The role of histone methylation in the development of digestive cancers: a potential direction for cancer management

Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and mortality. Histone methylation, which is mediated mainly by lysine methyltransferases, lysine demethylases, and protein arginine methyltransferases, has emerged as an essential mechanism re...

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Published inSignal transduction and targeted therapy Vol. 5; no. 1; p. 143
Main Authors Chen, Yuan, Ren, Bo, Yang, Jinshou, Wang, Huanyu, Yang, Gang, Xu, Ruiyuan, You, Lei, Zhao, Yupei
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 03.08.2020
Nature Publishing Group
Subjects
631/67/1059/153
631/67/1504
631/67/68
631/67/69
692/4020/1503/1504
Cancer
Cancer Research
Cell Biology
Colorectal cancer
Gastric cancer
Internal Medicine
Liver cancer
Medicine
Medicine & Public Health
Oncology
Pancreatic cancer
Pathology
Review
Review Article
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Abstract Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and mortality. Histone methylation, which is mediated mainly by lysine methyltransferases, lysine demethylases, and protein arginine methyltransferases, has emerged as an essential mechanism regulating pathological processes in digestive cancers. Under certain conditions, aberrant expression of these modifiers leads to abnormal histone methylation or demethylation in the corresponding cancer-related genes, which contributes to different processes and phenotypes, such as carcinogenesis, proliferation, metabolic reprogramming, epithelial–mesenchymal transition, invasion, and migration, during digestive cancer development. In this review, we focus on the association between histone methylation regulation and the development of digestive cancers, including gastric cancer, liver cancer, pancreatic cancer, and colorectal cancer, as well as on its clinical application prospects, aiming to provide a new perspective on the management of digestive cancers.
AbstractList Abstract Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and mortality. Histone methylation, which is mediated mainly by lysine methyltransferases, lysine demethylases, and protein arginine methyltransferases, has emerged as an essential mechanism regulating pathological processes in digestive cancers. Under certain conditions, aberrant expression of these modifiers leads to abnormal histone methylation or demethylation in the corresponding cancer-related genes, which contributes to different processes and phenotypes, such as carcinogenesis, proliferation, metabolic reprogramming, epithelial–mesenchymal transition, invasion, and migration, during digestive cancer development. In this review, we focus on the association between histone methylation regulation and the development of digestive cancers, including gastric cancer, liver cancer, pancreatic cancer, and colorectal cancer, as well as on its clinical application prospects, aiming to provide a new perspective on the management of digestive cancers.
Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and mortality. Histone methylation, which is mediated mainly by lysine methyltransferases, lysine demethylases, and protein arginine methyltransferases, has emerged as an essential mechanism regulating pathological processes in digestive cancers. Under certain conditions, aberrant expression of these modifiers leads to abnormal histone methylation or demethylation in the corresponding cancer-related genes, which contributes to different processes and phenotypes, such as carcinogenesis, proliferation, metabolic reprogramming, epithelial–mesenchymal transition, invasion, and migration, during digestive cancer development. In this review, we focus on the association between histone methylation regulation and the development of digestive cancers, including gastric cancer, liver cancer, pancreatic cancer, and colorectal cancer, as well as on its clinical application prospects, aiming to provide a new perspective on the management of digestive cancers.
ArticleNumber 143
Author Yang, Jinshou
You, Lei
Xu, Ruiyuan
Chen, Yuan
Ren, Bo
Wang, Huanyu
Yang, Gang
Zhao, Yupei
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ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7398912
proquest_journals_2429922134
crossref_primary_10_1038_s41392_020_00252_1
pubmed_primary_32747629
springer_journals_10_1038_s41392_020_00252_1
PublicationCentury 2000
PublicationDate 2020-08-03
PublicationDateYYYYMMDD 2020-08-03
PublicationDate_xml – month: 08
  year: 2020
  text: 2020-08-03
  day: 03
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Signal transduction and targeted therapy
PublicationTitleAbbrev Sig Transduct Target Ther
PublicationTitleAlternate Signal Transduct Target Ther
PublicationYear 2020
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
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Snippet Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and mortality. Histone methylation, which is...
Abstract Digestive cancers are the leading cause of cancer-related death worldwide and have high risks of morbidity and mortality. Histone methylation, which...
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SubjectTerms 631/67/1059/153
631/67/1504
631/67/68
631/67/69
692/4020/1503/1504
Cancer
Cancer Research
Cell Biology
Colorectal cancer
Gastric cancer
Internal Medicine
Liver cancer
Medicine
Medicine & Public Health
Oncology
Pancreatic cancer
Pathology
Review
Review Article
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Title The role of histone methylation in the development of digestive cancers: a potential direction for cancer management
URI https://link.springer.com/article/10.1038/s41392-020-00252-1
https://www.ncbi.nlm.nih.gov/pubmed/32747629
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