MYH9-dependent polarization of ATG9B promotes colorectal cancer metastasis by accelerating focal adhesion assembly

• Published in: Cell death and differentiation Vol. 28; no. 12; pp. 3251 - 3269
• Main Authors: Zhong, Yan, Long, Ting, Gu, Chuan-Sha, Tang, Jing-Yi, Gao, Ling-Fang, Zhu, Jia-Xian, Hu, Zhi-Yan, Wang, Xia, Ma, Yi-Dan, Ding, Yan-Qing, Li, Zu-Guo, Wang, Xiao-Yan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2021; Nature Publishing Group
• Subjects: 13/1; 13/109; 38/109; 42/89; 631/67/322; 631/67/395; 64/60; 82/51; 82/83; 96/106; Animals; Apoptosis; Autophagy; Autophagy-Related Proteins - metabolism; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - genetics; Colorectal Neoplasms - mortality; Colorectal Neoplasms - pathology; Female; Focal Adhesions - metabolism; Humans; Life Sciences; Membrane Proteins - metabolism; Metastases; Metastasis; Mice; Myosin Heavy Chains - metabolism; Neoplasm Metastasis; Phagocytosis; Prognosis; Stem Cells; Survival Analysis; Talin; Tumors; Ubiquitin; Ubiquitin-protein ligase

Tumour metastasis is a major reason accounting for the poor prognosis of colorectal cancer (CRC), and the discovery of targets in the primary tumours that can predict the risk of CRC metastasis is now urgently needed. In this study, we identified autophagy-related protein 9B (ATG9B) as a key potenti...