The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy - Zingg, Daniel; Arenas-Ramirez, Natalia; Sahin, Dilara; Rosalia, Rodney A.; Antunes, Ana T.; Haeusel, Jessica; Sommer, Lukas; Boyman, Onur (Cell reports (Cambridge), 2017)
Keywords: Animals; anti-CTLA-4; anti-PD-1; Blotting, Western; Cell Line; Chromatin Immunoprecipitation; CTLA-4 Antigen - metabolism; Enhancer of Zeste Homolog 2 Protein - genetics; Enhancer of Zeste Homolog 2 Protein - metabolism; Enzyme-Linked Immunosorbent Assay; epigenetics; EZH2; Female; Flow Cytometry; Fluorescent Antibody Technique; Humans; IL-2 complexes; Immunotherapy; Interleukin-2 - metabolism; melanoma; Melanoma - metabolism; Melanoma - therapy; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; PRC2; T-Lymphocytes - metabolism; tumor immune escape; Tumor Necrosis Factor-alpha - metabolism; tumor resistance; tumor resistance; PRC2; immunotherapy; melanoma; tumor immune escape; anti-CTLA-4; anti-PD-1; IL-2 complexes; epigenetics; EZH2