Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer

• Published in: Nature communications Vol. 13; no. 1; pp. 954 - 19
• Main Authors: Zhang, Misty Shuo, Cui, Jane Di, Lee, Derek, Yuen, Vincent Wai-Hin, Chiu, David Kung-Chun, Goh, Chi Ching, Cheu, Jacinth Wing-Sum, Tse, Aki Pui-Wah, Bao, Macus Hao-Ran, Wong, Bowie Po Yee, Chen, Carrie Yiling, Wong, Chun-Ming, Ng, Irene Oi-Lin, Wong, Carmen Chak-Lui
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.02.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/106; 14/19; 14/28; 38/15; 59/5; 631/67/2327; 64/60; 692/4020/1503/1504/1610/4029; 82/58; Animals; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - pathology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Line, Tumor; Gene Expression Regulation, Neoplastic - immunology; Gene Knockdown Techniques; Hepatocellular carcinoma; Humanities and Social Sciences; Humans; Hypoxia; Hypoxia-inducible factor 1; Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - pathology; Membrane proteins; Membrane ruffling; Membranes; Mice; Mice, Knockout; multidisciplinary; Nutrients; Pinocytosis - drug effects; Pinocytosis - genetics; Pinocytosis - immunology; Proof of Concept Study; Proteins; Scavenging; Science; Science (multidisciplinary); Transcription; Tumor Hypoxia - genetics; Tumor Hypoxia - immunology; Xenograft Model Antitumor Assays

Hepatocellular carcinoma (HCC) invariably exhibits inadequate O 2 (hypoxia) and nutrient supply. Hypoxia-inducible factor (HIF) mediates cascades of molecular events that enable cancer cells to adapt and propagate. Macropinocytosis is an endocytic process initiated by membrane ruffling, causing the...