The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens

IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic op...

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Published inNPJ digital medicine Vol. 5; no. 1; pp. 83 - 12
Main Authors Blasiak, Agata, Truong, Anh T. L., Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T. P., Lye, David C. B., Wong, John Eu-Li, Tan, Gek-Yen Gladys, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 30.06.2022
Nature Publishing Group
Nature Portfolio
Subjects
631/114
692/699/255/2514
Artificial intelligence
Biomedicine
Biotechnology
Combination therapy
Coronaviruses
COVID-19
Digital technology
Drug efficacy
Emergency preparedness
Medicine
Medicine & Public Health
Pandemics
Severe acute respiratory syndrome coronavirus 2
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Abstract IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic optimization workflow. A starting pool of 12 candidate drugs developed in collaboration with a community of infectious disease clinicians was first narrowed down to a six-drug pool and then interrogated in 50 combination regimens at three dosing levels per drug, representing 729 possible combinations. IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). IDentif.AI-x prioritized promising drug combinations for clinical translation and can be immediately adjusted and re-executed with a new pool of promising therapies in an actionable path towards rapidly optimizing combination therapy following pandemic emergence.
AbstractList IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic optimization workflow. A starting pool of 12 candidate drugs developed in collaboration with a community of infectious disease clinicians was first narrowed down to a six-drug pool and then interrogated in 50 combination regimens at three dosing levels per drug, representing 729 possible combinations. IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). IDentif.AI-x prioritized promising drug combinations for clinical translation and can be immediately adjusted and re-executed with a new pool of promising therapies in an actionable path towards rapidly optimizing combination therapy following pandemic emergence.IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic optimization workflow. A starting pool of 12 candidate drugs developed in collaboration with a community of infectious disease clinicians was first narrowed down to a six-drug pool and then interrogated in 50 combination regimens at three dosing levels per drug, representing 729 possible combinations. IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). IDentif.AI-x prioritized promising drug combinations for clinical translation and can be immediately adjusted and re-executed with a new pool of promising therapies in an actionable path towards rapidly optimizing combination therapy following pandemic emergence.
IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic optimization workflow. A starting pool of 12 candidate drugs developed in collaboration with a community of infectious disease clinicians was first narrowed down to a six-drug pool and then interrogated in 50 combination regimens at three dosing levels per drug, representing 729 possible combinations. IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). IDentif.AI-x prioritized promising drug combinations for clinical translation and can be immediately adjusted and re-executed with a new pool of promising therapies in an actionable path towards rapidly optimizing combination therapy following pandemic emergence.
Abstract IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against COVID-19 by pairing a prospective, experimental validation of multi-drug efficacy on a SARS-CoV-2 live virus and Vero E6 assay with a quadratic optimization workflow. A starting pool of 12 candidate drugs developed in collaboration with a community of infectious disease clinicians was first narrowed down to a six-drug pool and then interrogated in 50 combination regimens at three dosing levels per drug, representing 729 possible combinations. IDentif.AI-x revealed EIDD-1931 to be a strong candidate upon which multiple drug combinations can be derived, and pinpointed a number of clinically actionable drug interactions, which were further reconfirmed in SARS-CoV-2 variants B.1.351 (Beta) and B.1.617.2 (Delta). IDentif.AI-x prioritized promising drug combinations for clinical translation and can be immediately adjusted and re-executed with a new pool of promising therapies in an actionable path towards rapidly optimizing combination therapy following pandemic emergence.
ArticleNumber 83
Author Blasiak, Agata
Allen, David Michael
Chan, Conrad En Zuo
Wang, Peter
Chye, De Hoe
Lim, Angeline Pei Chiew
Teo, Swee Teng
Seah, Shirley Gek Kheng
Chng, Wee Joo
Ho, Dean
Lin, Raymond T. P.
Lye, David C. B.
Wong, John Eu-Li
Hooi, Lissa
Chow, Edward Kai-Hua
Tan, Yee-Joo
Chai, Louis Yi Ann
Remus, Alexandria
Tan, Gek-Yen Gladys
Truong, Anh T. L.
Ng, Kim Tien
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  organization: The Institute for Digital Medicine (WisDM), Yong Loo Lin School of Medicine, National University of Singapore, The N.1 Institute for Health (N.1), National University of Singapore, Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore
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– sequence: 10
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  surname: Chng
  fullname: Chng, Wee Joo
  organization: Cancer Science Institute of Singapore, National University of Singapore, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Hospital, NUS Centre for Cancer Research (N2CR), Yong Loo Lin School of Medicine, National University of Singapore
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  givenname: John Eu-Li
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Cites_doi 10.1016/S1473-3099(20)30132-8
10.1080/00031305.2019.1583913
10.1001/jama.2020.3204
10.1073/pnas.1600812113
10.1371/journal.pone.0215607
10.15252/emmm.202012697
10.1038/s41586-021-03312-w
10.1056/NEJMoa2031994
10.1038/s41598-021-88153-3
10.1016/j.csbj.2020.03.025
10.1021/acs.jmedchem.0c00502
10.1056/NEJMoa2015301
10.1073/pnas.2105815118
10.1021/acsnano.5b00638
10.1038/s41586-020-2577-1
10.1016/j.ijsu.2020.10.018
10.1016/S0140-6736(21)00461-X
10.1371/journal.pone.0241543
10.1073/pnas.1606301113
10.1126/science.abg5827
10.1002/adtp.201800104
10.1016/j.mehy.2020.110180
10.1016/S2213-2600(21)00237-X
10.1016/j.ejca.2020.09.014
10.1177/2211068215579612
10.1016/S2214-109X(21)00251-5
10.1002/adtp.201900122
10.7326/M20-8179
10.1002/cpt.1909
10.1016/S0140-6736(20)30304-4
10.1126/science.aaz3023
10.1038/s41467-021-22580-8
10.1126/science.abf4058
10.1056/NEJMoa2007764
10.7326/M21-0653
10.1038/s43588-020-00007-6
10.1002/btm2.10196
10.1016/j.eclinm.2020.100539
10.1056/NEJMoa2023184
10.1002/adtp.201900114
10.1002/adtp.202000034
10.1038/s41540-018-0069-9
10.1038/s41408-020-0276-7
10.1136/bmj.n2422
10.1038/ncomms14183
10.1038/s41564-020-00835-2
10.1016/j.tibtech.2019.12.021
10.1177/2472630319890316
10.1186/1752-0509-5-88
10.1016/j.str.2020.10.007
10.1056/NEJMoa2021436
10.1073/pnas.0800823105
10.1073/pnas.2025581118
10.5705/ss.2012.210.
10.1126/scitranslmed.abb5883
10.1126/scitranslmed.aac5954
10.3389/fdgth.2021.635524
10.1002/adtp.201900023
10.1101/2021.06.24.449811
10.1001/jama.2019.20153
10.1038/s41467-020-18710-3
10.1126/scitranslmed.aan0941
10.1128/AAC.02428-20
10.1093/jac/dkab318
10.1126/scitranslmed.abl7430
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References Martínez-Sanz, Pérez-Molina, Moreno, Zamora, Serrano-Villar (CR59) 2020; 27
Blasiak, Khong, Kee (CR33) 2020; 25
de Mel (CR32) 2020; 10
Arshad (CR67) 2020; 108
Aman (CR57) 2021; 9
Al-Shyoukh (CR15) 2011; 5
Metlay, Armstrong (CR60) 2021; 174
Drayman (CR37) 2021; 373
Barratt-Due (CR56) 2021; 174
Mongia, Saha, Chouzenoux, Majumdar (CR12) 2021; 11
El Bairi (CR41) 2020; 141
Young (CR66) 2020; 323
CR31
Lovetrue (CR44) 2020; 144
Pantuck (CR30) 2018; 1
Kalil (CR8) 2021; 384
CR4
Blasiak (CR19) 2021; 6
CR5
Wasserstein, Schirm, Lazar (CR70) 2019; 73
Wahl (CR49) 2021; 591
Mohapatra (CR11) 2020; 15
Mohd Abdul Rashid (CR17) 2015; 20
Stebbing (CR63) 2020; 20
CR47
CR46
Mirabelli (CR2) 2021; 118
White (CR3) 2021; 371
Wang (CR16) 2015; 9
Riva (CR1) 2020; 586
(CR6) 2021; 397
Tekin (CR9) 2018; 4
Zimmer, Katzir, Dekel, Mayo, Alon (CR13) 2016; 113
Richardson (CR39) 2020; 395
Ho (CR22) 2020; 38
Stebbing (CR35) 2020; 12
(CR7) 2021; 384
Ho (CR21) 2020; 367
Mahase (CR51) 2021; 375
CR58
Wong (CR18) 2008; 105
Abdulla (CR14) 2020; 3
Xiu (CR36) 2020; 63
CR54
CR53
CR52
CR50
Farrance, Frenkel (CR69) 2012; 33
Beck, Shin, Choi, Park, Kang (CR65) 2020; 18
Haritha, Sharun, Jose (CR42) 2020; 84
Cox, Wolf, Plemper (CR40) 2021; 6
Kneller (CR43) 2020; 28
Goldman (CR38) 2020; 383
CR28
CR27
Strohbehn, Parker, Reid, Gellad (CR62) 2021; 9
CR25
(CR55) 2021; 384
Shen (CR29) 2020; 3
CR68
Lee (CR23) 2017; 8
Rosenke (CR48) 2021; 12
CR64
Sanders, Monogue, Jodlowski, Cutrell (CR45) 2020; 323
Galindez (CR10) 2021; 1
CR61
Lim, Goh, Rashid, Chow (CR24) 2020; 3
Beigel (CR34) 2020; 383
Silva (CR26) 2016; 113
Clemens (CR20) 2019; 14
MB Mohd Abdul Rashid (627_CR17) 2015; 20
JJ Lim (627_CR24) 2020; 3
627_CR61
BE Young (627_CR66) 2020; 323
PRINCIPLE Trial Collaborative Group et al. (627_CR6) 2021; 397
A Zimmer (627_CR13) 2016; 113
A Blasiak (627_CR19) 2021; 6
S Xiu (627_CR36) 2020; 63
627_CR28
627_CR27
RM Cox (627_CR40) 2021; 6
KM White (627_CR3) 2021; 371
Y Shen (627_CR29) 2020; 3
627_CR64
627_CR25
627_CR68
J Aman (627_CR57) 2021; 9
RECOVERY Collaborative Group et al. (627_CR7) 2021; 384
627_CR50
E Tekin (627_CR9) 2018; 4
RL Wasserstein (627_CR70) 2019; 73
A Mongia (627_CR12) 2021; 11
G Galindez (627_CR10) 2021; 1
JH Beigel (627_CR34) 2020; 383
JD Goldman (627_CR38) 2020; 383
DW Kneller (627_CR43) 2020; 28
N Drayman (627_CR37) 2021; 373
627_CR54
I Al-Shyoukh (627_CR15) 2011; 5
627_CR53
627_CR52
H Wang (627_CR16) 2015; 9
627_CR58
J Martínez-Sanz (627_CR59) 2020; 27
GW Strohbehn (627_CR62) 2021; 9
BY Lee (627_CR23) 2017; 8
U Arshad (627_CR67) 2020; 108
PK Wong (627_CR18) 2008; 105
JM Sanders (627_CR45) 2020; 323
B Lovetrue (627_CR44) 2020; 144
A Silva (627_CR26) 2016; 113
A Blasiak (627_CR33) 2020; 25
BR Beck (627_CR65) 2020; 18
DL Clemens (627_CR20) 2019; 14
S Mohapatra (627_CR11) 2020; 15
E Mahase (627_CR51) 2021; 375
A Barratt-Due (627_CR56) 2021; 174
627_CR47
627_CR46
J Stebbing (627_CR35) 2020; 12
JP Metlay (627_CR60) 2021; 174
K El Bairi (627_CR41) 2020; 141
AC Kalil (627_CR8) 2021; 384
AJ Pantuck (627_CR30) 2018; 1
CV Haritha (627_CR42) 2020; 84
A Abdulla (627_CR14) 2020; 3
D Ho (627_CR21) 2020; 367
C Mirabelli (627_CR2) 2021; 118
A Wahl (627_CR49) 2021; 591
627_CR5
627_CR4
WHO Solidarity Trial Consortium. (627_CR55) 2021; 384
I Farrance (627_CR69) 2012; 33
627_CR31
J Stebbing (627_CR63) 2020; 20
L Riva (627_CR1) 2020; 586
P Richardson (627_CR39) 2020; 395
D Ho (627_CR22) 2020; 38
K Rosenke (627_CR48) 2021; 12
S de Mel (627_CR32) 2020; 10
References_xml – volume: 20
  start-page: 400
  year: 2020
  end-page: 402
  ident: CR63
  article-title: COVID-19: combining antiviral and anti-inflammatory treatments
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(20)30132-8
  contributor:
    fullname: Stebbing
– volume: 73
  start-page: 1
  year: 2019
  end-page: 19
  ident: CR70
  article-title: Moving to a World Beyond “p < 0.05”
  publication-title: Am. Stat.
  doi: 10.1080/00031305.2019.1583913
  contributor:
    fullname: Lazar
– volume: 323
  start-page: 1488
  year: 2020
  end-page: 1494
  ident: CR66
  article-title: Epidemiologic Features and Clinical Course of Patients Infected With SARS-CoV-2 in Singapore
  publication-title: JAMA
  doi: 10.1001/jama.2020.3204
  contributor:
    fullname: Young
– volume: 113
  start-page: E2172
  year: 2016
  end-page: E2179
  ident: CR26
  article-title: Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1600812113
  contributor:
    fullname: Silva
– volume: 14
  start-page: e0215607
  year: 2019
  ident: CR20
  article-title: Artificial intelligence enabled parabolic response surface platform identifies ultra-rapid near-universal TB drug treatment regimens comprising approved drugs
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0215607
  contributor:
    fullname: Clemens
– ident: CR68
– ident: CR4
– volume: 12
  start-page: e12697
  year: 2020
  ident: CR35
  article-title: Mechanism of baricitinib supports artificial intelligence-predicted testing in COVID -19 patients
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.202012697
  contributor:
    fullname: Stebbing
– volume: 591
  start-page: 451
  year: 2021
  end-page: 457
  ident: CR49
  article-title: SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
  publication-title: Nature
  doi: 10.1038/s41586-021-03312-w
  contributor:
    fullname: Wahl
– volume: 384
  start-page: 795
  year: 2021
  end-page: 807
  ident: CR8
  article-title: Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2031994
  contributor:
    fullname: Kalil
– volume: 11
  year: 2021
  ident: CR12
  article-title: A computational approach to aid clinicians in selecting anti-viral drugs for COVID-19 trials
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-88153-3
  contributor:
    fullname: Majumdar
– ident: CR54
– ident: CR61
– volume: 18
  start-page: 784
  year: 2020
  end-page: 790
  ident: CR65
  article-title: Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model
  publication-title: Comput. Struct. Biotechnol. J.
  doi: 10.1016/j.csbj.2020.03.025
  contributor:
    fullname: Kang
– ident: CR58
– volume: 63
  start-page: 12256
  year: 2020
  end-page: 12274
  ident: CR36
  article-title: Inhibitors of SARS-CoV-2 Entry: Current and Future Opportunities
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.0c00502
  contributor:
    fullname: Xiu
– volume: 383
  start-page: 1827
  year: 2020
  end-page: 1837
  ident: CR38
  article-title: Remdesivir for 5 or 10 Days in Patients with Severe Covid-19
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2015301
  contributor:
    fullname: Goldman
– volume: 118
  start-page: e2105815118
  year: 2021
  ident: CR2
  article-title: Morphological cell profiling of SARS-CoV-2 infection identifies drug repurposing candidates for COVID-19
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.2105815118
  contributor:
    fullname: Mirabelli
– ident: CR25
– volume: 9
  start-page: 3332
  year: 2015
  end-page: 3344
  ident: CR16
  article-title: Mechanism-independent optimization of combinatorial nanodiamond and unmodified drug delivery using a phenotypically driven platform technology
  publication-title: ACS Nano
  doi: 10.1021/acsnano.5b00638
  contributor:
    fullname: Wang
– volume: 586
  start-page: 113
  year: 2020
  end-page: 119
  ident: CR1
  article-title: Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing
  publication-title: Nature
  doi: 10.1038/s41586-020-2577-1
  contributor:
    fullname: Riva
– volume: 84
  start-page: 53
  year: 2020
  end-page: 56
  ident: CR42
  article-title: Ebselen, a new candidate therapeutic against SARS-CoV-2
  publication-title: Int. J. Surg.
  doi: 10.1016/j.ijsu.2020.10.018
  contributor:
    fullname: Jose
– volume: 397
  start-page: 1063
  year: 2021
  end-page: 1074
  ident: CR6
  article-title: Azithromycin for community treatment of suspected COVID-19 in people at increased risk of an adverse clinical course in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)00461-X
– volume: 15
  start-page: e0241543
  year: 2020
  ident: CR11
  article-title: Repurposing therapeutics for COVID-19: Rapid prediction of commercially available drugs through machine learning and docking
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0241543
  contributor:
    fullname: Mohapatra
– volume: 113
  start-page: 10442
  year: 2016
  end-page: 10447
  ident: CR13
  article-title: Prediction of multidimensional drug dose responses based on measurements of drug pairs
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1606301113
  contributor:
    fullname: Alon
– ident: CR46
– volume: 373
  start-page: 931
  year: 2021
  end-page: 936
  ident: CR37
  article-title: Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2
  publication-title: Science
  doi: 10.1126/science.abg5827
  contributor:
    fullname: Drayman
– volume: 33
  start-page: 49
  year: 2012
  end-page: 75
  ident: CR69
  article-title: Uncertainty of Measurement: A Review of the Rules for Calculating Uncertainty Components through Functional Relationships
  publication-title: Clin. Biochem Rev.
  contributor:
    fullname: Frenkel
– volume: 1
  start-page: 1800104
  year: 2018
  ident: CR30
  article-title: Modulating BET Bromodomain Inhibitor ZEN-3694 and Enzalutamide Combination Dosing in a Metastatic Prostate Cancer Patient Using CURATE.AI, an Artificial Intelligence Platform
  publication-title: Adv. Ther.
  doi: 10.1002/adtp.201800104
  contributor:
    fullname: Pantuck
– ident: CR50
– volume: 144
  start-page: 110180
  year: 2020
  ident: CR44
  article-title: The AI-discovered aetiology of COVID-19 and rationale of the irinotecan+ etoposide combination therapy for critically ill COVID-19 patients
  publication-title: Med. Hypotheses
  doi: 10.1016/j.mehy.2020.110180
  contributor:
    fullname: Lovetrue
– volume: 9
  start-page: 957
  year: 2021
  end-page: 968
  ident: CR57
  article-title: Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial
  publication-title: Lancet Respir. Med.
  doi: 10.1016/S2213-2600(21)00237-X
  contributor:
    fullname: Aman
– ident: CR5
– volume: 141
  start-page: 40
  year: 2020
  end-page: 61
  ident: CR41
  article-title: Repurposing anticancer drugs for the management of COVID-19
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2020.09.014
  contributor:
    fullname: El Bairi
– ident: CR64
– volume: 20
  start-page: 423
  year: 2015
  end-page: 437
  ident: CR17
  article-title: Identification and Optimization of Combinatorial Glucose Metabolism Inhibitors in Hepatocellular Carcinomas
  publication-title: J. Lab. Autom.
  doi: 10.1177/2211068215579612
  contributor:
    fullname: Mohd Abdul Rashid
– volume: 9
  start-page: e1049
  year: 2021
  end-page: e1050
  ident: CR62
  article-title: Socially optimal pandemic drug dosing
  publication-title: Lancet Glob. Heal
  doi: 10.1016/S2214-109X(21)00251-5
  contributor:
    fullname: Gellad
– volume: 3
  start-page: 1900122
  year: 2020
  ident: CR24
  article-title: Maximizing Efficiency of Artificial Intelligence-Driven Drug Combination Optimization through Minimal Resolution Experimental Design
  publication-title: Adv. Ther.
  doi: 10.1002/adtp.201900122
  contributor:
    fullname: Chow
– volume: 323
  start-page: 1824
  year: 2020
  end-page: 1836
  ident: CR45
  article-title: Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review
  publication-title: JAMA - J. Am. Med. Assoc.
  contributor:
    fullname: Cutrell
– volume: 174
  start-page: 691
  year: 2021
  end-page: 693
  ident: CR60
  article-title: Clinical Decision Making During the COVID-19 Pandemic
  publication-title: Ann. Intern. Med.
  doi: 10.7326/M20-8179
  contributor:
    fullname: Armstrong
– volume: 108
  start-page: 775
  year: 2020
  end-page: 790
  ident: CR67
  article-title: Prioritization of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1002/cpt.1909
  contributor:
    fullname: Arshad
– volume: 395
  start-page: e30
  year: 2020
  end-page: e31
  ident: CR39
  article-title: Baricitinib as potential treatment for 2019-nCoV acute respiratory disease
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30304-4
  contributor:
    fullname: Richardson
– ident: CR47
– volume: 367
  start-page: 982
  year: 2020
  end-page: 983
  ident: CR21
  article-title: Artificial intelligence in cancer therapy
  publication-title: Science
  doi: 10.1126/science.aaz3023
  contributor:
    fullname: Ho
– volume: 12
  year: 2021
  ident: CR48
  article-title: Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-22580-8
  contributor:
    fullname: Rosenke
– volume: 371
  start-page: 926
  year: 2021
  end-page: 931
  ident: CR3
  article-title: Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
  publication-title: Science
  doi: 10.1126/science.abf4058
  contributor:
    fullname: White
– volume: 383
  start-page: 1813
  year: 2020
  end-page: 1826
  ident: CR34
  article-title: Remdesivir for the Treatment of Covid-19 — Final Report
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2007764
  contributor:
    fullname: Beigel
– volume: 174
  start-page: 1261
  year: 2021
  end-page: 1269
  ident: CR56
  article-title: Evaluation of the effects of remdesivir and hydroxychloroquine on viral clearance in covid-19: A randomized trial
  publication-title: Ann. Intern. Med.
  doi: 10.7326/M21-0653
  contributor:
    fullname: Barratt-Due
– ident: CR53
– volume: 1
  start-page: 33
  year: 2021
  end-page: 41
  ident: CR10
  article-title: Lessons from the COVID-19 pandemic for advancing computational drug repurposing strategies
  publication-title: Nat. Comput. Sci.
  doi: 10.1038/s43588-020-00007-6
  contributor:
    fullname: Galindez
– volume: 6
  start-page: e10196
  year: 2021
  ident: CR19
  article-title: IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) with digital drug development
  publication-title: Bioeng. Transl. Med.
  doi: 10.1002/btm2.10196
  contributor:
    fullname: Blasiak
– volume: 27
  start-page: 100539
  year: 2020
  ident: CR59
  article-title: Understanding clinical decision-making during the COVID-19 pandemic: A cross-sectional worldwide survey
  publication-title: EClinicalMedicine
  doi: 10.1016/j.eclinm.2020.100539
  contributor:
    fullname: Serrano-Villar
– volume: 384
  start-page: 497
  year: 2021
  end-page: 511
  ident: CR55
  article-title: Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2023184
– volume: 3
  start-page: 1900114
  year: 2020
  ident: CR29
  article-title: Harnessing Artificial Intelligence to Optimize Long-Term Maintenance Dosing for Antiretroviral-Naive Adults with HIV-1 Infection
  publication-title: Adv. Ther.
  doi: 10.1002/adtp.201900114
  contributor:
    fullname: Shen
– volume: 3
  start-page: 2000034
  year: 2020
  ident: CR14
  article-title: Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention
  publication-title: Adv. Ther.
  doi: 10.1002/adtp.202000034
  contributor:
    fullname: Abdulla
– ident: CR27
– volume: 4
  year: 2018
  ident: CR9
  article-title: Prevalence and patterns of higher-order drug interactions in Escherichia coli
  publication-title: npj Syst. Biol. Appl.
  doi: 10.1038/s41540-018-0069-9
  contributor:
    fullname: Tekin
– volume: 10
  year: 2020
  ident: CR32
  article-title: Application of an ex-vivo drug sensitivity platform towards achieving complete remission in a refractory T-cell lymphoma
  publication-title: Blood Cancer J.
  doi: 10.1038/s41408-020-0276-7
  contributor:
    fullname: de Mel
– volume: 375
  start-page: n2422
  year: 2021
  ident: CR51
  article-title: Covid-19: Molnupiravir reduces risk of hospital admission or death by 50% in patients at risk, MSD reports
  publication-title: BMJ
  doi: 10.1136/bmj.n2422
  contributor:
    fullname: Mahase
– ident: CR52
– volume: 8
  year: 2017
  ident: CR23
  article-title: Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14183
  contributor:
    fullname: Lee
– volume: 6
  start-page: 11
  year: 2021
  end-page: 18
  ident: CR40
  article-title: Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets
  publication-title: Nat. Microbiol.
  doi: 10.1038/s41564-020-00835-2
  contributor:
    fullname: Plemper
– ident: CR31
– volume: 38
  start-page: 497
  year: 2020
  end-page: 518
  ident: CR22
  article-title: Enabling Technologies for Personalized and Precision Medicine
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2019.12.021
  contributor:
    fullname: Ho
– volume: 25
  start-page: 95
  year: 2020
  end-page: 105
  ident: CR33
  article-title: CURATE.AI: Optimizing Personalized Medicine with
  publication-title: Artif. Intell. SLAS Technol.
  doi: 10.1177/2472630319890316
  contributor:
    fullname: Kee
– volume: 5
  year: 2011
  ident: CR15
  article-title: Systematic quantitative characterization of cellular responses induced by multiple signals
  publication-title: BMC Syst. Biol.
  doi: 10.1186/1752-0509-5-88
  contributor:
    fullname: Al-Shyoukh
– ident: CR28
– volume: 28
  start-page: 1313
  year: 2020
  end-page: 1320
  ident: CR43
  article-title: Malleability of the SARS-CoV-2 3CL Mpro Active-Site Cavity Facilitates Binding of Clinical Antivirals
  publication-title: Structure
  doi: 10.1016/j.str.2020.10.007
  contributor:
    fullname: Kneller
– volume: 384
  start-page: 693
  year: 2021
  end-page: 704
  ident: CR7
  article-title: Dexamethasone in Hospitalized Patients with Covid-19
  publication-title: N. Engl. J. Med
  doi: 10.1056/NEJMoa2021436
– volume: 105
  start-page: 5105
  year: 2008
  end-page: 5110
  ident: CR18
  article-title: Closed-loop control of cellular functions using combinatory drugs guided by a stochastic search algorithm
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0800823105
  contributor:
    fullname: Wong
– ident: 627_CR64
  doi: 10.1073/pnas.2025581118
– volume: 383
  start-page: 1813
  year: 2020
  ident: 627_CR34
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2007764
  contributor:
    fullname: JH Beigel
– volume: 18
  start-page: 784
  year: 2020
  ident: 627_CR65
  publication-title: Comput. Struct. Biotechnol. J.
  doi: 10.1016/j.csbj.2020.03.025
  contributor:
    fullname: BR Beck
– volume: 384
  start-page: 795
  year: 2021
  ident: 627_CR8
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2031994
  contributor:
    fullname: AC Kalil
– volume: 28
  start-page: 1313
  year: 2020
  ident: 627_CR43
  publication-title: Structure
  doi: 10.1016/j.str.2020.10.007
  contributor:
    fullname: DW Kneller
– volume: 27
  start-page: 100539
  year: 2020
  ident: 627_CR59
  publication-title: EClinicalMedicine
  doi: 10.1016/j.eclinm.2020.100539
  contributor:
    fullname: J Martínez-Sanz
– volume: 144
  start-page: 110180
  year: 2020
  ident: 627_CR44
  publication-title: Med. Hypotheses
  doi: 10.1016/j.mehy.2020.110180
  contributor:
    fullname: B Lovetrue
– volume: 373
  start-page: 931
  year: 2021
  ident: 627_CR37
  publication-title: Science
  doi: 10.1126/science.abg5827
  contributor:
    fullname: N Drayman
– ident: 627_CR54
– volume: 118
  start-page: e2105815118
  year: 2021
  ident: 627_CR2
  publication-title: Proc. Natl Acad. Sci.
  doi: 10.1073/pnas.2105815118
  contributor:
    fullname: C Mirabelli
– volume: 9
  start-page: 957
  year: 2021
  ident: 627_CR57
  publication-title: Lancet Respir. Med.
  doi: 10.1016/S2213-2600(21)00237-X
  contributor:
    fullname: J Aman
– volume: 371
  start-page: 926
  year: 2021
  ident: 627_CR3
  publication-title: Science
  doi: 10.1126/science.abf4058
  contributor:
    fullname: KM White
– volume: 586
  start-page: 113
  year: 2020
  ident: 627_CR1
  publication-title: Nature
  doi: 10.1038/s41586-020-2577-1
  contributor:
    fullname: L Riva
– volume: 1
  start-page: 1800104
  year: 2018
  ident: 627_CR30
  publication-title: Adv. Ther.
  doi: 10.1002/adtp.201800104
  contributor:
    fullname: AJ Pantuck
– volume: 12
  start-page: e12697
  year: 2020
  ident: 627_CR35
  publication-title: EMBO Mol. Med.
  doi: 10.15252/emmm.202012697
  contributor:
    fullname: J Stebbing
– volume: 108
  start-page: 775
  year: 2020
  ident: 627_CR67
  publication-title: Clin. Pharmacol. Ther.
  doi: 10.1002/cpt.1909
  contributor:
    fullname: U Arshad
– ident: 627_CR68
  doi: 10.5705/ss.2012.210.
– volume: 20
  start-page: 400
  year: 2020
  ident: 627_CR63
  publication-title: Lancet Infect. Dis.
  doi: 10.1016/S1473-3099(20)30132-8
  contributor:
    fullname: J Stebbing
– volume: 84
  start-page: 53
  year: 2020
  ident: 627_CR42
  publication-title: Int. J. Surg.
  doi: 10.1016/j.ijsu.2020.10.018
  contributor:
    fullname: CV Haritha
– ident: 627_CR4
  doi: 10.1126/scitranslmed.abb5883
– ident: 627_CR53
– volume: 5
  year: 2011
  ident: 627_CR15
  publication-title: BMC Syst. Biol.
  doi: 10.1186/1752-0509-5-88
  contributor:
    fullname: I Al-Shyoukh
– volume: 113
  start-page: E2172
  year: 2016
  ident: 627_CR26
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1600812113
  contributor:
    fullname: A Silva
– volume: 384
  start-page: 693
  year: 2021
  ident: 627_CR7
  publication-title: N. Engl. J. Med
  doi: 10.1056/NEJMoa2021436
  contributor:
    fullname: RECOVERY Collaborative Group et al.
– volume: 33
  start-page: 49
  year: 2012
  ident: 627_CR69
  publication-title: Clin. Biochem Rev.
  contributor:
    fullname: I Farrance
– volume: 174
  start-page: 691
  year: 2021
  ident: 627_CR60
  publication-title: Ann. Intern. Med.
  doi: 10.7326/M20-8179
  contributor:
    fullname: JP Metlay
– volume: 15
  start-page: e0241543
  year: 2020
  ident: 627_CR11
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0241543
  contributor:
    fullname: S Mohapatra
– volume: 3
  start-page: 2000034
  year: 2020
  ident: 627_CR14
  publication-title: Adv. Ther.
  doi: 10.1002/adtp.202000034
  contributor:
    fullname: A Abdulla
– volume: 395
  start-page: e30
  year: 2020
  ident: 627_CR39
  publication-title: Lancet
  doi: 10.1016/S0140-6736(20)30304-4
  contributor:
    fullname: P Richardson
– volume: 383
  start-page: 1827
  year: 2020
  ident: 627_CR38
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2015301
  contributor:
    fullname: JD Goldman
– volume: 6
  start-page: e10196
  year: 2021
  ident: 627_CR19
  publication-title: Bioeng. Transl. Med.
  doi: 10.1002/btm2.10196
  contributor:
    fullname: A Blasiak
– volume: 20
  start-page: 423
  year: 2015
  ident: 627_CR17
  publication-title: J. Lab. Autom.
  doi: 10.1177/2211068215579612
  contributor:
    fullname: MB Mohd Abdul Rashid
– ident: 627_CR27
  doi: 10.1126/scitranslmed.aac5954
– volume: 8
  year: 2017
  ident: 627_CR23
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14183
  contributor:
    fullname: BY Lee
– volume: 397
  start-page: 1063
  year: 2021
  ident: 627_CR6
  publication-title: Lancet
  doi: 10.1016/S0140-6736(21)00461-X
  contributor:
    fullname: PRINCIPLE Trial Collaborative Group et al.
– volume: 11
  year: 2021
  ident: 627_CR12
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-021-88153-3
  contributor:
    fullname: A Mongia
– volume: 38
  start-page: 497
  year: 2020
  ident: 627_CR22
  publication-title: Trends Biotechnol.
  doi: 10.1016/j.tibtech.2019.12.021
  contributor:
    fullname: D Ho
– volume: 105
  start-page: 5105
  year: 2008
  ident: 627_CR18
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0800823105
  contributor:
    fullname: PK Wong
– ident: 627_CR28
  doi: 10.3389/fdgth.2021.635524
– volume: 14
  start-page: e0215607
  year: 2019
  ident: 627_CR20
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0215607
  contributor:
    fullname: DL Clemens
– volume: 3
  start-page: 1900114
  year: 2020
  ident: 627_CR29
  publication-title: Adv. Ther.
  doi: 10.1002/adtp.201900114
  contributor:
    fullname: Y Shen
– ident: 627_CR31
  doi: 10.1002/adtp.201900023
– ident: 627_CR52
– volume: 10
  year: 2020
  ident: 627_CR32
  publication-title: Blood Cancer J.
  doi: 10.1038/s41408-020-0276-7
  contributor:
    fullname: S de Mel
– volume: 4
  year: 2018
  ident: 627_CR9
  publication-title: npj Syst. Biol. Appl.
  doi: 10.1038/s41540-018-0069-9
  contributor:
    fullname: E Tekin
– volume: 113
  start-page: 10442
  year: 2016
  ident: 627_CR13
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1606301113
  contributor:
    fullname: A Zimmer
– ident: 627_CR58
  doi: 10.1101/2021.06.24.449811
– volume: 323
  start-page: 1824
  year: 2020
  ident: 627_CR45
  publication-title: JAMA - J. Am. Med. Assoc.
  doi: 10.1001/jama.2019.20153
  contributor:
    fullname: JM Sanders
– ident: 627_CR61
– ident: 627_CR5
  doi: 10.1038/s41467-020-18710-3
– volume: 25
  start-page: 95
  year: 2020
  ident: 627_CR33
  publication-title: Artif. Intell. SLAS Technol.
  doi: 10.1177/2472630319890316
  contributor:
    fullname: A Blasiak
– ident: 627_CR25
  doi: 10.1126/scitranslmed.aan0941
– volume: 174
  start-page: 1261
  year: 2021
  ident: 627_CR56
  publication-title: Ann. Intern. Med.
  doi: 10.7326/M21-0653
  contributor:
    fullname: A Barratt-Due
– volume: 323
  start-page: 1488
  year: 2020
  ident: 627_CR66
  publication-title: JAMA
  doi: 10.1001/jama.2020.3204
  contributor:
    fullname: BE Young
– volume: 6
  start-page: 11
  year: 2021
  ident: 627_CR40
  publication-title: Nat. Microbiol.
  doi: 10.1038/s41564-020-00835-2
  contributor:
    fullname: RM Cox
– volume: 12
  year: 2021
  ident: 627_CR48
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-22580-8
  contributor:
    fullname: K Rosenke
– volume: 3
  start-page: 1900122
  year: 2020
  ident: 627_CR24
  publication-title: Adv. Ther.
  doi: 10.1002/adtp.201900122
  contributor:
    fullname: JJ Lim
– volume: 9
  start-page: e1049
  year: 2021
  ident: 627_CR62
  publication-title: Lancet Glob. Heal
  doi: 10.1016/S2214-109X(21)00251-5
  contributor:
    fullname: GW Strohbehn
– volume: 9
  start-page: 3332
  year: 2015
  ident: 627_CR16
  publication-title: ACS Nano
  doi: 10.1021/acsnano.5b00638
  contributor:
    fullname: H Wang
– volume: 591
  start-page: 451
  year: 2021
  ident: 627_CR49
  publication-title: Nature
  doi: 10.1038/s41586-021-03312-w
  contributor:
    fullname: A Wahl
– volume: 384
  start-page: 497
  year: 2021
  ident: 627_CR55
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2023184
  contributor:
    fullname: WHO Solidarity Trial Consortium.
– volume: 1
  start-page: 33
  year: 2021
  ident: 627_CR10
  publication-title: Nat. Comput. Sci.
  doi: 10.1038/s43588-020-00007-6
  contributor:
    fullname: G Galindez
– ident: 627_CR47
  doi: 10.1128/AAC.02428-20
– volume: 73
  start-page: 1
  year: 2019
  ident: 627_CR70
  publication-title: Am. Stat.
  doi: 10.1080/00031305.2019.1583913
  contributor:
    fullname: RL Wasserstein
– volume: 375
  start-page: n2422
  year: 2021
  ident: 627_CR51
  publication-title: BMJ
  doi: 10.1136/bmj.n2422
  contributor:
    fullname: E Mahase
– volume: 63
  start-page: 12256
  year: 2020
  ident: 627_CR36
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.0c00502
  contributor:
    fullname: S Xiu
– ident: 627_CR46
  doi: 10.1093/jac/dkab318
– volume: 367
  start-page: 982
  year: 2020
  ident: 627_CR21
  publication-title: Science
  doi: 10.1126/science.aaz3023
  contributor:
    fullname: D Ho
– volume: 141
  start-page: 40
  year: 2020
  ident: 627_CR41
  publication-title: Eur. J. Cancer
  doi: 10.1016/j.ejca.2020.09.014
  contributor:
    fullname: K El Bairi
– ident: 627_CR50
  doi: 10.1126/scitranslmed.abl7430
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Snippet IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies against...
Abstract IDentif.AI-x, a clinically actionable artificial intelligence platform, was used to rapidly pinpoint and prioritize optimal combination therapies...
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SubjectTerms 631/114
692/699/255/2514
Artificial intelligence
Biomedicine
Biotechnology
Combination therapy
Coronaviruses
COVID-19
Digital technology
Drug efficacy
Emergency preparedness
Medicine
Medicine & Public Health
Pandemics
Severe acute respiratory syndrome coronavirus 2
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Title The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens
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