FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury

• Published in: Cell reports (Cambridge) Vol. 24; no. 11; pp. 2985 - 2999
• Main Authors: Han, Chang Yeob, Rho, Hyun Soo, Kim, Ayoung, Kim, Tae Hyun, Jang, Kiseok, Jun, Dae Won, Kim, Jong Won, Kim, Bumseok, Kim, Sang Geon
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 11.09.2018; Elsevier
• Subjects: CHOP; ER stress; FXR; inflammasome; NLRP3; PERK; TXNIP; FXR; inflammasome; ER stress; NLRP3; TXNIP; CHOP; PERK

Endoplasmic reticulum (ER) stress is associated with liver injury and fibrosis, and yet the hepatic factors that regulate ER stress-mediated inflammasome activation remain unknown. Here, we report that farnesoid X receptor (FXR) activation inhibits ER stress-induced NACHT, LRR, and PYD domains-conta...