A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Guérin

• Published in: Nature communications Vol. 12; no. 1; p. 6658
• Main Authors: Woodworth, Joshua S., Clemmensen, Helena Strand, Battey, Hannah, Dijkman, Karin, Lindenstrøm, Thomas, Laureano, Raquel Salvador, Taplitz, Randy, Morgan, Jeffrey, Aagaard, Claus, Rosenkrands, Ida, Lindestam Arlehamn, Cecilia S., Andersen, Peter, Mortensen, Rasmus
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.11.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 13/21; 13/31; 38/91; 631/250/255/1856; 631/250/590/2294; 64/60; 82/29; 82/80; 82/83; Animals; Antigens; Antigens, Bacterial - immunology; Bacillus; BCG Vaccine - administration & dosage; BCG Vaccine - immunology; Cell differentiation; Colonization; Cross-reactivity; Design; Genomes; Helper cells; Humanities and Social Sciences; Humans; Immunity; Immunogenicity, Vaccine; Lymphocytes; Lymphocytes T; Mice; multidisciplinary; Mycobacterium bovis - immunology; Mycobacterium tuberculosis; Mycobacterium tuberculosis - immunology; Science; Science (multidisciplinary); Th1 Cells - immunology; Th17 Cells - immunology; Tuberculosis; Tuberculosis - immunology; Tuberculosis - prevention & control; Tuberculosis Vaccines - administration & dosage; Tuberculosis Vaccines - immunology; Vaccination - methods; Vaccines; Vaccines, Subunit - administration & dosage; Vaccines, Subunit - immunology

Given the encouraging clinical results of both candidate subunit vaccines and revaccination with Bacillus Calmette-Guérin (BCG) against tuberculosis (TB), there is support for combining BCG and subunit vaccination for increased efficacy. BCG and Mycobacterium tuberculosis (Mtb) share ~98% of their g...