Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast

• Published in: Nature communications Vol. 9; no. 1; pp. 240 - 14
• Main Authors: Lee, Soyun, Oh, Seunghee, Jeong, Kwiwan, Jo, Hyelim, Choi, Yoonjung, Seo, Hogyu David, Kim, Minhoo, Choe, Joonho, Kwon, Chang Seob, Lee, Daeyoup
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.01.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 45/15; 45/91; 631/337/100/101; 631/337/100/1701; 82/29; Chromatin; Chromatin remodeling; Eukaryotes; Histone H3; Histones; Humanities and Social Sciences; Lysine; Methylation; multidisciplinary; Nucleosomes; Science; Science (multidisciplinary); Transcription; Yeast

Dot1 (disruptor of telomeric silencing-1, DOT1L in humans) is the only known enzyme responsible for histone H3 lysine 79 methylation (H3K79me) and is evolutionarily conserved in most eukaryotes. Yeast Dot1p lacks a SET domain and does not methylate free histones and thus may have different actions w...