Cytotoxicity and genotoxicity of 1,4-bisdesoxyquinocetone, 3-methylquinoxaline-2-carboxylic acid (MQCA) in human hepatocytes

• Published in: Research in veterinary science Vol. 93; no. 3; pp. 1393 - 1401
• Main Authors: Zhang, Keyu, Ban, Manman, Zhao, Zhanzhong, Zheng, Haihong, Wang, Xiaoyang, Wang, Mi, Fei, Chenzhong, Xue, Feiqun
• Format: Journal Article
• Language: English
• Published: England Elsevier India Pvt Ltd 01.12.2012; Elsevier Limited
• Subjects: 1,4-Bisdesoxyquinocetone; 3-Methylquinoxaline-2-carboxylic acid; Cell culture; Cell Survival; Cell Survival - drug effects; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA damage; DNA Damage - drug effects; Drug dosages; drug effects; drugs; feed additives; Feeds; flow cytometry; Genotoxicity; hepatocytes; Hepatocytes - drug effects; hormesis; Humans; interphase; Laboratory animals; Metabolite; Metabolites; Mutagenicity Tests; olaquindox; pharmacology; Quinoxalines; Quinoxalines - pharmacology; Science; Studies; Veterinary medicine; China; Cytotoxicity; 1,4-Bisdesoxyquinocetone; 3-Methylquinoxaline-2-carboxylic acid; Metabolite; Genotoxicity

Quinoxaline-1,4-dioxides, widely used as medicinal feed additives as antibacterial growth promoters, have been shown to exert diverse toxicities. Their toxicities are hypothesized to be closely related to the formation of N-oxide reductive metabolites. 1,4-Bisdesoxyquinocetone and MQCA are important...