Cyperotundone combined with adriamycin induces apoptosis in MCF-7 and MCF-7/ADR cancer cells by ROS generation and NRF2/ARE signaling pathway

• Published in: Scientific reports Vol. 13; no. 1; pp. 1384 - 12
• Main Authors: Shao, Wenna, Wang, Xinzhao, Liu, Zhaoyun, Song, Xiang, Wang, Fukai, Liu, Xiaoyu, Yu, Zhiyong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.01.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/1347; 631/80/82/23; Animals; Apoptosis; Breast cancer; Breast Neoplasms - pathology; Cell cycle; Chemotherapy; Cholecystokinin; Doxorubicin - pharmacology; Doxorubicin - therapeutic use; Drug Resistance, Neoplasm; Female; G1 phase; Humanities and Social Sciences; Humans; MCF-7 Cells; Mice; Mice, Nude; multidisciplinary; NF-E2-Related Factor 2 - metabolism; Oxidative stress; Reactive Oxygen Species - pharmacology; Science; Science (multidisciplinary); Signal Transduction

Breast cancer has become the most prevalent cancer, globally. Adriamycin is a first-line chemotherapeutic agent, however, cancer cells acquire resistance to it, which is one of the most common causes of treatment failure. ROS and NRF2 are essential oxidative stress factors that play a key role in th...