Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

• Published in: Nature communications Vol. 10; no. 1; pp. 5348 - 9
• Main Authors: Vijayakrishnan, Jayaram, Qian, Maoxiang, Studd, James B., Yang, Wenjian, Kinnersley, Ben, Law, Philip J., Broderick, Peter, Raetz, Elizabeth A., Allan, James, Pui, Ching-Hon, Vora, Ajay, Evans, William E., Moorman, Anthony, Yeoh, Allen, Yang, Wentao, Li, Chunliang, Bartram, Claus R., Mullighan, Charles G., Zimmerman, Martin, Hunger, Stephen P., Schrappe, Martin, Relling, Mary V., Stanulla, Martin, Loh, Mignon L., Houlston, Richard S., Yang, Jun J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.11.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 45; 45/43; 631/208/205/2138; 631/67/1990/283/2125; 631/67/2332; 692/4028/67/1990/283/2125; Acute lymphoblastic leukemia; bcl-2 Homologous Antagonist-Killer Protein - genetics; Blood cancer; Cell cycle; Child; Chromatin; Chromosome 9; Core Binding Factor Alpha 2 Subunit - genetics; Deregulation; Epigenomics; Genetic Predisposition to Disease - genetics; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomic analysis; Humanities and Social Sciences; Humans; Leukemia; Loci; Lymphocytes B; multidisciplinary; Oncogene Proteins, Fusion - genetics; Polymorphism, Single Nucleotide; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology; Risk; Risk Factors; RNA-Binding Proteins - genetics; Runx1 protein; Science; Science (multidisciplinary); Transcriptome

There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666...