Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer

• Published in: Scientific reports Vol. 11; no. 1; pp. 18930 - 12
• Main Authors: Presa, Daniela, Khurram, Syed A., Zubir, Amir Z. A., Smarakan, Sneha, Cooper, Patricia A., Morais, Goreti R., Sadiq, Maria, Sutherland, Mark, Loadman, Paul M., McCaul, James, Shnyder, Steven D., Patterson, Laurence H., Pors, Klaus
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154; 631/67; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Carcinogens; Cell Line, Tumor; Cohort Studies; Cytochrome; Cytochrome P-450 CYP1A1 - antagonists & inhibitors; Cytochrome P-450 CYP1A1 - metabolism; Cytochrome P-450 CYP1B1 - antagonists & inhibitors; Cytochrome P-450 CYP1B1 - metabolism; Cytochrome P450; Cytochrome P450 Family 2 - antagonists & inhibitors; Cytochrome P450 Family 2 - metabolism; Epidemiology; Female; Head & neck cancer; Head and Neck Neoplasms - drug therapy; Head and Neck Neoplasms - pathology; Heterocyclic Compounds, 3-Ring - pharmacology; Heterocyclic Compounds, 3-Ring - therapeutic use; Humanities and Social Sciences; Humans; Indoles - pharmacology; Indoles - therapeutic use; Isoforms; Metabolic activation; Metabolic rate; Mice; multidisciplinary; Prodrugs; Prodrugs - pharmacology; Prodrugs - therapeutic use; Pyrroles - pharmacology; Pyrroles - therapeutic use; Science; Science (multidisciplinary); Tumors; Xenograft Model Antitumor Assays; Xenografts; United States > US; Detroit Michigan

Epidemiological studies have shown that head and neck cancer (HNC) is a complex multistage process that in part involves exposure to a combination of carcinogens and the capacity of certain drug-metabolising enzymes including cytochrome P450 (CYP) to detoxify or activate such carcinogens. In this st...