Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis

• Published in: Nature communications Vol. 13; no. 1; p. 7600
• Main Authors: Zhao, Min, Shao, Fei, Yu, Dou, Zhang, Jiaqi, Liu, Zhen, Ma, Jiangwen, Xia, Pengyan, Wang, Shuo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.12.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/21; 13/31; 38/91; 631/250/127/98; 631/250/2152/1566/1572; 631/250/2502; 631/250/2504/2506; 631/250/347; Allergens; Animals; CCR2 protein; Cell migration; Cytokines; Digestive system; Gastrointestinal tract; Homeostasis; Humanities and Social Sciences; Immunity, Innate; Inflammation; Intestine; Lung; Lungs; Lymphocytes; Lymphoid cells; Maturation; Mice; Monocyte chemoattractant protein 1; Mucosa; multidisciplinary; Phenotypes; Science; Science (multidisciplinary); Small intestine; Translocation

Innate lymphoid cells (ILC) are abundant in mucosal tissues. They serve critical functions in anti-pathogen response and tissue homeostasis. However, the heterogenous composition of ILCs in mucosal sites and their various maturation trajectories are less well known. In this study, we characterize IL...