Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification

• Published in: Scientific reports Vol. 11; no. 1; pp. 18964 - 12
• Main Authors: Borkowski, Kamil, Taha, Ameer Y., Pedersen, Theresa L., De Jager, Philip L., Bennett, David A., Arnold, Matthias, Kaddurah-Daouk, Rima, Newman, John W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/2612; 692/499; 692/699/375/132; 692/699/375/132/1283; Aged; Aged, 80 and over; Aging; Aging - blood; Aging - metabolism; Algorithms; Bile acids; Bile Acids and Salts - blood; Bile Acids and Salts - metabolism; Biomarkers; Biomarkers - blood; Biomarkers - metabolism; Cannabinoids; Cognition - physiology; Cognitive ability; Cognitive Dysfunction - blood; Cognitive Dysfunction - diagnosis; Cognitive Dysfunction - metabolism; Dementia disorders; Endocannabinoids - blood; Endocannabinoids - metabolism; Energy metabolism; Epoxide hydrolase; Fasting; Fasting - blood; Fasting - metabolism; Female; Hormones; Humanities and Social Sciences; Humans; Linoleic acid; Male; Metabolism; Metabolites; Metabolomics; Metabolomics - methods; multidisciplinary; Oxylipins - blood; Oxylipins - metabolism; Science; Science (multidisciplinary); Steroid hormones

Cognitive decline is associated with both normal aging and early pathologies leading to dementia. Here we used quantitative profiling of metabolites involved in the regulation of inflammation, vascular function, neuronal function and energy metabolism, including oxylipins, endocannabinoids, bile aci...