LncRNA and mRNA expression profile of peripheral blood mononuclear cells in primary Sjögren’s syndrome patients

• Published in: Scientific reports Vol. 10; no. 1; p. 19629
• Main Authors: Peng, Yu, Luo, Xuan, Chen, Yingying, Peng, Linyi, Deng, Chuiwen, Fei, Yunyun, Zhang, Wen, Zhao, Yan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.11.2020; Nature Publishing Group
• Subjects: 631/250; 692/4023; 692/420; Adult; Female; Gene expression; Gene Expression Profiling; Humanities and Social Sciences; Humans; Immune response; Immune system; Leukocytes (mononuclear); Leukocytes, Mononuclear - immunology; Leukocytes, Mononuclear - metabolism; Localization; Male; MAP Kinase Signaling System; Metastases; Metastasis; Middle Aged; multidisciplinary; NF-kappa B; NF-κB protein; Non-coding RNA; Peripheral blood mononuclear cells; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Science; Science (multidisciplinary); Sjogren's syndrome; Sjogren's Syndrome - blood; Sjogren's Syndrome - genetics; Sjogren's Syndrome - immunology; Transcriptome - genetics

The aim of this study was to elucidate the expression profile and the potential role of long non-coding RNA (LncRNA) in the peripheral blood mononuclear cells of primary Sjögren’s syndrome (pSS) patients. RNA-seq technology was used to detect the differentially expressed LncRNAs and mRNAs between fi...