Contrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes

• Published in: Nature communications Vol. 11; no. 1; p. 2238
• Main Authors: Ramirez, David G., Abenojar, Eric, Hernandez, Christopher, Lorberbaum, David S., Papazian, Lucine A., Passman, Samantha, Pham, Vinh, Exner, Agata A., Benninger, Richard K. P.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 07.05.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 14/34; 639/925/352/2734; 692/699/249/1313/1418; Accumulation; Animal models; Animals; Backscattering; Beta cells; Contrast agents; Contrast Media; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - diagnostic imaging; Diabetes Mellitus, Type 1 - pathology; Female; Humanities and Social Sciences; Humans; Immune system; Insulin; Insulin-Secreting Cells - pathology; Insulitis; Islets of Langerhans; Islets of Langerhans - diagnostic imaging; Islets of Langerhans - pathology; Lymphocytes T; Mice; Microvasculature; multidisciplinary; Nanoparticles; Pancreas; Pancreas - diagnostic imaging; Pancreas - pathology; Permeability; Science; Science (multidisciplinary); Signs and symptoms; Ultrasonic imaging; Ultrasonic methods; Ultrasonic testing; Ultrasonography; Ultrasound

In type1 diabetes (T1D) autoreactive T-cells infiltrate the islets of Langerhans, depleting insulin-secreting β-cells (insulitis). Insulitis arises during an asymptomatic phase, prior to clinical diagnosis of T1D. Methods to diagnose insulitis and β-cell mass changes during this asymptomatic phase a...