Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy

• Published in: Nature communications Vol. 13; no. 1; pp. 5392 - 17
• Main Authors: Korir, Michelle L., Doster, Ryan S., Lu, Jacky, Guevara, Miriam A., Spicer, Sabrina K., Moore, Rebecca E., Francis, Jamisha D., Rogers, Lisa M., Haley, Kathryn P., Blackman, Amondrea, Noble, Kristen N., Eastman, Alison J., Williams, Janice A., Damo, Steven M., Boyd, Kelli L., Townsend, Steven D., Henrique Serezani, C., Aronoff, David M., Manning, Shannon D., Gaddy, Jennifer A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.09.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 14; 14/19; 14/28; 631/250/254; 631/326/41/2534; 631/326/41/88; 631/326/421; 64/60; Animals; Bacteria; Birth; Cytokines; Depletion; Detoxification; Efflux; Female; Gene deletion; Gene expression; Humanities and Social Sciences; Humans; Immune system; Infant, Newborn; Infections; Leukocyte Count; Macrophages; Macrophages - microbiology; Metals; Mice; multidisciplinary; Neonates; Perinatal infection; Pregnancy; Premature birth; Premature Birth - microbiology; Reproductive system; Science; Science (multidisciplinary); Sepsis; Stillbirth; Streptococcus; Streptococcus agalactiae; Streptococcus agalactiae - genetics; Streptococcus infections; Survival; Toxicity

Perinatal infection with Streptococcus agalactiae , or Group B Streptococcus (GBS), is associated with preterm birth, neonatal sepsis, and stillbirth. Here, we study the interactions of GBS with macrophages, essential sentinel immune cells that defend the gravid reproductive tract. Transcriptional a...