Efficacy of Cyclophosphamide treatment for immunoglobulin G4-related disease with addition of glucocorticoids

• Published in: Scientific reports Vol. 7; no. 1; pp. 6195 - 8
• Main Authors: Yunyun, Fei, Yu, Chen, Panpan, Zhang, Hua, Chen, Di, Wu, Lidan, Zhao, Linyi, Peng, Li, Wang, Qingjun, Wu, Xuan, Zhang, Yan, Zhao, Xiaofeng, Zeng, Fengchun, Zhang, Wen, Zhang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 21.07.2017; Nature Publishing Group; Nature Portfolio
• Subjects: 692/4023/1670; 692/699/249/1313; Adult; Autoimmune diseases; Bile ducts; Cyclophosphamide; Cyclophosphamide - administration & dosage; Cyclophosphamide - therapeutic use; Drug Administration Schedule; Drug Therapy, Combination; Female; Glands; Glucocorticoids; Hospitals; Humanities and Social Sciences; Humans; Immunoglobulin G; Immunoglobulin G4; Immunoglobulin G4-Related Disease - drug therapy; Immunoglobulins; Immunosuppressive agents; Lymph nodes; Male; Medical schools; Middle Aged; multidisciplinary; Prednisone; Prednisone - administration & dosage; Prednisone - therapeutic use; Prospective Studies; Recurrence; Remission; Science; Science (multidisciplinary); Serology; Systemic diseases; Treatment Outcome

Aim to evaluate the efficacy and safety of glucocorticoid monotherapy vs combination therapy of cyclophosphamide (CYC) for IgG4 related disease (IgG4-RD). 102 newly diagnosed IgG4-RD patients were enrolled and assigned to 2 groups: Group I was prednisone monotherapy (0.5–1.0 mg/kg.d, tapered gradual...