Protective role of VEGF/VEGFR2 signaling against high fatality associated with hepatic encephalopathy via sustaining mitochondrial bioenergetics functions

• Published in: Journal of biomedical science Vol. 29; no. 1; pp. 1 - 14
• Main Authors: Tsai, Ching-Yi, Wu, Jacqueline C. C., Wu, Chiung-Ju, Chan, Samuel H. H.
• Format: Journal Article
• Language: English
• Published: Basel BioMed Central Ltd 03.07.2022; BioMed Central; BMC
• Subjects: Acute liver failure; Ammonium; Ammonium chloride; Ammonium compounds; Ammonium paratungstate; Analysis; Angiogenesis; Animal experimentation; Apoptosis; Azoxymethane; Baroreceptors; Baroreflex dysregulation; Bioenergetics; Bioenergetics failure; Blood pressure; Cell death; Cell viability; Endothelial growth factors; Experiments; Fatalities; Gene expression; Growth factors; Health aspects; Hepatic encephalopathy; Hippocampus; Hypotension; Hypotheses; Kinases; Laboratory animals; Liver; Medical prognosis; Medulla oblongata; Membrane potential; Membrane proteins; Metabolism; Metabolites; Mice; Mitochondria; Mitochondrial membrane potential; Mortality; mRNA; Mutation; Neurological complications; Neurons; Neuroprotection; Physiological aspects; Physiology; Primary neuronal culture; Proteins; Reagents; Reduction; Reflexes; Signaling; Survival; Toxins; Vascular endothelial growth factor; United States > US

Background The lack of better understanding of the pathophysiology and cellular mechanisms associated with high mortality seen in hepatic encephalopathy (HE), a neurological complication arising from acute hepatic failure, remains a challenging medical issue. Clinical reports showed that the degree...