Antifibrotic action of Yifei Sanjie formula enhanced autophagy via PI3K-AKT-mTOR signaling pathway in mouse model of pulmonary fibrosis

• Published in: Biomedicine & pharmacotherapy Vol. 118; p. 109293
• Main Authors: Yu, Jing-Ze, Ying, Yi, Liu, Yang, Sun, Chun-Bin, Dai, Chen, Zhao, Shan, Tian, Shou-Zheng, Peng, Jing, Han, Ni-Ping, Yuan, Jia-Li, Yan, Jin-Yuan, Yang, Zhong-Shan
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.10.2019; Elsevier
• Subjects: Animals; Autophagosomes - metabolism; Autophagosomes - ultrastructure; Autophagy - drug effects; Collagen - metabolism; Disease Models, Animal; Drugs, Chinese Herbal; Humans; Inflammation - complications; Inflammation - pathology; Lung - pathology; Male; Phosphatidylinositol 3-Kinases - metabolism; Phosphorylation - drug effects; Proto-Oncogene Proteins c-akt - metabolism; Pulmonary Fibrosis - complications; Pulmonary Fibrosis - drug therapy; Pulmonary Fibrosis - metabolism; Pulmonary Fibrosis - pathology; Signal Transduction; TOR Serine-Threonine Kinases - metabolism; Transforming Growth Factor beta1 - metabolism

[Display omitted] •Yifei Sanjie formula (YFSJF) reduces the inflammatory injuring and collagen deposition in BLM-induced PF mice.•Autophagy is triggered by YFSJF and inhibition of autophagy may contribute to the promotion of lung fibrosis.•YFSJF inhibits the PI3K-AKT-mTOR signaling pathway in BLM-in...