CMTM6 expressed on the adaxonal Schwann cell surface restricts axonal diameters in peripheral nerves

• Published in: Nature communications Vol. 11; no. 1; pp. 4514 - 12
• Main Authors: Eichel, Maria A., Gargareta, Vasiliki-Ilya, D’Este, Elisa, Fledrich, Robert, Kungl, Theresa, Buscham, Tobias J., Lüders, Katja A., Miracle, Cristina, Jung, Ramona B., Distler, Ute, Kusch, Kathrin, Möbius, Wiebke, Hülsmann, Swen, Tenzer, Stefan, Nave, Klaus-Armin, Werner, Hauke B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.09.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 14/19; 14/28; 45/41; 631/378/1959; 631/378/2596/3921; 631/378/87; 64/60; 82/51; Animals; Axonogenesis; Axons; Axons - metabolism; Axons - ultrastructure; Cell membranes; Cell surface; Chemokines; Cryoelectron Microscopy; Humanities and Social Sciences; Male; MARVEL Domain-Containing Proteins - metabolism; Mice; Mice, Knockout; Microscopy; Motor task performance; multidisciplinary; Myelin; Myelin Proteins - metabolism; Myelin Sheath - metabolism; Myelin Sheath - ultrastructure; Myelination; Nerve conduction; Neural Conduction; Peripheral nerves; Peripheral Nerves - cytology; Peripheral Nerves - metabolism; Peripheral Nerves - ultrastructure; Proteomics; Schwann cells; Schwann Cells - cytology; Schwann Cells - metabolism; Schwann Cells - ultrastructure; Science; Science (multidisciplinary); Sensory neurons; Sensory Receptor Cells - cytology; Sensory Receptor Cells - metabolism; Sensory Receptor Cells - ultrastructure

The velocity of nerve conduction is moderately enhanced by larger axonal diameters and potently sped up by myelination of axons. Myelination thus allows rapid impulse propagation with reduced axonal diameters; however, no myelin-dependent mechanism has been reported that restricts radial growth of a...