Respiratory Syncytial Virus, Human - genetics; Respiratory Syncytial Virus, Human - immunology; Respiratory Syncytial Virus, Human - pathogenicity; Respiratory tract; Respiratory tract diseases; Science; Science (multidisciplinary); Secondary structure; Viral Fusion Proteins - genetics; Viral Fusion Proteins - immunology

Human respiratory syncytial virus (RSV) is one of the most important causes of severe respiratory tract infections in early childhood. The only prophylactic protection is the neutralizing antibody, palivizumab, which targets a conformational epitope of the RSV fusion (F) protein. The F protein is ge...