Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity

• Published in: Nature communications Vol. 13; no. 1; p. 4075
• Main Authors: Hanna, Joachim, Beke, Flavio, O’Brien, Louise M., Kapeni, Chrysa, Chen, Hung-Chang, Carbonaro, Valentina, Kim, Alexander B., Kishore, Kamal, Adolph, Timon E., Skjoedt, Mikkel-Ole, Skjoedt, Karsten, de la Roche, Marc, de la Roche, Maike
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.07.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/106; 13/31; 13/51; 14/19; 38; 38/35; 38/39; 38/91; 45/88; 45/90; 631/250/1619/554/1898; 631/250/1619/554/1898/1273; 631/250/2152/1566/2493; 631/80/86/2370; 64; 64/60; 96; 96/21; Ablation; Adult; Animal models; Animals; Autoimmune diseases; CD4 antigen; Cell fate; Colitis, Ulcerative - drug therapy; Colitis, Ulcerative - genetics; Embryogenesis; Embryonic growth stage; Hedgehog protein; Hedgehog Proteins - genetics; Hedgehog Proteins - metabolism; Helper cells; Humanities and Social Sciences; Humans; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; Ligands; Lymphocytes; Lymphocytes T; Mice; multidisciplinary; Pathogenicity; Pathogens; Pattern formation; Polarization; Science; Science (multidisciplinary); Signal Transduction; Signaling; Th17 Cells; Therapeutic targets; Ulcerative colitis; Virulence

Th17 cells are key drivers of autoimmune disease. However, the signaling pathways regulating Th17 polarization are poorly understood. Hedgehog signaling regulates cell fate decisions during embryogenesis and adult tissue patterning. Here we find that cell-autonomous Hedgehog signaling, independent o...