The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens

• Published in: NPJ digital medicine Vol. 5; no. 1; pp. 83 - 12
• Main Authors: Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C. B., Wong, John Eu-Li, Tan, Gek-Yen Gladys, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.06.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 692/699/255/2514; Artificial intelligence; Biomedicine; Biotechnology; Combination therapy; Coronaviruses; COVID-19; Digital technology; Drug efficacy; Emergency preparedness; Medicine; Medicine & Public Health; Pandemics; Severe acute respiratory syndrome coronavirus 2

IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic op...