Comparisons of Four Protein-Binding Models Characterizing the Pharmacokinetics of Unbound Phenytoin in Adult Patients Using Non-Linear Mixed-Effects Modeling - Jun, Heajin; Rong, Yan; Yih, Catharina; Ho, Jordan; Cheng, Wendy; Kiang, Tony K. L. (Drugs in R&D, 2020)
Keywords: Adult; Aged; Aged, 80 and over; Anticoagulants; Anticonvulsants - administration & dosage; Anticonvulsants - blood; Anticonvulsants - pharmacokinetics; Binding sites; Critical care; Drug dosages; Drug interactions; Drug Monitoring; Enzymes; Female; Humans; Internal Medicine; Male; Medical laboratories; Medicine; Medicine & Public Health; Middle Aged; Models, Biological; Nonlinear Dynamics; Original; Original Research Article; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Phenytoin - administration & dosage; Phenytoin - blood; Phenytoin - pharmacokinetics; Plasma; Protein Binding; Proteins; Retrospective Studies; Serum Albumin - metabolism; Software; Therapeutic drug monitoring; Young Adult