Epigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease

• Published in: Nature communications Vol. 12; no. 1; pp. 5134 - 18
• Main Authors: Gordevicius, Juozas, Li, Peipei, Marshall, Lee L., Killinger, Bryan A., Lang, Sean, Ensink, Elizabeth, Kuhn, Nathan C., Cui, Wei, Maroof, Nazia, Lauria, Roberta, Rueb, Christina, Siebourg-Polster, Juliane, Maliver, Pierre, Lamp, Jared, Vega, Irving, Manfredsson, Fredric P., Britschgi, Markus, Labrie, Viviane
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 45/15; 45/23; 45/91; 631/378; 631/378/1689/1718; 631/378/2584; 82/58; Abnormalities; alpha-Synuclein - chemistry; alpha-Synuclein - genetics; alpha-Synuclein - metabolism; Animals; Appendix - chemistry; Appendix - metabolism; Autophagy; Brain - metabolism; Brain - pathology; Deoxyribonucleic acid; Disruption; DNA; DNA Methylation; DNA sequencing; Epigenesis, Genetic; Epigenetics; Female; Gastrointestinal system; Gastrointestinal tract; Genes; Humanities and Social Sciences; Humans; Inactivation; Lysosomes - chemistry; Lysosomes - genetics; Lysosomes - metabolism; Male; Mice; Mice, Inbred C57BL; Movement disorders; multidisciplinary; Neurodegenerative diseases; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Pathology; Phagocytosis; Protein Aggregates; Science; Science (multidisciplinary); Synuclein

The gastrointestinal tract may be a site of origin for α-synuclein pathology in idiopathic Parkinson’s disease (PD). Disruption of the autophagy-lysosome pathway (ALP) may contribute to α-synuclein aggregation. Here we examined epigenetic alterations in the ALP in the appendix by deep sequencing DNA...