Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy

Intravascular hemolysis and hemoglobinuria are associated with sickle cell nephropathy. ApoL1 is involved in cell-free hemoglobin scavenging through association with haptoglobin-related protein. APOL1 G1/G2 variants are the strongest genetic predictors of kidney disease in the general African-Americ...

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Bibliographic Details
Published inHaematologica (Roma) Vol. 100; no. 10; pp. 1275 - 1284
Main Authors Saraf, S. L., Zhang, X., Shah, B., Kanias, T., Gudehithlu, K. P., Kittles, R., Machado, R. F., Arruda, J. A. L., Gladwin, M. T., Singh, A. K., Gordeuk, V. R.
Format Journal Article
LanguageEnglish
Published Italy Ferrata Storti Foundation 01.10.2015
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