Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy

• Published in: Haematologica (Roma) Vol. 100; no. 10; pp. 1275 - 1284
• Main Authors: Saraf, S. L., Zhang, X., Shah, B., Kanias, T., Gudehithlu, K. P., Kittles, R., Machado, R. F., Arruda, J. A. L., Gladwin, M. T., Singh, A. K., Gordeuk, V. R.
• Format: Journal Article
• Language: English
• Published: Italy Ferrata Storti Foundation 01.10.2015
• Subjects: Adult; Anemia, Sickle Cell - complications; Anemia, Sickle Cell - genetics; Apolipoprotein L1; Apolipoproteins - genetics; Cell Line; Cohort Studies; Female; Gene Expression; Genetic Predisposition to Disease; Genetic Variation; Genotype; Heme Oxygenase-1 - genetics; Heme Oxygenase-1 - metabolism; Hemoglobins - genetics; Hemoglobins - metabolism; Hemoglobinuria; Hepatitis A Virus Cellular Receptor 1; Humans; Kidney Diseases - etiology; Kidney Diseases - metabolism; Kidney Tubules, Proximal - metabolism; Lipoproteins, HDL - genetics; Male; Membrane Glycoproteins - genetics; Membrane Glycoproteins - urine; Middle Aged; Receptors, Virus - genetics

Intravascular hemolysis and hemoglobinuria are associated with sickle cell nephropathy. ApoL1 is involved in cell-free hemoglobin scavenging through association with haptoglobin-related protein. APOL1 G1/G2 variants are the strongest genetic predictors of kidney disease in the general African-Americ...