Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infectio...
Saved in:
| Published in | Scientific reports Vol. 7; no. 1; pp. 9110 - 12 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
Nature Publishing Group UK
22.08.2017
Nature Publishing Group Nature Portfolio |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments. |
|---|---|
| AbstractList | Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments. Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments. Abstract Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments. |
| ArticleNumber | 9110 |
| Author | Li, Yu Liu, Huiling Chen, Huaiyong Yan, Zhongfang Wu, Junping Li, Kuan Hu, Chunxiu Zhao, Jieyu Zhou, Lina Wu, Qi Xu, Long Zhang, Qiuyang Li, Xue Sun, Xin Wang, Xiaolin Yin, Peiyuan Li, Yanli Xu, Guowang |
| Author_xml | – sequence: 1 givenname: Qi surname: Wu fullname: Wu, Qi organization: Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University – sequence: 2 givenname: Lina surname: Zhou fullname: Zhou, Lina organization: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 3 givenname: Xin surname: Sun fullname: Sun, Xin organization: Department of Respiratory Medicine, Tianjin Haihe Hospital – sequence: 4 givenname: Zhongfang surname: Yan fullname: Yan, Zhongfang organization: Department of Nutrition, Tianjin Haihe Hospital – sequence: 5 givenname: Chunxiu surname: Hu fullname: Hu, Chunxiu organization: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 6 givenname: Junping surname: Wu fullname: Wu, Junping organization: Department of Respiratory Medicine, Tianjin Haihe Hospital – sequence: 7 givenname: Long surname: Xu fullname: Xu, Long organization: Department of Respiratory Medicine, Tianjin Haihe Hospital – sequence: 8 givenname: Xue surname: Li fullname: Li, Xue organization: Department of Basic Medicine, Tianjin Haihe Hospital – sequence: 9 givenname: Huiling surname: Liu fullname: Liu, Huiling organization: Department of Gastroenterology, Tianjin Haihe Hospital – sequence: 10 givenname: Peiyuan surname: Yin fullname: Yin, Peiyuan organization: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 11 givenname: Kuan surname: Li fullname: Li, Kuan organization: Department of Basic Medicine, Tianjin Haihe Hospital – sequence: 12 givenname: Jieyu surname: Zhao fullname: Zhao, Jieyu organization: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 13 givenname: Yanli surname: Li fullname: Li, Yanli organization: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 14 givenname: Xiaolin surname: Wang fullname: Wang, Xiaolin organization: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 15 givenname: Yu surname: Li fullname: Li, Yu organization: Department of Basic Medicine, Tianjin Haihe Hospital – sequence: 16 givenname: Qiuyang surname: Zhang fullname: Zhang, Qiuyang organization: Department of Basic Medicine, Tianjin Haihe Hospital – sequence: 17 givenname: Guowang orcidid: 0000-0003-4298-3554 surname: Xu fullname: Xu, Guowang email: xugw@dicp.ac.cn organization: CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences – sequence: 18 givenname: Huaiyong surname: Chen fullname: Chen, Huaiyong email: huaiyong.chen@foxmail.com organization: Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University, Department of Basic Medicine, Tianjin Haihe Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28831119$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Uk1vEzEUtFARLaV_gANaiQuXBdvrzwtSVEGJFETVlgMny_FHcLSxg70Jan89TrZUaSXwxZbfzHje87wERzFFB8BrBN8j2IkPhSAqRQsRb6GkHWvvnoETDAltcYfx0cH5GJyVsoR1USwJki_AMRaiQwjJE3A56QeXnW1mYR1s89UNep76UFZNiM2VM2m7r15Prq6bSz0EF4fS3Px2_dY1P5zOpdG-CjTT6J0ZQoqvwHOv--LO7vdT8P3zp5vzL-3s28X0fDJrDSVwaJnhc-uZsAQyBKUk2nuvieC1F4slIgJJw6CG1AiJMKWus0x7LC03iHLZnYLpqGuTXqp1Diudb1XSQe0vUl4onYdgeqfI3NQRQSwY1kR3WgqPGLVSUOaJ4aJqfRy11pv5yllTm8y6fyT6uBLDT7VIW0Up4xjuzLy7F8jp18aVQa1CMa7vdXRpUxSSHeIIsg5V6Nsn0GXa5FhHVVGUY0b5XvDNoaMHK38_rgLwCDA5lZKdf4AgqHYBUWNAVA2I2gdE3VWSeEIyYdC7X6tdhf7_1G6klvpOXLh8YPvfrD_1Es3c |
| CitedBy_id | crossref_primary_10_1016_j_regg_2021_10_003 crossref_primary_10_1017_cjn_2023_39 crossref_primary_10_1016_j_bcp_2020_114114 crossref_primary_10_5501_wjv_v11_i5_237 crossref_primary_10_1016_j_mehy_2020_109759 crossref_primary_10_3389_fmicb_2021_723818 crossref_primary_10_1097_CRD_0000000000000552 crossref_primary_10_7762_cnr_2022_11_4_331 crossref_primary_10_1177_2047487320925965 crossref_primary_10_3389_fgene_2020_586308 crossref_primary_10_1016_j_heliyon_2022_e10473 crossref_primary_10_1097_CRD_0000000000000317 crossref_primary_10_3390_ijerph22020166 crossref_primary_10_1016_j_metabol_2022_155267 crossref_primary_10_1016_j_rccar_2020_04_006 crossref_primary_10_3934_mbe_2022270 crossref_primary_10_52711_2231_5713_2024_00014 crossref_primary_10_1007_s12020_023_03611_4 crossref_primary_10_1371_journal_pone_0278057 crossref_primary_10_3389_fphar_2022_890141 crossref_primary_10_1111_jocs_14538 crossref_primary_10_1038_s41598_023_43189_5 crossref_primary_10_1152_ajpheart_00204_2022 crossref_primary_10_1038_s41392_020_0191_1 crossref_primary_10_1016_j_resmer_2022_100904 crossref_primary_10_1016_j_clnesp_2021_06_011 crossref_primary_10_1080_13696998_2022_2030148 crossref_primary_10_32322_jhsm_1152747 crossref_primary_10_1152_ajpendo_00255_2020 crossref_primary_10_3389_fpubh_2021_628333 crossref_primary_10_26442_26586630_2022_3_201814 crossref_primary_10_3390_vaccines11121746 crossref_primary_10_34133_2020_2402961 crossref_primary_10_3389_fcvm_2020_599334 crossref_primary_10_3390_ijms21103544 crossref_primary_10_3389_fmolb_2023_1100486 crossref_primary_10_1128_msystems_00726_23 crossref_primary_10_1155_2024_3248305 crossref_primary_10_18093_0869_0189_2021_31_5_562_570 crossref_primary_10_3389_fimmu_2024_1320779 crossref_primary_10_1161_ATVBAHA_120_314558 crossref_primary_10_3390_epidemiologia2010011 crossref_primary_10_3390_ijms22115980 crossref_primary_10_1007_s43440_023_00517_w crossref_primary_10_3390_biom13010163 crossref_primary_10_3389_fimmu_2024_1363572 crossref_primary_10_3389_fimmu_2022_945016 crossref_primary_10_1016_j_metabol_2020_154245 crossref_primary_10_2147_JIR_S325853 crossref_primary_10_3201_eid2905_221349 crossref_primary_10_1055_a_1751_9442 crossref_primary_10_2196_45225 crossref_primary_10_1016_j_dsx_2020_06_049 crossref_primary_10_2144_fsoa_2020_0207 crossref_primary_10_1002_ajhb_23482 crossref_primary_10_1055_a_1878_9307 crossref_primary_10_2147_JIR_S355568 crossref_primary_10_33667_2078_5631_2023_26_7_12 crossref_primary_10_4103_ijpvm_IJPVM_628_20 crossref_primary_10_1016_j_apsb_2022_02_019 crossref_primary_10_34883_PI_2020_12_3_006 crossref_primary_10_1002_jcp_30109 crossref_primary_10_1016_j_medcle_2020_04_012 crossref_primary_10_1080_22221751_2020_1825914 crossref_primary_10_1007_s11033_022_08087_5 crossref_primary_10_1016_j_medcli_2020_04_015 crossref_primary_10_3389_fphys_2023_1036925 crossref_primary_10_1111_all_14449 crossref_primary_10_2196_24211 crossref_primary_10_1177_15353702221128563 crossref_primary_10_1371_journal_pone_0255263 crossref_primary_10_1038_s41419_022_04674_3 crossref_primary_10_1021_acs_jproteome_1c00224 crossref_primary_10_1038_s41591_021_01283_z crossref_primary_10_1152_physiolgenomics_00087_2020 crossref_primary_10_1016_j_idnow_2023_104779 crossref_primary_10_1186_s12931_020_01390_4 crossref_primary_10_1161_JAHA_123_031338 crossref_primary_10_3390_covid3040037 crossref_primary_10_3389_fimmu_2021_686240 crossref_primary_10_1016_j_medcli_2021_09_014 crossref_primary_10_3389_fimmu_2022_890517 crossref_primary_10_1016_j_trac_2021_116198 crossref_primary_10_3389_fmed_2020_629413 crossref_primary_10_2174_1874467213666201204154239 crossref_primary_10_1097_NNR_0000000000000565 crossref_primary_10_1021_acs_analchem_1c04576 crossref_primary_10_1016_j_asoc_2024_112407 crossref_primary_10_1128_cmr_00188_21 crossref_primary_10_1016_j_mayocp_2021_12_017 crossref_primary_10_1039_D3NA00190C crossref_primary_10_1021_acsomega_4c02557 crossref_primary_10_31083_j_rcm_2020_04_236 crossref_primary_10_1016_j_biopha_2023_115493 crossref_primary_10_3389_fimmu_2023_1085610 crossref_primary_10_1007_s10565_024_09976_0 crossref_primary_10_1371_journal_pone_0287430 crossref_primary_10_1161_CIRCRESAHA_120_317055 crossref_primary_10_12998_wjcc_v9_i1_1 crossref_primary_10_1016_j_pharmthera_2020_107703 crossref_primary_10_52340_jecm_2022_02_18 crossref_primary_10_1016_j_virol_2024_110198 crossref_primary_10_7554_eLife_79946 crossref_primary_10_1016_j_yjmcc_2020_04_031 crossref_primary_10_1017_dmp_2021_154 crossref_primary_10_4103_cjhr_cjhr_57_22 crossref_primary_10_1016_j_talanta_2023_125522 crossref_primary_10_1055_a_1269_1405 crossref_primary_10_15829_1560_4071_2021_4358 crossref_primary_10_2174_2666796704666230608121558 crossref_primary_10_3389_fmed_2021_585851 crossref_primary_10_56083_RCV5N2_102 crossref_primary_10_1016_j_eclinm_2023_101884 crossref_primary_10_1016_j_isci_2023_107799 crossref_primary_10_3390_metabo12070641 crossref_primary_10_3389_fphar_2020_621099 crossref_primary_10_1016_j_hrtlng_2021_01_016 crossref_primary_10_4103_jrms_jrms_552_21 crossref_primary_10_1136_jim_2020_001592 crossref_primary_10_1093_cvr_cvaa086 crossref_primary_10_3390_rel13090780 crossref_primary_10_1055_a_1172_1352 crossref_primary_10_2174_2211738508999200817163335 crossref_primary_10_25000_acem_1072942 crossref_primary_10_3390_metabo13070879 crossref_primary_10_1007_s12035_020_02236_2 crossref_primary_10_1016_j_cpcardiol_2021_100907 crossref_primary_10_21518_2079_701X_2022_16_18_141_146 crossref_primary_10_3390_ijms21228623 crossref_primary_10_1007_s11940_023_00747_6 crossref_primary_10_1002_mds3_10140 crossref_primary_10_1177_10547738231177481 crossref_primary_10_1515_jbcpp_2022_0057 crossref_primary_10_1016_j_medcle_2021_09_030 crossref_primary_10_1111_joim_13070 crossref_primary_10_1080_10498850_2024_2351531 crossref_primary_10_1016_j_numecd_2021_06_016 crossref_primary_10_1186_s12879_021_05984_1 crossref_primary_10_3389_fgene_2022_1041342 crossref_primary_10_1080_14787210_2021_1893692 crossref_primary_10_1021_acs_analchem_0c04679 crossref_primary_10_1136_postgradmedj_2020_139585 crossref_primary_10_25207_1608_6228_2021_28_6_90_116 crossref_primary_10_3390_epigenomes6020013 crossref_primary_10_1007_s11547_020_01311_x crossref_primary_10_1007_s11883_021_00935_2 crossref_primary_10_1055_a_1878_9757 crossref_primary_10_3389_fcvm_2021_649922 crossref_primary_10_3389_fendo_2021_611526 crossref_primary_10_47320_rasbran_2021_2354 crossref_primary_10_18087_cardio_2020_11_n1398 crossref_primary_10_1038_s41366_020_00689_y crossref_primary_10_3389_fpubh_2022_903568 crossref_primary_10_1016_j_biopha_2021_111267 crossref_primary_10_32322_jhsm_1027661 crossref_primary_10_1007_s42399_020_00391_0 crossref_primary_10_1136_bmj_n1098 crossref_primary_10_4103_hm_hm_28_20 crossref_primary_10_1124_molpharm_120_000119 crossref_primary_10_1186_s12967_019_1898_z crossref_primary_10_25298_2221_8785_2021_19_1_5_9 crossref_primary_10_3904_kjm_2022_97_1_23 crossref_primary_10_1186_s10020_024_00855_2 crossref_primary_10_17816_brmma346692 crossref_primary_10_1007_s11033_021_06148_9 crossref_primary_10_1016_j_jtumed_2021_01_006 crossref_primary_10_1097_HCO_0000000000000851 crossref_primary_10_1038_s41598_023_41523_5 crossref_primary_10_17116_profmed20232604143 crossref_primary_10_1007_s10554_021_02171_w crossref_primary_10_1093_cvr_cvac115 crossref_primary_10_4103_tcmj_tcmj_219_22 crossref_primary_10_1097_CD9_0000000000000038 crossref_primary_10_1177_14782715221124617 crossref_primary_10_1016_j_jacl_2020_04_008 crossref_primary_10_1016_j_athplu_2021_08_001 crossref_primary_10_1016_j_jlr_2021_100129 crossref_primary_10_2147_JPR_S269206 crossref_primary_10_1136_jclinpath_2020_206834 crossref_primary_10_1007_s00430_021_00727_0 crossref_primary_10_3390_jcm11030524 crossref_primary_10_1016_j_recesp_2020_08_009 crossref_primary_10_1016_j_amjms_2020_05_006 crossref_primary_10_1016_j_lfs_2020_118496 crossref_primary_10_1038_s41419_024_06642_5 crossref_primary_10_3390_medicina59122065 crossref_primary_10_3389_fmed_2021_653773 crossref_primary_10_1016_j_dsx_2020_03_013 crossref_primary_10_21320_1818_474X_2021_S1_9_143 crossref_primary_10_3390_metabo11070467 crossref_primary_10_3389_fimmu_2021_686029 crossref_primary_10_1016_j_mjafi_2020_05_004 crossref_primary_10_1016_j_cmet_2022_04_008 crossref_primary_10_3389_fpsyt_2021_782478 crossref_primary_10_1097_HCO_0000000000000838 crossref_primary_10_1007_s12016_021_08848_3 crossref_primary_10_3390_ijms222212243 crossref_primary_10_1177_15910199211035920 crossref_primary_10_1038_s41419_023_05791_3 crossref_primary_10_1016_j_pharmthera_2020_107750 crossref_primary_10_1007_s13721_020_00276_1 crossref_primary_10_1016_j_bios_2023_115152 crossref_primary_10_4103_ijrc_ijrc_100_20 crossref_primary_10_4103_2773_0387_348713 crossref_primary_10_3389_fimmu_2022_868679 crossref_primary_10_3389_fmicb_2022_863802 crossref_primary_10_1007_s11883_022_01032_8 crossref_primary_10_1016_j_ebiom_2021_103722 crossref_primary_10_15829_1560_4071_2022_5042 crossref_primary_10_1007_s42399_021_00874_8 crossref_primary_10_1210_endrev_bnad032 crossref_primary_10_1038_s41569_020_0360_5 crossref_primary_10_3389_fphar_2020_00836 crossref_primary_10_1055_s_0042_1755205 crossref_primary_10_1080_10408363_2020_1860895 crossref_primary_10_4103_ijp_ijp_442_21 crossref_primary_10_1186_s12889_021_11715_7 crossref_primary_10_1177_0363546520975186 crossref_primary_10_3390_pathogens9070546 crossref_primary_10_3748_wjg_v26_i48_7693 crossref_primary_10_1021_acs_jproteome_0c00519 crossref_primary_10_1007_s12016_022_08925_1 crossref_primary_10_1186_s10020_022_00465_w crossref_primary_10_1093_eurheartj_ehaa231 crossref_primary_10_1002_cti2_1343 crossref_primary_10_3389_fpubh_2021_620060 crossref_primary_10_1016_j_rec_2020_08_027 crossref_primary_10_1007_s11886_020_01434_7 crossref_primary_10_3390_genes12060796 crossref_primary_10_2147_DMSO_S285614 crossref_primary_10_1002_aesr_202400195 crossref_primary_10_1016_j_cjca_2023_01_031 crossref_primary_10_34067_KID_0001632022 crossref_primary_10_1021_acs_analchem_1c05389 crossref_primary_10_1002_erv_2770 crossref_primary_10_3390_metabo12080713 crossref_primary_10_21320_1818_474X_2020_S1_9_120 crossref_primary_10_1186_s12985_022_01867_2 crossref_primary_10_3389_fendo_2022_780663 crossref_primary_10_7759_cureus_52827 crossref_primary_10_1002_nbm_4637 crossref_primary_10_1016_j_clnesp_2021_07_023 crossref_primary_10_1089_hs_2020_0121 crossref_primary_10_1007_s10557_023_07465_w crossref_primary_10_1016_j_hlc_2020_05_004 crossref_primary_10_3390_ijerph192013280 crossref_primary_10_4103_ijmr_IJMR_977_20 crossref_primary_10_1007_s40495_020_00239_0 crossref_primary_10_1155_2021_7394378 crossref_primary_10_1016_j_crimmu_2022_08_006 crossref_primary_10_1002_rmv_2356 crossref_primary_10_1186_s12944_021_01563_0 crossref_primary_10_1016_j_isci_2020_101645 crossref_primary_10_15829_1728_8800_2022_3235 crossref_primary_10_3389_fphys_2021_624698 crossref_primary_10_3390_jcm9113746 crossref_primary_10_1021_acs_jproteome_1c00052 crossref_primary_10_1007_s11154_022_09715_y crossref_primary_10_21320_1818_474X_2022_1_5_140 crossref_primary_10_15829_1728_8800_2020_2630 crossref_primary_10_2174_2666796701999200701132336 crossref_primary_10_1161_CIRCULATIONAHA_120_047549 crossref_primary_10_3389_fmed_2020_595503 crossref_primary_10_3389_fcvm_2020_00140 |
| Cites_doi | 10.1016/j.mce.2013.12.011 10.1016/S0006-291X(86)80556-3 10.1074/jbc.M111.312561 10.3390/v7030996 10.1038/nm1024 10.1016/j.virol.2004.08.011 10.1080/00313020600696231 10.1186/1752-0509-6-139 10.1038/srep19125 10.1038/nature12711 10.1073/pnas.0711278105 10.1016/j.jinf.2006.01.005 10.1086/386340 10.1038/nm.3985 10.1073/pnas.1517719113 10.1194/jlr.M055723 10.1148/radiol.2351040100 10.1056/NEJMoa030666 10.1128/JVI.79.2.884-895.2005 10.1016/j.coph.2012.09.009 10.1007/s11306-015-0889-1 10.1073/pnas.1119155109 10.1530/JOE-11-0166 10.1111/j.1476-5381.2010.00743.x 10.1007/s10096-004-1271-9 10.1128/JVI.72.3.1775-1781.1998 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2017 Scientific Reports is a copyright of Springer, 2017. |
| Copyright_xml | – notice: The Author(s) 2017 – notice: Scientific Reports is a copyright of Springer, 2017. |
| DBID | C6C AAYXX CITATION NPM 3V. 7X7 7XB 88A 88E 88I 8FE 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BBNVY BENPR BHPHI CCPQU COVID DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 5PM DOA |
| DOI | 10.1038/s41598-017-09536-z |
| DatabaseName | Springer Nature OA Free Journals CrossRef PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College Coronavirus Research Database ProQuest Central Korea Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database CrossRef MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: C6C name: Springer Nature OA Free Journals url: http://www.springeropen.com/ sourceTypes: Publisher – sequence: 2 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 3 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2045-2322 |
| EndPage | 12 |
| ExternalDocumentID | oai_doaj_org_article_4bc09502862a4a3a98f165d9856f4c78 PMC5567209 28831119 10_1038_s41598_017_09536_z |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | 0R~ 3V. 4.4 53G 5VS 7X7 88A 88E 88I 8FE 8FH 8FI 8FJ AAFWJ AAJSJ AAKDD ABDBF ABUWG ACGFS ACSMW ACUHS ADBBV ADRAZ AENEX AEUYN AFKRA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BBNVY BCNDV BENPR BHPHI BPHCQ BVXVI C6C CCPQU DIK DWQXO EBD EBLON EBS EJD ESX FYUFA GNUQQ GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE KQ8 LK8 M0L M1P M2P M48 M7P M~E NAO OK1 PIMPY PQQKQ PROAC PSQYO RNT RNTTT RPM SNYQT UKHRP AASML AAYXX AFPKN CITATION PHGZM PHGZT NPM 7XB 8FK AARCD COVID K9. PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U 7X8 5PM PUEGO |
| ID | FETCH-LOGICAL-c540t-6c7bdf68d40610994afffa487953d2914819c60a05c891255e3d6af29d7c15793 |
| IEDL.DBID | 7X7 |
| ISSN | 2045-2322 |
| IngestDate | Wed Aug 27 01:28:07 EDT 2025 Thu Aug 21 18:10:53 EDT 2025 Mon Jul 21 11:24:10 EDT 2025 Wed Aug 13 04:08:42 EDT 2025 Thu Apr 03 06:56:58 EDT 2025 Tue Jul 01 02:40:50 EDT 2025 Thu Apr 24 23:01:26 EDT 2025 Fri Feb 21 02:40:02 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c540t-6c7bdf68d40610994afffa487953d2914819c60a05c891255e3d6af29d7c15793 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0003-4298-3554 |
| OpenAccessLink | https://www.proquest.com/docview/1957265709?pq-origsite=%requestingapplication% |
| PMID | 28831119 |
| PQID | 1957265709 |
| PQPubID | 2041939 |
| PageCount | 12 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_4bc09502862a4a3a98f165d9856f4c78 pubmedcentral_primary_oai_pubmedcentral_nih_gov_5567209 proquest_miscellaneous_1931710631 proquest_journals_1957265709 pubmed_primary_28831119 crossref_primary_10_1038_s41598_017_09536_z crossref_citationtrail_10_1038_s41598_017_09536_z springer_journals_10_1038_s41598_017_09536_z |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2017-08-22 |
| PublicationDateYYYYMMDD | 2017-08-22 |
| PublicationDate_xml | – month: 08 year: 2017 text: 2017-08-22 day: 22 |
| PublicationDecade | 2010 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Scientific reports |
| PublicationTitleAbbrev | Sci Rep |
| PublicationTitleAlternate | Sci Rep |
| PublicationYear | 2017 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Menachery (CR4) 2015; 21 Jia (CR11) 2009; 29 Ford (CR28) 2010; 160 Menachery (CR5) 2016; 113 Numata (CR21) 2015; 56 Berry, Gamieldien, Fielding (CR3) 2015; 7 Lauckner (CR26) 2008; 105 Woo (CR2) 2005; 79 Yam (CR12) 2007; 54 Li, Sun, Wu, Xing, Yu (CR19) 2015; 38 Xu, Jiang, Chen, Fang (CR13) 2008; 20 Rohn (CR30) 2012; 6 Johnson, Taghon, Scott, Stahelin (CR18) 2016; 6 Chen, Cao (CR8) 2004; 38 Yang (CR20) 2012; 287 Lam, Chan, Wong (CR14) 2004; 25 Griffith (CR16) 2005; 235 Tsang (CR7) 2003; 348 Cheng (CR10) 2005; 24 Ruiz-Arguello, Goni, Pereira, Nieva (CR17) 1998; 72 Overgaard (CR25) 2016; 12 Sainz, Mossel, Peters, Garry (CR9) 2004; 329 van der Hoek (CR1) 2004; 10 Wu (CR29) 2012; 109 Schicho, Storr (CR27) 2012; 12 Romero-Zerbo (CR24) 2011; 211 Metz (CR23) 1986; 138 Imbernon (CR22) 2014; 383 Ge (CR6) 2013; 503 Chan (CR15) 2006; 38 R Schicho (9536_CR27) 2012; 12 XY Ge (9536_CR6) 2013; 503 R Wu (9536_CR29) 2012; 109 L van der Hoek (9536_CR1) 2004; 10 WD Jia (9536_CR11) 2009; 29 M Imbernon (9536_CR22) 2014; 383 LA Ford (9536_CR28) 2010; 160 AJ Overgaard (9536_CR25) 2016; 12 JE Lauckner (9536_CR26) 2008; 105 XP Chen (9536_CR8) 2004; 38 MH Chan (9536_CR15) 2006; 38 L Li (9536_CR19) 2015; 38 Y Cheng (9536_CR10) 2005; 24 SA Metz (9536_CR23) 1986; 138 YD Xu (9536_CR13) 2008; 20 M Berry (9536_CR3) 2015; 7 VD Menachery (9536_CR5) 2016; 113 KA Johnson (9536_CR18) 2016; 6 LY Yam (9536_CR12) 2007; 54 JF Griffith (9536_CR16) 2005; 235 PC Woo (9536_CR2) 2005; 79 M Numata (9536_CR21) 2015; 56 CW Lam (9536_CR14) 2004; 25 MB Ruiz-Arguello (9536_CR17) 1998; 72 KW Tsang (9536_CR7) 2003; 348 N Yang (9536_CR20) 2012; 287 SY Romero-Zerbo (9536_CR24) 2011; 211 B Sainz Jr. (9536_CR9) 2004; 329 VD Menachery (9536_CR4) 2015; 21 H Rohn (9536_CR30) 2012; 6 |
| References_xml | – volume: 383 start-page: 159 year: 2014 end-page: 169 ident: CR22 article-title: Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors publication-title: Molecular and cellular endocrinology doi: 10.1016/j.mce.2013.12.011 – volume: 138 start-page: 720 year: 1986 end-page: 727 ident: CR23 article-title: Lysophosphatidylinositol, but not lysophosphatidic acid, stimulates insulin release. A possible role for phospholipase A2 but not de novo synthesis of lysophospholipid in pancreatic islet function publication-title: Biochemical and biophysical research communications doi: 10.1016/S0006-291X(86)80556-3 – volume: 287 start-page: 8457 year: 2012 end-page: 8467 ident: CR20 article-title: Phosphatidylinositol 4-kinase IIIbeta is required for severe acute respiratory syndrome coronavirus spike-mediated cell entry publication-title: The Journal of biological chemistry doi: 10.1074/jbc.M111.312561 – volume: 7 start-page: 996 year: 2015 end-page: 1019 ident: CR3 article-title: Identification of new respiratory viruses in the new millennium publication-title: Viruses doi: 10.3390/v7030996 – volume: 10 start-page: 368 year: 2004 end-page: 373 ident: CR1 article-title: Identification of a new human coronavirus publication-title: Nature medicine doi: 10.1038/nm1024 – volume: 329 start-page: 11 year: 2004 end-page: 17 ident: CR9 article-title: Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) publication-title: Virology doi: 10.1016/j.virol.2004.08.011 – volume: 29 start-page: 2284 year: 2009 end-page: 2287 ident: CR11 article-title: [Dose of glucocorticosteroids in the treatment of severe acute respiratory syndrome] publication-title: Nan fang yi ke da xue xue bao=Journal of Southern Medical University – volume: 38 start-page: 575 year: 2015 end-page: 578 ident: CR19 article-title: [The lung function status in patients with severe acute respiratory syndrome after ten years of convalescence in Tianjin] publication-title: Zhonghua Jie He He Hu Xi Za Zhi – volume: 38 start-page: 229 year: 2006 end-page: 235 ident: CR15 article-title: Steroid-induced osteonecrosis in severe acute respiratory syndrome: a retrospective analysis of biochemical markers of bone metabolism and corticosteroid therapy publication-title: Pathology doi: 10.1080/00313020600696231 – volume: 20 start-page: 84 year: 2008 end-page: 87 ident: CR13 article-title: [Evaluation of the efficacy and safety of corticosteroid in the treatment of severe SARS in Guangdong province with multi-factor regression analysis] publication-title: Zhongguo wei zhong bing ji jiu yi xue=Chinese critical care medicine=Zhongguo weizhongbing jijiuyixue – volume: 6 year: 2012 ident: CR30 article-title: VANTED v2: a framework for systems biology applications publication-title: BMC systems biology doi: 10.1186/1752-0509-6-139 – volume: 6 year: 2016 ident: CR18 article-title: The Ebola Virus matrix protein, VP40, requires phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) for extensive oligomerization at the plasma membrane and viral egress publication-title: Scientific reports doi: 10.1038/srep19125 – volume: 503 start-page: 535 year: 2013 end-page: 538 ident: CR6 article-title: Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor publication-title: Nature doi: 10.1038/nature12711 – volume: 105 start-page: 2699 year: 2008 end-page: 2704 ident: CR26 article-title: GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.0711278105 – volume: 54 start-page: 28 year: 2007 end-page: 39 ident: CR12 article-title: Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong publication-title: The Journal of infection doi: 10.1016/j.jinf.2006.01.005 – volume: 38 start-page: 1030 year: 2004 end-page: 1032 ident: CR8 article-title: Consideration of highly active antiretroviral therapy in the prevention and treatment of severe acute respiratory syndrome publication-title: Clinical infectious diseases: an official publication of the Infectious Diseases Society of America doi: 10.1086/386340 – volume: 21 start-page: 1508 year: 2015 end-page: 1513 ident: CR4 article-title: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence publication-title: Nature medicine doi: 10.1038/nm.3985 – volume: 72 start-page: 1775 year: 1998 end-page: 1781 ident: CR17 article-title: Phosphatidylinositol-dependent membrane fusion induced by a putative fusogenic sequence of Ebola virus publication-title: Journal of virology – volume: 113 start-page: 3048 year: 2016 end-page: 3053 ident: CR5 article-title: SARS-like WIV1-CoV poised for human emergence publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1517719113 – volume: 56 start-page: 578 year: 2015 end-page: 587 ident: CR21 article-title: Phosphatidylinositol inhibits respiratory syncytial virus infection publication-title: Journal of lipid research doi: 10.1194/jlr.M055723 – volume: 235 start-page: 168 year: 2005 end-page: 175 ident: CR16 article-title: Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids publication-title: Radiology doi: 10.1148/radiol.2351040100 – volume: 348 start-page: 1977 year: 2003 end-page: 1985 ident: CR7 article-title: A cluster of cases of severe acute respiratory syndrome in Hong Kong publication-title: The New England journal of medicine doi: 10.1056/NEJMoa030666 – volume: 79 start-page: 884 year: 2005 end-page: 895 ident: CR2 article-title: Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia publication-title: Journal of virology doi: 10.1128/JVI.79.2.884-895.2005 – volume: 25 start-page: 121 year: 2004 end-page: 132 ident: CR14 article-title: Severe acute respiratory syndrome: clinical and laboratory manifestations. publication-title: Reviews/Australian Association of Clinical Biochemists – volume: 12 start-page: 653 year: 2012 end-page: 658 ident: CR27 article-title: A potential role for GPR55 in gastrointestinal functions publication-title: Current opinion in pharmacology doi: 10.1016/j.coph.2012.09.009 – volume: 12 year: 2016 ident: CR25 article-title: Lipidomic and metabolomic characterization of a genetically modified mouse model of the early stages of human type 1 diabetes pathogenesis publication-title: Metabolomics: Official journal of the Metabolomic Society doi: 10.1007/s11306-015-0889-1 – volume: 109 start-page: 3259 year: 2012 end-page: 3263 ident: CR29 article-title: Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1119155109 – volume: 211 start-page: 177 year: 2011 end-page: 185 ident: CR24 article-title: A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans publication-title: The Journal of endocrinology doi: 10.1530/JOE-11-0166 – volume: 160 start-page: 762 year: 2010 end-page: 771 ident: CR28 article-title: A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells publication-title: British journal of pharmacology doi: 10.1111/j.1476-5381.2010.00743.x – volume: 24 start-page: 44 year: 2005 end-page: 46 ident: CR10 article-title: Use of convalescent plasma therapy in SARS patients in Hong Kong publication-title: European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology doi: 10.1007/s10096-004-1271-9 – volume: 109 start-page: 3259 year: 2012 ident: 9536_CR29 publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1119155109 – volume: 20 start-page: 84 year: 2008 ident: 9536_CR13 publication-title: Zhongguo wei zhong bing ji jiu yi xue=Chinese critical care medicine=Zhongguo weizhongbing jijiuyixue – volume: 6 year: 2012 ident: 9536_CR30 publication-title: BMC systems biology doi: 10.1186/1752-0509-6-139 – volume: 56 start-page: 578 year: 2015 ident: 9536_CR21 publication-title: Journal of lipid research doi: 10.1194/jlr.M055723 – volume: 12 start-page: 653 year: 2012 ident: 9536_CR27 publication-title: Current opinion in pharmacology doi: 10.1016/j.coph.2012.09.009 – volume: 348 start-page: 1977 year: 2003 ident: 9536_CR7 publication-title: The New England journal of medicine doi: 10.1056/NEJMoa030666 – volume: 12 year: 2016 ident: 9536_CR25 publication-title: Metabolomics: Official journal of the Metabolomic Society doi: 10.1007/s11306-015-0889-1 – volume: 29 start-page: 2284 year: 2009 ident: 9536_CR11 publication-title: Nan fang yi ke da xue xue bao=Journal of Southern Medical University – volume: 54 start-page: 28 year: 2007 ident: 9536_CR12 publication-title: The Journal of infection doi: 10.1016/j.jinf.2006.01.005 – volume: 6 year: 2016 ident: 9536_CR18 publication-title: Scientific reports doi: 10.1038/srep19125 – volume: 38 start-page: 229 year: 2006 ident: 9536_CR15 publication-title: Pathology doi: 10.1080/00313020600696231 – volume: 105 start-page: 2699 year: 2008 ident: 9536_CR26 publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.0711278105 – volume: 10 start-page: 368 year: 2004 ident: 9536_CR1 publication-title: Nature medicine doi: 10.1038/nm1024 – volume: 21 start-page: 1508 year: 2015 ident: 9536_CR4 publication-title: Nature medicine doi: 10.1038/nm.3985 – volume: 383 start-page: 159 year: 2014 ident: 9536_CR22 publication-title: Molecular and cellular endocrinology doi: 10.1016/j.mce.2013.12.011 – volume: 7 start-page: 996 year: 2015 ident: 9536_CR3 publication-title: Viruses doi: 10.3390/v7030996 – volume: 79 start-page: 884 year: 2005 ident: 9536_CR2 publication-title: Journal of virology doi: 10.1128/JVI.79.2.884-895.2005 – volume: 38 start-page: 1030 year: 2004 ident: 9536_CR8 publication-title: Clinical infectious diseases: an official publication of the Infectious Diseases Society of America doi: 10.1086/386340 – volume: 160 start-page: 762 year: 2010 ident: 9536_CR28 publication-title: British journal of pharmacology doi: 10.1111/j.1476-5381.2010.00743.x – volume: 25 start-page: 121 year: 2004 ident: 9536_CR14 publication-title: Reviews/Australian Association of Clinical Biochemists – volume: 329 start-page: 11 year: 2004 ident: 9536_CR9 publication-title: Virology doi: 10.1016/j.virol.2004.08.011 – volume: 235 start-page: 168 year: 2005 ident: 9536_CR16 publication-title: Radiology doi: 10.1148/radiol.2351040100 – volume: 72 start-page: 1775 year: 1998 ident: 9536_CR17 publication-title: Journal of virology doi: 10.1128/JVI.72.3.1775-1781.1998 – volume: 503 start-page: 535 year: 2013 ident: 9536_CR6 publication-title: Nature doi: 10.1038/nature12711 – volume: 287 start-page: 8457 year: 2012 ident: 9536_CR20 publication-title: The Journal of biological chemistry doi: 10.1074/jbc.M111.312561 – volume: 24 start-page: 44 year: 2005 ident: 9536_CR10 publication-title: European journal of clinical microbiology & infectious diseases: official publication of the European Society of Clinical Microbiology doi: 10.1007/s10096-004-1271-9 – volume: 113 start-page: 3048 year: 2016 ident: 9536_CR5 publication-title: Proceedings of the National Academy of Sciences of the United States of America doi: 10.1073/pnas.1517719113 – volume: 38 start-page: 575 year: 2015 ident: 9536_CR19 publication-title: Zhonghua Jie He He Hu Xi Za Zhi – volume: 211 start-page: 177 year: 2011 ident: 9536_CR24 publication-title: The Journal of endocrinology doi: 10.1530/JOE-11-0166 – volume: 138 start-page: 720 year: 1986 ident: 9536_CR23 publication-title: Biochemical and biophysical research communications doi: 10.1016/S0006-291X(86)80556-3 |
| SSID | ssj0000529419 |
| Score | 2.6311574 |
| Snippet | Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term... Abstract Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 9110 |
| SubjectTerms | 692/699/1785/3193 692/699/255/2514 Coronaviridae Coronaviruses COVID-19 Global health Glucose metabolism Humanities and Social Sciences Lipid metabolism Long-term effects Lung diseases Metabolism Metabolomics Methylprednisolone multidisciplinary Phosphatidylinositol Science Science (multidisciplinary) Severe acute respiratory syndrome Tumors |
| SummonAdditionalLinks | – databaseName: DOAJ Directory of Open Access Journals dbid: DOA link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3daxQxEA9SEHwRv12tEsE3XbrJ5vPxFEsVlGJbqE8hm2Tx4LoV91qxf70zyd5x5-eLr5uEHeYjM8NMfkPIcxaVRVypWkQua5EaXXcxNLUJTBrwKV6n3CD7QR2ciHen8nRj1Bf2hBV44MK4PdEFiALACyruhW-9NT1TMlojVS-Czs98wedtJFMF1Ztbwez0SqZpzd4Ingpfk8GljBBrqr7a8kQZsP93UeavzZI_VUyzI9q_RW5OESSdFcpvk2tpuEOul5mS3--SwxnWv1OkOJU60vdpCWJezMczOh8oJpuXefVo9vGIHhZQ1ZEef0uLy0Q_gdqPNI8Np2-nLq3hHjnZf3P8-qCexibUAcKvZa2C7mKvTERfDQGg8H3fe4FTxdvILeQ_zAbV-EYGYyG-kamNyvfcRg0CAnu9T3aG8yE9JNQH0_Waxxg6K6RNlrMOMsBWIlAg17EibMVCFyZMcRxtsXC5tt0aV9jugO0us91dVeTF-syXgqjx192vUDLrnYiGnT-AjrhJR9y_dKQiuyu5uslER8es1Bwbf2xFnq2XwbiwYuKHdH6BeyC8gqS5ZRV5UNRgTQmOaQZHAaf1loJskbq9Msw_ZwBvKZXm-N-XK1XaIOuPrHj0P1jxmNzg2QbgfuS7ZGf59SI9gbBq2T3NFvQD0KgaDA priority: 102 providerName: Directory of Open Access Journals – databaseName: Scholars Portal Journals: Open Access dbid: M48 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Nb9QwELVKERIXxDeBgozEDQIbx58HhBZEVZCKKtqVyslybKestGRhsy20v54ZJ1mxsPQa24oznsm8ke33CHlWBGmQVyrngYmcx5HKq-BHufaF0JBTnIrpgOwnuTfhH4_F8RYZ5I56A7YbSzvUk5osZi9__Th_AwH_ursyrl-1kITwohj8b5E9TeYXV8hVyEwKFQ32e7jfcX0zwwvT353ZPHQtPyUa_03Y898jlH_to6b0tHuT3OhxJR13jnCLbMXmNrnWKU2e3yEHY9wVj4GiVnWg-3EJiz-btt_otKFYgp6l1sPx50N60FGttvToZ5ydRfoFgqGlSUycfujPbjV3yWT3_dG7vbwXU8g9gLJlLr2qQi11wAwOsJC7uq4dR63xMjADVVFhvBy5kfDaAOoRsQzS1cwEBcsGUXyPbDfzJj4g1Hld1YqF4CvDhYmGFRXUhaVA-kCmQkaKwYTW90zjKHgxs2nHu9S2M7sFs9tkdnuRkeerMd87no1Le7_FlVn1RI7s9GC-OLF9yFleeegO-Ekyx13pjK4LKYLRQtbcK52RnWFd7eB3tjBCMTwOZDLydNUMIYf7KK6J81PsA6ALSumyyMj9zg1WM0HxZkgfMFqtOcjaVNdbmunXROsthFQM3_ticKU_pvVfUzy8_CsekesseTf8D9kO2V4uTuNjgFHL6kmKjd-C-BX7 priority: 102 providerName: Scholars Portal – databaseName: Springer Nature HAS Fully OA dbid: AAJSJ link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3daxQxEA-1RfBF_Ha1SgTfdPE2m8_HVSz1QCleC_UpZJOsHpx70r1W7F_vTPYDT6vg62XCDvORmdxMfkPI8yJIg7hSOQ9M5DzOVF4HP8u1L4SGmOJUTA2yH-ThCZ-fitMdwsa3MKlpP0FapmN67A571UGgwcdgcKYiQprML6-RPYRqB9veq6r5Yj79s4K1K16Y4YXMrNRXbN6KQgms_6oM889Gyd-qpSkIHdwiN4fskVY9v7fJTmzvkOv9PMkfd8lRhbXvGChOpA70fdyAilfL7itdthQvmhdpdVF9XNCjHlC1o8ff4-oi0k9g8h1NI8Ppu6FDq71HTg7eHr85zIeRCbmH1GuTS6_q0EgdME5D8sdd0zSO40TxMjADd5_CeDlzM-G1gdxGxDJI1zATFCgHfPU-2W3XbXxIqPO6bhQLwdeGCxMNK2q4_ZUCQQKZChkpRhFaP-CJ41iLlU117VLbXuwWxG6T2O1lRl5Me771aBr_pH6NmpkoEQk7_bA--2wHy7C89kAOWZJkjrvSGd0UUgSjhWy4Vzoj-6Ne7eCenS2MUAybfkxGnk3L4FhYLXFtXJ8jDaRWcGEui4w86M1g4gRHNEOQgN1qy0C2WN1eaZdfEni3EFIx_O7L0ZR-Yeuvonj0f-SPyQ2WrB1OQbZPdjdn5_EJJE-b-ungLT8BqbwSOw priority: 102 providerName: Springer Nature |
| Title | Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection |
| URI | https://link.springer.com/article/10.1038/s41598-017-09536-z https://www.ncbi.nlm.nih.gov/pubmed/28831119 https://www.proquest.com/docview/1957265709 https://www.proquest.com/docview/1931710631 https://pubmed.ncbi.nlm.nih.gov/PMC5567209 https://doaj.org/article/4bc09502862a4a3a98f165d9856f4c78 |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3da9swEBdby2AvY99z1wUN9raZxrI-n4YbWrpAS2hayJ6MLclbIHO6Om1Z__rdyY637KMvNlgylu9Dd9KdfkfIu8RJg7hSMXdMxNwPVVw6O4y1TYQGm1IoHxJkT-TROR_PxKzbcGu6tMr1nBgmare0uEe-lxihGOZpmI8X32OsGoXR1a6Exn2yjdBlKNVqpvo9Foxi8cR0Z2WGqd5rwF7hmTKYmhFoTca3G_YowPb_y9f8O2Xyj7hpMEeHj8mjzo-kWcv4J-Ser5-SB21lyR_PyCTDKLh3FGtTO3rsV8Dsxbz5Ruc1xSXndWidZqdTOmmhVRt6duMX155-BuFvaCgeTj91uVr1c3J-eHA2Ooq74gmxBSdsFUurSldJ7dBigxvIi6qqCo61xVPHDKyCEmPlsBgKqw14OcKnThYVM04Bm0BrX5Cteln7V4QWVpeVYs7Z0nBhvGFJCevAVCBcIFMuIsmahLntkMWxwMUiDxHuVOct2XMgex7Int9G5H3_zkWLq3Fn733kTN8TMbHDg-Xll7xTsZyXFrqDvyRZwYu0MLpKpHBGC1lxq3REdtd8zTtFbfJfYhWRt30zqBjGTYraL6-wDzhZsHROk4i8bMWgHwkWawZzAW-rDQHZGOpmSz3_GmC8hZCK4Xc_rEXpt2H9lxQ7d__Fa_KQBemG-Y_tkq3V5ZV_A27TqhwE3RiQ7SwbT8dw3z84mZzC05EcDcJWBFyPuf4J4QcYXA |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqIgQXxJtAASPBCaImTmzHB4SWR7VLH6roVlpObmI7sNKSLc22Vfuj-I3MOA9YHr31unYU73g830xmPB8hz2MrFPaVClPLeJi6SIaFNVGYmZhngCm5dL5AdkcM99OPEz5ZIT-6uzBYVtnZRG-o7dzgN_L1WHHJsE5DvTn8HiJrFGZXOwqNRi023dkphGz169F72N8XjG18GL8bhi2rQGjAO1mEwsjCliKzCGXgH6V5WZZ5iqTbiWUKwoNYGRHlETeZAvjnLrEiL5myEtYvsfkSmPwrALwRBntyIvtvOpg1S2PV3s2Jkmy9BnzEO2wABdjYTYTnS_jnaQL-5dv-XaL5R57Ww9_GTXKj9VvpoFG0W2TFVbfJ1YbJ8uwO2R1g1t1ZilzYlm67BSjXbFp_o9OKYoh74kf3Bp_26G7TyrWm41M3O3H0M0i1pp6snI7a2rDqLtm_FLHeI6vVvHIPCM1NVpSSWWsKlXLlFIsLiDsTju0JmbQBiTsRatN2MkdCjZn2GfUk043YNYhde7Hr84C87J85bPp4XDj7Le5MPxN7cPsf5kdfdHukdVoYmA7-mWB5mie5yspYcKsyLsrUyCwga92-6tYw1PqXGgfkWT8MRxrzNHnl5sc4B5w6CNWTOCD3GzXoV4Lk0ABP8LRcUpClpS6PVNOvvm0450IyfO-rTpV-W9Z_RfHw4n_xlFwbjre39NZoZ_MRuc68poPtZWtkdXF07B6Dy7YonvhzQsnBZR_Mn0coTeM |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLamTiBeEHc6BhgJniBq4sR2_IBQx1atDKpqF2k8mcR2WKWSjqXbtP00fh3nOEmhXPa219hRnONz9Tk-HyEvIysU9pUKEst4kLhQBrk1YZCaiKdgUzLpfIHsSGwfJB8O-eEK-dHehcGyylYnekVtZwbPyHuR4pJhnYbqFU1ZxHhz8O74e4AIUphpbeE0ahbZcRfnEL5Vb4ebsNevGBts7b_fDhqEgcCApzIPhJG5LURq0ayBr5RkRVFkCQJwx5YpCBUiZUSYhdykClwB7mIrsoIpK-FfJDZiAvW_KjEq6pDVja3ReHdxwoM5tCRSzU2dME57FVhLvNEGhgHbvIngcskaetCAf3m6fxds_pG19cZwcIfcbrxY2q_Z7i5ZceU9cqPGtby4T8Z9zME7SxEZ29JPbg6sNp1U3-ikpBjwnvnRvf7uHh3XjV0run_upmeOfga6VtRDl9NhUylWPiAH10LYh6RTzkr3mNDMpHkhmbUmVwlXTrEoB3rHHJsVMmm7JGpJqE3T1xzhNaba59fjVNdk10B27cmuL7vk9eKd47qrx5WzN3BnFjOxI7d_MDv5qhsB10luYDp4a4JlSRZnKi0iwa1KuSgSI9MuWW_3VTdqotK_mLpLXiyGQcAxa5OVbnaKc8DFg8A9jrrkUc0Gi5UgVDQYK3hbLjHI0lKXR8rJkW8izrmQDL_7pmWl35b1X1KsXf0Xz8lNEEr9cTjaeUJuMc_ooIjZOunMT07dU_Df5vmzRlAo-XLdsvkT07lTfg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Altered+Lipid+Metabolism+in+Recovered+SARS+Patients+Twelve+Years+after+Infection&rft.jtitle=Scientific+reports&rft.au=Wu%2C+Qi&rft.au=Zhou%2C+Lina&rft.au=Sun%2C+Xin&rft.au=Yan%2C+Zhongfang&rft.date=2017-08-22&rft.pub=Nature+Publishing+Group&rft.eissn=2045-2322&rft.volume=7&rft.spage=1&rft_id=info:doi/10.1038%2Fs41598-017-09536-z&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2045-2322&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2045-2322&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2045-2322&client=summon |