Towards an arthritis flare-responsive drug delivery system

• Published in: Nature communications Vol. 9; no. 1; pp. 1275 - 11
• Main Authors: Joshi, Nitin, Yan, Jing, Levy, Seth, Bhagchandani, Sachin, Slaughter, Kai V., Sherman, Nicholas E., Amirault, Julian, Wang, Yufeng, Riegel, Logan, He, Xueyin, Rui, Tan Shi, Valic, Michael, Vemula, Praveen K., Miranda, Oscar R., Levy, Oren, Gravallese, Ellen M., Aliprantis, Antonios O., Ermann, Joerg, Karp, Jeffrey M.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.04.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 59; 59/5; 639/166/985; 639/301/54/152; 692/4023/1670/498; Animals; Anti-Inflammatory Agents - administration & dosage; Arthritis; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - metabolism; Biocompatible Materials - chemistry; Chondrocytes - cytology; Dismantling; Drug delivery; Drug Delivery Systems; Drug dosages; Drug Liberation; Enzymes; Fluorescence; Fluorescent dyes; Fluorescent indicators; Humanities and Social Sciences; Humans; Hydrogels; Hydrogels - chemistry; Inflammation; Inflammation - drug therapy; Male; Mice; Mice, Inbred C57BL; Monocytes - cytology; multidisciplinary; Rheumatoid arthritis; Science; Science (multidisciplinary); Symptom Flare Up; Synovial Fluid; Synoviocytes - cytology; Triamcinolone acetonide; Triamcinolone Acetonide - administration & dosage

Local delivery of therapeutics for the treatment of inflammatory arthritis (IA) is limited by short intra-articular half-lives. Since IA severity often fluctuates over time, a local drug delivery method that titrates drug release to arthritis activity would represent an attractive paradigm in IA the...