Effect of FXR agonist GW4064 in the treatment of hilar cholangiocarcinoma in rats

• Published in: Scientific reports Vol. 12; no. 1; pp. 18873 - 9
• Main Authors: Wang, Jie-ping, Zhang, Meng-yu, Luo, Ming, Qin, Shu, Xia, Xian-ming
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.11.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67; 631/67/2195; Agonists; Animal models; Animals; Antibodies; Bile Duct Neoplasms - drug therapy; Bile ducts; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Gene therapy; Glyceraldehyde-3-phosphate dehydrogenase; Humanities and Social Sciences; Immunohistochemistry; Klatskin Tumor; Male; mRNA; multidisciplinary; NF-κB protein; Ntcp protein; Polymerase chain reaction; Proteins; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rodents; Science; Science (multidisciplinary); Therapeutic applications; Therapeutic targets; Tumors

The study objective was to observe the treatment effect of the farnesoid X receptor (FXR) agonist GW4064 in a rat model of hilar cholangiocarcinoma to explore a new therapeutic target for gene therapy for hilar cholangiocarcinoma. Eighty male Wistar rats were randomly divided into four groups (treat...