Mechanoradicals in tensed tendon collagen as a source of oxidative stress

• Published in: Nature communications Vol. 11; no. 1; p. 2315
• Main Authors: Zapp, Christopher, Obarska-Kosinska, Agnieszka, Rennekamp, Benedikt, Kurth, Markus, Hudson, David M., Mercadante, Davide, Barayeu, Uladzimir, Dick, Tobias P., Denysenkov, Vasyl, Prisner, Thomas, Bennati, Marina, Daday, Csaba, Kappl, Reinhard, Gräter, Frauke
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.05.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 140/58; 631/57/2268; 639/301/54/1754; 64/86; Animals; Biocompatible Materials - chemistry; Biopolymers - chemistry; Cleavage; Collagen; Collagen (type I); Collagen - chemistry; Cross-linking; Crosslinking; Damage; Dihydroxyphenylalanine; Dihydroxyphenylalanine - chemistry; Electron Spin Resonance Spectroscopy; Free Radicals - chemistry; Humanities and Social Sciences; Hydrogen peroxide; Molecular dynamics; multidisciplinary; Oxidation-Reduction; Oxidative Stress; Paramagnetic resonance; Polymers; Proteins; Quantum chemistry; Radicals; Rats; Reactive oxygen species; Reactive Oxygen Species - chemistry; Science; Science (multidisciplinary); Spectroscopy; Tendons - chemistry

As established nearly a century ago, mechanoradicals originate from homolytic bond scission in polymers. The existence, nature and biological relevance of mechanoradicals in proteins, instead, are unknown. We here show that mechanical stress on collagen produces radicals and subsequently reactive ox...