Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk

There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 10; no. 1; pp. 5348 - 9
Main Authors Vijayakrishnan, Jayaram, Qian, Maoxiang, Studd, James B., Yang, Wenjian, Kinnersley, Ben, Law, Philip J., Broderick, Peter, Raetz, Elizabeth A., Allan, James, Pui, Ching-Hon, Vora, Ajay, Evans, William E., Moorman, Anthony, Yeoh, Allen, Yang, Wentao, Li, Chunliang, Bartram, Claus R., Mullighan, Charles G., Zimmerman, Martin, Hunger, Stephen P., Schrappe, Martin, Relling, Mary V., Stanulla, Martin, Loh, Mignon L., Houlston, Richard S., Yang, Jun J.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 25.11.2019
Nature Publishing Group
Nature Portfolio
Subjects
45
45/43
631/208/205/2138
631/67/1990/283/2125
631/67/2332
692/4028/67/1990/283/2125
Acute lymphoblastic leukemia
bcl-2 Homologous Antagonist-Killer Protein - genetics
Blood cancer
Cell cycle
Child
Chromatin
Chromosome 9
Core Binding Factor Alpha 2 Subunit - genetics
Deregulation
Epigenomics
Genetic Predisposition to Disease - genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomic analysis
Humanities and Social Sciences
Humans
Leukemia
Loci
Lymphocytes B
multidisciplinary
Oncogene Proteins, Fusion - genetics
Polymorphism, Single Nucleotide
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology
Risk
Risk Factors
RNA-Binding Proteins - genetics
Runx1 protein
Science
Science (multidisciplinary)
Transcriptome
Online AccessGet full text

Cover

Abstract There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P  = 2.11 × 10 −8 ), for high-hyperdiploid ALL at 5q31.1 (rs886285, P  = 1.56 × 10 −8 ) and 6p21.31 (rs210143 in BAK1 , P   =  2.21 × 10 −8 ), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1 , P  = 1.82 × 10 −8 ). Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haematological malignancies and specific effects of IGF2BP1 on ETV6-RUNX1 ALL evidenced by both germline and somatic genomic analyses. Integration of GWAS signals with transcriptomic/epigenomic profiling and 3D chromatin interaction data for these leukaemia risk loci suggests deregulation of B-cell development and the cell cycle as central mechanisms governing genetic susceptibility to ALL. B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling indicates cell-cycle and B-cell development deregulation as central mechanisms in B-ALL susceptibility, often in a subtype-specific fashion.
AbstractList There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P = 2.11 × 10 ), for high-hyperdiploid ALL at 5q31.1 (rs886285, P = 1.56 × 10 ) and 6p21.31 (rs210143 in BAK1, P = 2.21 × 10 ), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1, P = 1.82 × 10 ). Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haematological malignancies and specific effects of IGF2BP1 on ETV6-RUNX1 ALL evidenced by both germline and somatic genomic analyses. Integration of GWAS signals with transcriptomic/epigenomic profiling and 3D chromatin interaction data for these leukaemia risk loci suggests deregulation of B-cell development and the cell cycle as central mechanisms governing genetic susceptibility to ALL.
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P = 2.11 × 10-8), for high-hyperdiploid ALL at 5q31.1 (rs886285, P = 1.56 × 10-8) and 6p21.31 (rs210143 in BAK1, P = 2.21 × 10-8), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1, P = 1.82 × 10-8). Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haematological malignancies and specific effects of IGF2BP1 on ETV6-RUNX1 ALL evidenced by both germline and somatic genomic analyses. Integration of GWAS signals with transcriptomic/epigenomic profiling and 3D chromatin interaction data for these leukaemia risk loci suggests deregulation of B-cell development and the cell cycle as central mechanisms governing genetic susceptibility to ALL.There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P = 2.11 × 10-8), for high-hyperdiploid ALL at 5q31.1 (rs886285, P = 1.56 × 10-8) and 6p21.31 (rs210143 in BAK1, P = 2.21 × 10-8), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1, P = 1.82 × 10-8). Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haematological malignancies and specific effects of IGF2BP1 on ETV6-RUNX1 ALL evidenced by both germline and somatic genomic analyses. Integration of GWAS signals with transcriptomic/epigenomic profiling and 3D chromatin interaction data for these leukaemia risk loci suggests deregulation of B-cell development and the cell cycle as central mechanisms governing genetic susceptibility to ALL.
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P = 2.11 × 10−8), for high-hyperdiploid ALL at 5q31.1 (rs886285, P = 1.56 × 10−8) and 6p21.31 (rs210143 in BAK1, P = 2.21 × 10−8), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1, P = 1.82 × 10−8). Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haematological malignancies and specific effects of IGF2BP1 on ETV6-RUNX1 ALL evidenced by both germline and somatic genomic analyses. Integration of GWAS signals with transcriptomic/epigenomic profiling and 3D chromatin interaction data for these leukaemia risk loci suggests deregulation of B-cell development and the cell cycle as central mechanisms governing genetic susceptibility to ALL.
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P  = 2.11 × 10 −8 ), for high-hyperdiploid ALL at 5q31.1 (rs886285, P  = 1.56 × 10 −8 ) and 6p21.31 (rs210143 in BAK1 , P   =  2.21 × 10 −8 ), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1 , P  = 1.82 × 10 −8 ). Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haematological malignancies and specific effects of IGF2BP1 on ETV6-RUNX1 ALL evidenced by both germline and somatic genomic analyses. Integration of GWAS signals with transcriptomic/epigenomic profiling and 3D chromatin interaction data for these leukaemia risk loci suggests deregulation of B-cell development and the cell cycle as central mechanisms governing genetic susceptibility to ALL. B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling indicates cell-cycle and B-cell development deregulation as central mechanisms in B-ALL susceptibility, often in a subtype-specific fashion.
B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association studies, totalling 5,321 cases and 16,666 controls of European descent, identifying B-ALL risk loci, whose integration with epigenomic profiling indicates cell-cycle and B-cell development deregulation as central mechanisms in B-ALL susceptibility, often in a subtype-specific fashion.
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P  = 2.11 × 10 −8 ), for high-hyperdiploid ALL at 5q31.1 (rs886285, P  = 1.56 × 10 −8 ) and 6p21.31 (rs210143 in BAK1 , P   =  2.21 × 10 −8 ), and ETV6-RUNX1 ALL at 17q21.32 (rs10853104 in IGF2BP1 , P  = 1.82 × 10 −8 ). Particularly notable are the pleiotropic effects of the BAK1 variant on multiple haematological malignancies and specific effects of IGF2BP1 on ETV6-RUNX1 ALL evidenced by both germline and somatic genomic analyses. Integration of GWAS signals with transcriptomic/epigenomic profiling and 3D chromatin interaction data for these leukaemia risk loci suggests deregulation of B-cell development and the cell cycle as central mechanisms governing genetic susceptibility to ALL.
ArticleNumber 5348
Author Bartram, Claus R.
Yang, Wentao
Evans, William E.
Stanulla, Martin
Yeoh, Allen
Yang, Wenjian
Li, Chunliang
Qian, Maoxiang
Mullighan, Charles G.
Loh, Mignon L.
Houlston, Richard S.
Relling, Mary V.
Kinnersley, Ben
Vora, Ajay
Allan, James
Pui, Ching-Hon
Schrappe, Martin
Yang, Jun J.
Zimmerman, Martin
Vijayakrishnan, Jayaram
Law, Philip J.
Hunger, Stephen P.
Studd, James B.
Broderick, Peter
Moorman, Anthony
Raetz, Elizabeth A.
Author_xml – sequence: 1
  givenname: Jayaram
  orcidid: 0000-0002-8284-2249
  surname: Vijayakrishnan
  fullname: Vijayakrishnan, Jayaram
  organization: Division of Genetics and Epidemiology, The Institute of Cancer Research
– sequence: 2
  givenname: Maoxiang
  surname: Qian
  fullname: Qian, Maoxiang
  organization: Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Children’s Hospital and Institutes of Biomedical Sciences, Fudan University
– sequence: 3
  givenname: James B.
  orcidid: 0000-0002-7157-754X
  surname: Studd
  fullname: Studd, James B.
  organization: Division of Genetics and Epidemiology, The Institute of Cancer Research
– sequence: 4
  givenname: Wenjian
  surname: Yang
  fullname: Yang, Wenjian
  organization: Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital
– sequence: 5
  givenname: Ben
  orcidid: 0000-0003-1783-6296
  surname: Kinnersley
  fullname: Kinnersley, Ben
  organization: Division of Genetics and Epidemiology, The Institute of Cancer Research
– sequence: 6
  givenname: Philip J.
  orcidid: 0000-0001-9663-4611
  surname: Law
  fullname: Law, Philip J.
  organization: Division of Genetics and Epidemiology, The Institute of Cancer Research
– sequence: 7
  givenname: Peter
  orcidid: 0000-0002-8348-5829
  surname: Broderick
  fullname: Broderick, Peter
  organization: Division of Genetics and Epidemiology, The Institute of Cancer Research
– sequence: 8
  givenname: Elizabeth A.
  surname: Raetz
  fullname: Raetz, Elizabeth A.
  organization: Division of Pediatric Hematology and Oncology, New York University Langone Health
– sequence: 9
  givenname: James
  surname: Allan
  fullname: Allan, James
  organization: Northern Institute for Cancer Research, Newcastle University
– sequence: 10
  givenname: Ching-Hon
  orcidid: 0000-0003-0303-5658
  surname: Pui
  fullname: Pui, Ching-Hon
  organization: Department of Oncology, St. Jude Children’s Research Hospital, Hematological Malignancies Program, St. Jude Children’s Research Hospital
– sequence: 11
  givenname: Ajay
  surname: Vora
  fullname: Vora, Ajay
  organization: Great Ormond Hospital
– sequence: 12
  givenname: William E.
  orcidid: 0000-0002-9333-5322
  surname: Evans
  fullname: Evans, William E.
  organization: Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Hematological Malignancies Program, St. Jude Children’s Research Hospital
– sequence: 13
  givenname: Anthony
  surname: Moorman
  fullname: Moorman, Anthony
  organization: Wolfson Childhood Cancer Research Centre, Northern Institute for Cancer Research, Newcastle University
– sequence: 14
  givenname: Allen
  surname: Yeoh
  fullname: Yeoh, Allen
  organization: Centre for Translational Research in Acute Leukaemia, Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, VIVA–University Children’s Cancer Centre, Khoo Teck Puat–National University Children’s Medical Institute, National University Hospital, National University Health System
– sequence: 15
  givenname: Wentao
  surname: Yang
  fullname: Yang, Wentao
  organization: Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital
– sequence: 16
  givenname: Chunliang
  orcidid: 0000-0002-5938-5510
  surname: Li
  fullname: Li, Chunliang
  organization: Department of Tumor Cell Biology, St. Jude Children’s Research Hospital
– sequence: 17
  givenname: Claus R.
  surname: Bartram
  fullname: Bartram, Claus R.
  organization: Institute of Human Genetics, University Hospital
– sequence: 18
  givenname: Charles G.
  orcidid: 0000-0002-1871-1850
  surname: Mullighan
  fullname: Mullighan, Charles G.
  organization: Department of Oncology, St. Jude Children’s Research Hospital, Hematological Malignancies Program, St. Jude Children’s Research Hospital, Department of Pathology, St. Jude Children’s Research Hospital
– sequence: 19
  givenname: Martin
  surname: Zimmerman
  fullname: Zimmerman, Martin
  organization: Department of Paediatric Haematology and Oncology, Hannover Medical School
– sequence: 20
  givenname: Stephen P.
  surname: Hunger
  fullname: Hunger, Stephen P.
  organization: Department of Paediatrics and Centre for Childhood Cancer Research, Children’s Hospital of Philadelphia and the Perelman School of Medicine at The University of Pennsylvania
– sequence: 21
  givenname: Martin
  surname: Schrappe
  fullname: Schrappe, Martin
  organization: Department of Paediatrics, University Medical Centre Schleswig-Holstein
– sequence: 22
  givenname: Mary V.
  surname: Relling
  fullname: Relling, Mary V.
  organization: Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Hematological Malignancies Program, St. Jude Children’s Research Hospital
– sequence: 23
  givenname: Martin
  surname: Stanulla
  fullname: Stanulla, Martin
  organization: Department of Paediatric Haematology and Oncology, Hannover Medical School
– sequence: 24
  givenname: Mignon L.
  surname: Loh
  fullname: Loh, Mignon L.
  organization: Department of Pediatrics, Benioff Children’s Hospital and the Helen Diller Family Comprehensive Cancer Center, University of California San Francisco
– sequence: 25
  givenname: Richard S.
  orcidid: 0000-0002-5268-0242
  surname: Houlston
  fullname: Houlston, Richard S.
  email: richard.houlston@icr.ac.uk
  organization: Division of Genetics and Epidemiology, The Institute of Cancer Research
– sequence: 26
  givenname: Jun J.
  orcidid: 0000-0002-0770-9659
  surname: Yang
  fullname: Yang, Jun J.
  email: Jun.Yang@stjude.org
  organization: Department of Pharmaceutical Sciences, St. Jude Children’s Research Hospital, Department of Oncology, St. Jude Children’s Research Hospital, Hematological Malignancies Program, St. Jude Children’s Research Hospital
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31767839$$D View this record in MEDLINE/PubMed
BookMark eNp9Uk1v1DAUtFARLaV_gAOKxIVLwI4df1yQoOJjpUpcQBwtx3neeuvEi51U6r_H2bTQ9lBfbD3PzBuP30t0NMYREHpN8HuCqfyQGWFc1JiomlDMVc2foZMGM1IT0dCje-djdJbzDpdFFZGMvUDHlAguJFUn6Pemh3Hyzlsz-ThW0VUuzqka4zWEyuQcrT_c5FJP1efaQih1O09QhZthfxm7YPLkbRVgvjIweFMln69eoefOhAxnt_sp-vX1y8_z7_XFj2-b808XtW0Znuq2Fx12DTgmgBjSWOkk2LYhXLKuvAtY52jHbC8aMEYRyjprcMdti4mFvqenaLPq9tHs9D75waQbHY3Xh0JMW21SsRdAO2BKuVYCtR1rBVbG4NKQYMGs40QVrY-r1n7uBuhtCSaZ8ED04c3oL_U2XmsuhWg5KQLvbgVS_DNDnvTg8xKYGSHOWTeUSFGyb5debx9BdyX2sUS1oISikjcL6s19R_-s3P1fAcgVYFPMOYHT1k-H_yoGfdAE62Va9DotukyLPkyL5oXaPKLeqT9JoispF_C4hfTf9hOsvyUx0rA
CitedBy_id crossref_primary_10_1016_j_xhgg_2024_100356
crossref_primary_10_1186_s13046_022_02585_x
crossref_primary_10_3324_haematol_2022_281157
crossref_primary_10_3389_fonc_2020_550213
crossref_primary_10_1007_s12672_022_00465_6
crossref_primary_10_1038_s41572_024_00525_x
crossref_primary_10_1097_MOP_0000000000001419
crossref_primary_10_1126_science_abk3512
crossref_primary_10_3390_genes13020330
crossref_primary_10_1158_2643_3230_BCD_20_0011
crossref_primary_10_1093_jnci_djac101
crossref_primary_10_1186_s13046_023_02810_1
crossref_primary_10_1158_1055_9965_EPI_20_0113
crossref_primary_10_1093_jnci_djac151
crossref_primary_10_1016_j_xhgg_2023_100239
crossref_primary_10_1093_hmg_ddac137
crossref_primary_10_1158_0008_5472_CAN_21_1191
crossref_primary_10_1016_j_it_2021_03_004
crossref_primary_10_3389_fgene_2021_554948
crossref_primary_10_1016_j_omtn_2020_12_018
crossref_primary_10_3390_jpm12060856
crossref_primary_10_1002_pbc_29402
crossref_primary_10_1186_s12864_024_11068_6
crossref_primary_10_1007_s10162_021_00801_7
crossref_primary_10_1016_j_gene_2021_146132
crossref_primary_10_1038_s41375_021_01225_1
crossref_primary_10_1007_s11684_020_0821_6
crossref_primary_10_1038_s41577_021_00505_2
crossref_primary_10_1038_s41467_024_48124_4
crossref_primary_10_1186_s12916_024_03385_0
crossref_primary_10_1093_hmg_ddab336
crossref_primary_10_1182_blood_2019004381
crossref_primary_10_1182_blood_2020009895
crossref_primary_10_1002_jha2_166
crossref_primary_10_1093_jleuko_qiae015
crossref_primary_10_1007_s13237_024_00466_6
crossref_primary_10_1093_jnci_djaa139
crossref_primary_10_18632_aging_202903
crossref_primary_10_1242_dmm_049857
crossref_primary_10_1038_s41375_021_01465_1
crossref_primary_10_1097_MPH_0000000000002648
crossref_primary_10_3390_cancers12123854
crossref_primary_10_1007_s00204_024_03881_5
crossref_primary_10_1038_s41598_021_90542_7
crossref_primary_10_1186_s12935_020_01524_0
crossref_primary_10_1038_s41568_024_00775_7
crossref_primary_10_1007_s12672_022_00602_1
crossref_primary_10_1016_j_humimm_2025_111301
crossref_primary_10_1007_s00112_020_01082_9
crossref_primary_10_1002_cncr_33678
crossref_primary_10_1016_j_ajhg_2021_08_004
crossref_primary_10_1016_j_xgen_2024_100526
crossref_primary_10_3389_fgene_2020_01004
crossref_primary_10_1146_annurev_pathmechdis_051122_100856
Cites_doi 10.1073/pnas.0506637102
10.1182/blood-2018-07-862946
10.1038/leu.2008.152
10.1038/nbt1010-1045
10.1182/blood-2017-02-766204
10.1182/blood-2004-04-1616
10.1182/blood.V82.9.2611.2611
10.1038/ng1847
10.1126/science.278.5340.1068
10.1038/ng.2653
10.1073/pnas.0504783102
10.1016/j.molcel.2015.04.011
10.1038/nature10334
10.1200/JCO.2015.62.4544
10.1038/ng.585
10.1038/ng.3865
10.1007/s13277-014-1821-4
10.1038/nature10509
10.1038/ng.2803
10.1038/s41467-019-10637-8
10.1038/nature14962
10.1016/j.bcmd.2015.11.006
10.1038/ng.3643
10.1038/nature14248
10.1016/j.ajhg.2017.04.013
10.1111/bjh.12069
10.1101/gr.094052.109
10.1038/nmeth.2688
10.1038/nature05690
10.1056/NEJMsa0708739
10.1038/374733a0
10.1093/acprof:oso/9780198520702.001.0001
10.1038/ng.430
10.1182/blood-2016-03-704973
10.1093/annonc/mdv540
10.1038/nature15393
10.1038/ng.2394
10.1038/ng.3538
10.1038/nature05911
10.1038/s41467-018-03178-z
10.1016/j.mce.2010.04.005
10.1371/journal.pgen.1007889
10.1038/nature11247
10.1038/nprot.2010.116
10.1038/srep15065
10.1016/j.cell.2016.09.037
10.1182/blood-2013-03-491316
10.1016/j.ajhg.2016.12.008
10.1038/ng.2416
10.1101/gad.1567107
10.1182/blood-2008-01-132837
10.1182/blood-2014-09-595744
10.1056/NEJMoa0900386
10.1086/519795
10.1038/ng.3656
10.1182/blood-2012-07-440107
10.1158/1055-9965.EPI-18-0801
10.1038/leu.2017.24
10.1126/science.8438156
10.1038/ng.2756
10.1093/oxfordjournals.bmb.a011577
10.1126/science.1262110
10.1038/ng2088
10.1038/leu.2016.271
10.1038/nrc1164
10.1038/ng.432
10.1007/978-1-62703-447-0_9
10.1038/nmeth.1785
10.1371/journal.pbio.1001046
10.1186/s13045-018-0628-y
10.1038/s41467-017-02317-2
10.1186/s13059-016-0992-2
10.1016/j.cell.2014.11.021
10.1038/ng.3691
10.1093/jnci/djt042
10.1038/ng.572
10.1371/journal.pgen.1002003
10.1038/nrg2796
ContentType Journal Article
Copyright The Author(s) 2019
2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2019
– notice: 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-019-13069-6
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
ProQuest Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Proquest Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Medical Database
Biological Science Database
Advanced Technologies & Aerospace Database
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Open Access Full Text
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE
MEDLINE - Academic
Publicly Available Content Database



CrossRef
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 9
ExternalDocumentID oai_doaj_org_article_fe499f58e3cb45709aa02c81074cf619
PMC6877561
31767839
10_1038_s41467_019_13069_6
Genre Meta-Analysis
Research Support, Non-U.S. Gov't
Journal Article
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: U.S. Department of Health & Human Services | National Institutes of Health (NIH)
  grantid: CA176063, GM115279
  funderid: https://doi.org/10.13039/100000002
– fundername: NCI NIH HHS
  grantid: U10 CA098413
– fundername: NCI NIH HHS
  grantid: U24 CA114766
– fundername: NCI NIH HHS
  grantid: U10 CA180886
– fundername: NCI NIH HHS
  grantid: U01 CA176063
– fundername: NIGMS NIH HHS
  grantid: U01 GM092666
– fundername: NIGMS NIH HHS
  grantid: U01 GM097119
– fundername: NCI NIH HHS
  grantid: P30 CA021765
– fundername: NCI NIH HHS
  grantid: U10 CA180899
– fundername: NIGMS NIH HHS
  grantid: P50 GM115279
– fundername: Medical Research Council
  grantid: MC_PC_19009
– fundername: ;
  grantid: CA176063, GM115279
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
PQGLB
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c540t-5d7b0f2ef47e1a12c8f8ec521684b130e4bf3b4cd72eaa9134bca0b6c501cedd3
IEDL.DBID C6C
ISSN 2041-1723
IngestDate Wed Aug 27 01:31:08 EDT 2025
Thu Aug 21 14:09:33 EDT 2025
Fri Jul 11 07:39:59 EDT 2025
Wed Aug 13 04:03:35 EDT 2025
Mon Jul 21 05:43:24 EDT 2025
Tue Jul 01 04:08:47 EDT 2025
Thu Apr 24 23:03:38 EDT 2025
Fri Feb 21 02:38:48 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-5d7b0f2ef47e1a12c8f8ec521684b130e4bf3b4cd72eaa9134bca0b6c501cedd3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0002-9333-5322
0000-0002-7157-754X
0000-0002-5938-5510
0000-0002-0770-9659
0000-0003-1783-6296
0000-0002-1871-1850
0000-0002-8284-2249
0000-0002-8348-5829
0000-0002-5268-0242
0000-0003-0303-5658
0000-0001-9663-4611
OpenAccessLink https://www.nature.com/articles/s41467-019-13069-6
PMID 31767839
PQID 2317938629
PQPubID 546298
PageCount 9
ParticipantIDs doaj_primary_oai_doaj_org_article_fe499f58e3cb45709aa02c81074cf619
pubmedcentral_primary_oai_pubmedcentral_nih_gov_6877561
proquest_miscellaneous_2318731759
proquest_journals_2317938629
pubmed_primary_31767839
crossref_citationtrail_10_1038_s41467_019_13069_6
crossref_primary_10_1038_s41467_019_13069_6
springer_journals_10_1038_s41467_019_13069_6
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2019-11-25
PublicationDateYYYYMMDD 2019-11-25
PublicationDate_xml – month: 11
  year: 2019
  text: 2019-11-25
  day: 25
PublicationDecade 2010
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2019
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References ConsortiumEPAn integrated encyclopedia of DNA elements in the human genomeNature2012489577410.1038/nature112472012Natur.489...57T1:CAS:528:DC%2BC38XhtlGnsbzN
HannonEWeedonMBrayNO’DonovanMMillJPleiotropic effects of trait-associated genetic variation on DNA methylation: utility for refining GWAS lociAm. J. Hum. Genet.201710095495910.1016/j.ajhg.2017.04.0131:CAS:528:DC%2BC2sXotVCgtrc%3D285288685473725
ZhuZIntegration of summary data from GWAS and eQTL studies predicts complex trait gene targetsNat. Genet.20164848148710.1038/ng.35381:CAS:528:DC%2BC28XkvFGrs7g%3D27019110
KharazmiEFamilial risks for childhood acute lymphocytic leukaemia in Sweden and Finland: far exceeding the effects of known germline variantsBr. J. Haematol.201215958558823025517
Roadmap EpigenomicsCIntegrative analysis of 111 reference human epigenomesNature201551831733010.1038/nature142481:CAS:528:DC%2BC2MXjtVSktbc%3D
JavierreBMLineage-specific genome architecture links enhancers and non-coding disease variants to target gene promotersCell201616713691384 e1910.1016/j.cell.2016.09.0371:CAS:528:DC%2BC28XhvFWgu7rM278632495123897
Qian, M. et al. Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics. Blood133, 724–729 (2018).
BorowitzMJClinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children’s Oncology Group studyBlood20081115477548510.1182/blood-2008-01-1328371:CAS:528:DC%2BD1cXnsVOkt74%3D183881782424148
VijayakrishnanJThe 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2ASci. Rep.2015510.1038/srep150652015NatSR...515065V1:CAS:528:DC%2BC2MXhs1KksL7N264636724604478
LarsenECDexamethasone and high-dose methotrexate improve outcome for children and young adults with high-risk B-acute lymphoblastic leukemia: a report from Children’s Oncology Group Study AALL0232J. Clin. Oncol.2016342380238810.1200/JCO.2015.62.45441:CAS:528:DC%2BC2sXhsFGmtr3M271145874981974
AnderssonAMolecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulationsProc. Natl Acad. Sci. USA2005102190691907410.1073/pnas.05066371022005PNAS..10219069A1:CAS:528:DC%2BD28XivV2htw%3D%3D163548391323166
VijayakrishnanJA genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1Leukemia20173157357910.1038/leu.2016.2711:CAS:528:DC%2BC28XhvVKgtr7K27694927
SpeedDReevaluation of SNP heritability in complex human traitsNat. Genet.20174998699210.1038/ng.38651:CAS:528:DC%2BC2sXotVOksrw%3D285306755493198
LiuJZMeta-analysis and imputation refines the association of 15q25 with smoking quantityNat. Genet.20104243644010.1038/ng.5721:CAS:528:DC%2BC3cXltFKlsro%3D204188893612983
ConsortiumEPA user’s guide to the encyclopedia of DNA elements (ENCODE)PLoS Biol.20119e100104610.1371/journal.pbio.10010461:CAS:528:DC%2BC3MXlt12hsLw%3D
PereraFPEnvironment and cancer: who are susceptible?Science19972781068107310.1126/science.278.5340.10681997Sci...278.1068P1:CAS:528:DyaK2sXnt1Wisbs%3D9353182
GruhnBPrenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidyLeukemia2008221692169710.1038/leu.2008.1521:STN:280:DC%2BD1crpt1aqsQ%3D%3D18548099
MarchiniJHowieBMyersSMcVeanGDonnellyPA new multipoint method for genome-wide association studies by imputation of genotypesNat. Genet.20073990691310.1038/ng20881:CAS:528:DC%2BD2sXmvFKlsLY%3D17572673
StoskusMVaitkevicieneGEidukaiteAGriskeviciusLETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemiaBlood Cells Mol. Dis.201657303410.1016/j.bcmd.2015.11.0061:CAS:528:DC%2BC2MXhvFGisLfM26852652
RoeJSMercanFRiveraKPappinDJVakocCRBET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemiaMol. Cell2015581028103910.1016/j.molcel.2015.04.0111:CAS:528:DC%2BC2MXosVaqsbc%3D259821144475489
HuangXInsulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancerJ. Hematol. Oncol.2018118810.1186/s13045-018-0628-y1:CAS:528:DC%2BC1MXjtVyqtL8%3D299544066025799
DawsonMAInhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemiaNature201147852953310.1038/nature105092011Natur.478..529D1:CAS:528:DC%2BC3MXht1GqsL%2FO219643403679520
ConsortiumGTThe Genotype-Tissue Expression (GTEx) projectNat. Genet.20134558058510.1038/ng.26531:CAS:528:DC%2BC3sXotlGls74%3D
MiglioriniGVariation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotypeBlood20131223298330710.1182/blood-2013-03-4913161:CAS:528:DC%2BC3sXhslyqtL7E23996088
Perez-AndreuVA genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adultsBlood201512568068610.1182/blood-2014-09-5957441:CAS:528:DC%2BC2MXis12ksL0%3D254685674304112
StillerCChildhood Cancer in Britain: Incidence, Survival, Mortality2007OxfordOxford Univ. Press10.1093/acprof:oso/9780198520702.001.0001
BarbeiraANIntegrating predicted transcriptome from multiple tissues improves association detectionPLoS Genet.201915e100788910.1371/journal.pgen.10078891:CAS:528:DC%2BC1MXosFersbw%3D306685706358100
ZhangJDeregulation of DUX4 and ERG in acute lymphoblastic leukemiaNat. Genet.2016481481148910.1038/ng.36911:CAS:528:DC%2BC28XhslehurnM277761155144107
Qian, M. et al. Genome-wide association study of susceptibility loci for T-cell acute lymphoblastic leukemia in children. J. Natl Cancer Inst. djz043 (2019).
BernsteinBEThe NIH roadmap epigenomics mapping consortiumNat. Biotechnol.2010281045104810.1038/nbt1010-10451:CAS:528:DC%2BC3cXht1yjs7nJ209445953607281
ConsortiumGTHuman genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humansScience201534864866010.1126/science.12621101:CAS:528:DC%2BC2MXnslGjtbY%3D
BuenrostroJDGiresiPGZabaLCChangHYGreenleafWJTransposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome positionNat. Methods2013101213121810.1038/nmeth.26881:CAS:528:DC%2BC3sXhsFOiu7jO240972673959825
VijayakrishnanJGenome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemiaNat. Commun.2018910.1038/s41467-018-03178-z2018NatCo...9.1340V1:CAS:528:DC%2BC1cXhtFaqsLfK296322995890276
PriceALPrincipal components analysis corrects for stratification in genome-wide association studiesNat. Genet.20063890490910.1038/ng18471:CAS:528:DC%2BD28XnsVCgsrg%3D16862161
QianMNovel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in HispanicsBlood201913372472910.1182/blood-2018-07-8629461:CAS:528:DC%2BC1MXos1Wktrs%3D305100826376278
ChenJmiR-125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1Tumour Biol.2014356293630210.1007/s13277-014-1821-41:CAS:528:DC%2BC2cXht1egurnN24643683
ZuberJRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiaNature201147852452810.1038/nature103342011Natur.478..524Z1:CAS:528:DC%2BC3MXhtFers7%2FP218142003328300
KruthKASuppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemiaBlood20171293000300810.1182/blood-2017-02-7662041:CAS:528:DC%2BC2sXht1art7rJ284241655454339
DelaneauOMarchiniJZaguryJFA linear complexity phasing method for thousands of genomesNat. Methods2011917918110.1038/nmeth.17851:CAS:528:DC%2BC3MXhsFGkurzE22138821
PurcellSPLINK: a tool set for whole-genome association and population-based linkage analysesAm. J. Hum. Genet.20078155957510.1086/5197951:CAS:528:DC%2BD2sXhtVSqurrL177019011950838
McCarthySA reference panel of 64,976 haplotypes for genotype imputationNat. Genet.2016481279128310.1038/ng.36431:CAS:528:DC%2BC28Xhtlykt7zO275483125388176
LeuJIGeorgeDLHepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondriaGenes Dev.2007213095310910.1101/gad.15671071:CAS:528:DC%2BD2sXhsVaht7vI180564232081976
IrvingJAIntegration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemiaBlood201612891192210.1182/blood-2016-03-7049731:CAS:528:DC%2BC28XhslOkt7jJ272290055026463
CoutinhoAEChapmanKEThe anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insightsMol. Cell Endocrinol.201133521310.1016/j.mce.2010.04.0051:CAS:528:DC%2BC3MXit1Ghu7c%3D203987323047790
Perez-AndreuVInherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapseNat. Genet.2013451494149810.1038/ng.28031:CAS:528:DC%2BC3sXhs1CiurjO241413644039076
Williams, L. A., Yang, J. J., Hirsch, B. A., Marcotte, E. L. & Spector, L. G. Is there etiologic heterogeneity between subtypes of childhood acute lymphoblastic leukemia? A review of variation in risk by subtype. Cancer Epidemiol. Biomarkers Prev.28, cebp.0801.2018 (2019).
WillmanCLDeletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasiaScience199325996897110.1126/science.84381561993Sci...259..968W1:CAS:528:DyaK3sXhsVWjt74%3D8438156
YangJLeeSHGoddardMEVisscherPMGenome-wide complex trait analysis (GCTA): methods, data analyses, and interpretationsMethods Mol. Biol.2013101921523610.1007/978-1-62703-447-0_91:CAS:528:DC%2BC2MXjsVOjtLs%3D23756893
WestraHJSystematic identification of trans eQTLs as putative drivers of known disease associationsNat. Genet.2013451238124310.1038/ng.27561:CAS:528:DC%2BC3sXhtl2ksLzK240136393991562
Wellcome Trust Case Control, C.Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature200744766167810.1038/nature059111:CAS:528:DC%2BD2sXmtFelsb0%3D
PuiCHTreating childhood acute lymphoblastic leukemia without cranial irradiationN. En
AE Coutinho (13069_CR52) 2011; 335
GT Consortium (13069_CR71) 2013; 45
KA Kruth (13069_CR53) 2017; 129
13069_CR44
MF Greaves (13069_CR2) 2003; 3
JS Roe (13069_CR49) 2015; 58
AC Nica (13069_CR70) 2011; 7
J Vijayakrishnan (13069_CR12) 2018; 9
JI Leu (13069_CR39) 2007; 21
D Speed (13069_CR35) 2017; 49
B Gruhn (13069_CR3) 2008; 22
J Vijayakrishnan (13069_CR11) 2017; 31
CL Willman (13069_CR46) 1993; 259
E Hannon (13069_CR72) 2017; 100
AN Barbeira (13069_CR32) 2019; 15
MJ Borowitz (13069_CR55) 2008; 111
O Delaneau (13069_CR68) 2011; 9
BE Bernstein (13069_CR23) 2010; 28
JA Irving (13069_CR48) 2016; 128
AL Price (13069_CR64) 2006; 38
R Cowper-Sal lari (13069_CR33) 2012; 44
J Zuber (13069_CR51) 2011; 478
G Migliorini (13069_CR9) 2013; 122
CH Pui (13069_CR57) 2009; 360
SS Rao (13069_CR78) 2014; 159
UK Consortium (13069_CR62) 2015; 526
CA Stiller (13069_CR5) 1996; 52
J Yang (13069_CR74) 2013; 1019
HJ Westra (13069_CR29) 2013; 45
JZ Liu (13069_CR21) 2010; 42
J Boultwood (13069_CR47) 1993; 82
MA Dawson (13069_CR50) 2011; 478
EP Consortium (13069_CR24) 2012; 489
J Cairns (13069_CR77) 2016; 17
M Qian (13069_CR14) 2019; 133
RDC Team (13069_CR58) 2008
J Zhang (13069_CR45) 2016; 48
PD Pharoah (13069_CR79) 2008; 358
Wellcome Trust Case Control, C. (13069_CR81) 2007; 447
JJ Yang (13069_CR20) 2012; 120
MJ Frampton (13069_CR36) 2016; 27
H Xu (13069_CR16) 2013; 105
E Grundberg (13069_CR30) 2012; 44
FP Perera (13069_CR4) 1997; 278
EP Consortium (13069_CR25) 2011; 9
E Papaemmanuil (13069_CR7) 2009; 41
S Purcell (13069_CR59) 2007; 81
M Stoskus (13069_CR42) 2016; 57
GT Consortium (13069_CR28) 2015; 348
DH Alexander (13069_CR65) 2009; 19
J Vijayakrishnan (13069_CR10) 2015; 5
V Perez-Andreu (13069_CR18) 2013; 45
E Kharazmi (13069_CR80) 2012; 159
C Roadmap Epigenomics (13069_CR76) 2015; 518
CA Anderson (13069_CR61) 2010; 5
JD Buenrostro (13069_CR75) 2013; 10
T Chittenden (13069_CR38) 1995; 374
13069_CR15
C Genomes Project (13069_CR63) 2015; 526
S Das (13069_CR67) 2016; 48
V Perez-Andreu (13069_CR19) 2015; 125
AL Sherborne (13069_CR8) 2010; 42
L Tian (13069_CR27) 2019; 10
CH Pui (13069_CR56) 2004; 104
S McCarthy (13069_CR66) 2016; 48
C Stiller (13069_CR1) 2007
SE Karol (13069_CR34) 2017; 31
J Chen (13069_CR40) 2014; 35
13069_CR6
J Marchini (13069_CR22) 2007; 39
Z Zhu (13069_CR73) 2018; 9
Z Zhu (13069_CR69) 2016; 48
O Takeuchi (13069_CR37) 2005; 102
LR Trevino (13069_CR13) 2009; 41
J Marchini (13069_CR60) 2010; 11
BM Javierre (13069_CR26) 2016; 167
LR Lloyd-Jones (13069_CR31) 2017; 100
EC Larsen (13069_CR54) 2016; 34
X Huang (13069_CR43) 2018; 11
CG Mullighan (13069_CR17) 2007; 446
A Andersson (13069_CR41) 2005; 102
References_xml – reference: ConsortiumGTHuman genomics. The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humansScience201534864866010.1126/science.12621101:CAS:528:DC%2BC2MXnslGjtbY%3D
– reference: MarchiniJHowieBGenotype imputation for genome-wide association studiesNat. Rev. Genet.20101149951110.1038/nrg27961:CAS:528:DC%2BC3cXovVekurs%3D20517342
– reference: MullighanCGGenome-wide analysis of genetic alterations in acute lymphoblastic leukaemiaNature200744675876410.1038/nature056902007Natur.446..758M1:CAS:528:DC%2BD2sXktVeqt7g%3D17344859
– reference: Wellcome Trust Case Control, C.Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controlsNature200744766167810.1038/nature059111:CAS:528:DC%2BD2sXmtFelsb0%3D
– reference: GreavesMFWiemelsJOrigins of chromosome translocations in childhood leukaemiaNat. Rev. Cancer2003363964910.1038/nrc11641:CAS:528:DC%2BD3sXmvVWlurc%3D12951583
– reference: VijayakrishnanJA genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1Leukemia20173157357910.1038/leu.2016.2711:CAS:528:DC%2BC28XhvVKgtr7K27694927
– reference: BorowitzMJClinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children’s Oncology Group studyBlood20081115477548510.1182/blood-2008-01-1328371:CAS:528:DC%2BD1cXnsVOkt74%3D183881782424148
– reference: WestraHJSystematic identification of trans eQTLs as putative drivers of known disease associationsNat. Genet.2013451238124310.1038/ng.27561:CAS:528:DC%2BC3sXhtl2ksLzK240136393991562
– reference: HuangXInsulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancerJ. Hematol. Oncol.2018118810.1186/s13045-018-0628-y1:CAS:528:DC%2BC1MXjtVyqtL8%3D299544066025799
– reference: VijayakrishnanJThe 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2ASci. Rep.2015510.1038/srep150652015NatSR...515065V1:CAS:528:DC%2BC2MXhs1KksL7N264636724604478
– reference: LeuJIGeorgeDLHepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondriaGenes Dev.2007213095310910.1101/gad.15671071:CAS:528:DC%2BD2sXhsVaht7vI180564232081976
– reference: ZhuZIntegration of summary data from GWAS and eQTL studies predicts complex trait gene targetsNat. Genet.20164848148710.1038/ng.35381:CAS:528:DC%2BC28XkvFGrs7g%3D27019110
– reference: YangJLeeSHGoddardMEVisscherPMGenome-wide complex trait analysis (GCTA): methods, data analyses, and interpretationsMethods Mol. Biol.2013101921523610.1007/978-1-62703-447-0_91:CAS:528:DC%2BC2MXjsVOjtLs%3D23756893
– reference: NicaACThe architecture of gene regulatory variation across multiple human tissues: the MuTHER studyPLoS Genet.20117e100200310.1371/journal.pgen.10020031:CAS:528:DC%2BC3MXitV2rsbs%3D213048903033383
– reference: ZhuZCausal associations between risk factors and common diseases inferred from GWAS summary dataNat. Commun.2018910.1038/s41467-017-02317-22018NatCo...9..224Z1:CAS:528:DC%2BC1cXhtFSltb3F293354005768719
– reference: QianMNovel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in HispanicsBlood201913372472910.1182/blood-2018-07-8629461:CAS:528:DC%2BC1MXos1Wktrs%3D305100826376278
– reference: AlexanderDHNovembreJLangeKFast model-based estimation of ancestry in unrelated individualsGenome Res.2009191655166410.1101/gr.094052.1091:CAS:528:DC%2BD1MXhtFCjsLvL196482172752134
– reference: McCarthySA reference panel of 64,976 haplotypes for genotype imputationNat. Genet.2016481279128310.1038/ng.36431:CAS:528:DC%2BC28Xhtlykt7zO275483125388176
– reference: CairnsJCHiCAGO: robust detection of DNA looping interactions in Capture Hi-C dataGenome Biol.20161710.1186/s13059-016-0992-21:CAS:528:DC%2BC2sXns1egtbs%3D273068824908757
– reference: PriceALPrincipal components analysis corrects for stratification in genome-wide association studiesNat. Genet.20063890490910.1038/ng18471:CAS:528:DC%2BD28XnsVCgsrg%3D16862161
– reference: DelaneauOMarchiniJZaguryJFA linear complexity phasing method for thousands of genomesNat. Methods2011917918110.1038/nmeth.17851:CAS:528:DC%2BC3MXhsFGkurzE22138821
– reference: StillerCAParkinDMGeographic and ethnic variations in the incidence of childhood cancerBr. Med. Bull.19965268270310.1093/oxfordjournals.bmb.a0115771:STN:280:DyaK2s7ptFOrtg%3D%3D9039726
– reference: FramptonMJImplications of polygenic risk for personalised colorectal cancer screeningAnn. Oncol.20162742943410.1093/annonc/mdv5401:STN:280:DC%2BC28vislGgsA%3D%3D26578737
– reference: IrvingJAIntegration of genetic and clinical risk factors improves prognostication in relapsed childhood B-cell precursor acute lymphoblastic leukemiaBlood201612891192210.1182/blood-2016-03-7049731:CAS:528:DC%2BC28XhslOkt7jJ272290055026463
– reference: RoeJSMercanFRiveraKPappinDJVakocCRBET bromodomain inhibition suppresses the function of hematopoietic transcription factors in acute myeloid leukemiaMol. Cell2015581028103910.1016/j.molcel.2015.04.0111:CAS:528:DC%2BC2MXosVaqsbc%3D259821144475489
– reference: YangJJGenome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemiaBlood20121204197420410.1182/blood-2012-07-4401071:CAS:528:DC%2BC38XhslKmu7nF230074063501717
– reference: PurcellSPLINK: a tool set for whole-genome association and population-based linkage analysesAm. J. Hum. Genet.20078155957510.1086/5197951:CAS:528:DC%2BD2sXhtVSqurrL177019011950838
– reference: TeamRDCR: A Language and Environment for Statistical Computing.2008Vienna, AustriaR Foundation for Statistical Computing
– reference: VijayakrishnanJGenome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemiaNat. Commun.2018910.1038/s41467-018-03178-z2018NatCo...9.1340V1:CAS:528:DC%2BC1cXhtFaqsLfK296322995890276
– reference: ConsortiumEPAn integrated encyclopedia of DNA elements in the human genomeNature2012489577410.1038/nature112472012Natur.489...57T1:CAS:528:DC%2BC38XhtlGnsbzN
– reference: GrundbergEMapping cis- and trans-regulatory effects across multiple tissues in twinsNat. Genet.2012441084108910.1038/ng.23941:CAS:528:DC%2BC38Xht12js7nF229411923784328
– reference: RaoSSA 3D map of the human genome at kilobase resolution reveals principles of chromatin loopingCell20141591665168010.1016/j.cell.2014.11.0211:CAS:528:DC%2BC2cXitFCrtrrK254975475635824
– reference: Genomes ProjectCA global reference for human genetic variationNature2015526687410.1038/nature153932015Natur.526...68T1:CAS:528:DC%2BC2MXhs1SitLjO
– reference: DawsonMAInhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemiaNature201147852953310.1038/nature105092011Natur.478..529D1:CAS:528:DC%2BC3MXht1GqsL%2FO219643403679520
– reference: PuiCHTreating childhood acute lymphoblastic leukemia without cranial irradiationN. Engl. J. Med20093602730274110.1056/NEJMoa09003861:CAS:528:DC%2BD1MXns1eit78%3D195536472754320
– reference: ConsortiumGTThe Genotype-Tissue Expression (GTEx) projectNat. Genet.20134558058510.1038/ng.26531:CAS:528:DC%2BC3sXotlGls74%3D
– reference: Perez-AndreuVA genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adultsBlood201512568068610.1182/blood-2014-09-5957441:CAS:528:DC%2BC2MXis12ksL0%3D254685674304112
– reference: SherborneALVariation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia riskNat. Genet.20104249249410.1038/ng.5851:CAS:528:DC%2BC3cXlslyqsL4%3D204538393434228
– reference: PereraFPEnvironment and cancer: who are susceptible?Science19972781068107310.1126/science.278.5340.10681997Sci...278.1068P1:CAS:528:DyaK2sXnt1Wisbs%3D9353182
– reference: ConsortiumEPA user’s guide to the encyclopedia of DNA elements (ENCODE)PLoS Biol.20119e100104610.1371/journal.pbio.10010461:CAS:528:DC%2BC3MXlt12hsLw%3D
– reference: KarolSEGenetics of ancestry-specific risk for relapse in acute lymphoblastic leukemiaLeukemia2017311325133210.1038/leu.2017.241:CAS:528:DC%2BC2sXisVymtbo%3D280965355462853
– reference: JavierreBMLineage-specific genome architecture links enhancers and non-coding disease variants to target gene promotersCell201616713691384 e1910.1016/j.cell.2016.09.0371:CAS:528:DC%2BC28XhvFWgu7rM278632495123897
– reference: Qian, M. et al. Novel susceptibility variants at the ERG locus for childhood acute lymphoblastic leukemia in Hispanics. Blood133, 724–729 (2018).
– reference: TrevinoLRGermline genomic variants associated with childhood acute lymphoblastic leukemiaNat. Genet.2009411001100510.1038/ng.4321:CAS:528:DC%2BD1MXpvFCrsrs%3D196846032762391
– reference: Perez-AndreuVInherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapseNat. Genet.2013451494149810.1038/ng.28031:CAS:528:DC%2BC3sXhs1CiurjO241413644039076
– reference: AndersonCAData quality control in genetic case-control association studiesNat. Protoc.201051564157310.1038/nprot.2010.1161:CAS:528:DC%2BC3cXht1aksLvN210851223025522
– reference: DasSNext-generation genotype imputation service and methodsNat. Genet.2016481284128710.1038/ng.36561:CAS:528:DC%2BC28XhsVWksL%2FK275712635157836
– reference: KharazmiEFamilial risks for childhood acute lymphocytic leukaemia in Sweden and Finland: far exceeding the effects of known germline variantsBr. J. Haematol.201215958558823025517
– reference: ChittendenTInduction of apoptosis by the Bcl-2 homologue BakNature199537473373610.1038/374733a01995Natur.374..733C1:CAS:528:DyaK2MXlt12nsb4%3D7715730
– reference: ChenJmiR-125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1Tumour Biol.2014356293630210.1007/s13277-014-1821-41:CAS:528:DC%2BC2cXht1egurnN24643683
– reference: MiglioriniGVariation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotypeBlood20131223298330710.1182/blood-2013-03-4913161:CAS:528:DC%2BC3sXhslyqtL7E23996088
– reference: MarchiniJHowieBMyersSMcVeanGDonnellyPA new multipoint method for genome-wide association studies by imputation of genotypesNat. Genet.20073990691310.1038/ng20881:CAS:528:DC%2BD2sXmvFKlsLY%3D17572673
– reference: SpeedDReevaluation of SNP heritability in complex human traitsNat. Genet.20174998699210.1038/ng.38651:CAS:528:DC%2BC2sXotVOksrw%3D285306755493198
– reference: TakeuchiOEssential role of BAX,BAK in B cell homeostasis and prevention of autoimmune diseaseProc. Natl Acad. Sci. USA2005102112721127710.1073/pnas.05047831022005PNAS..10211272T1:CAS:528:DC%2BD2MXoslKitrc%3D160555541183578
– reference: TianLLong-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemiaNat. Commun.20191010.1038/s41467-019-10637-82019NatCo..10.2789T1:CAS:528:DC%2BC1MXhtlWisbzE312432746594946
– reference: PharoahPDAntoniouACEastonDFPonderBAPolygenes, risk prediction, and targeted prevention of breast cancerN. Engl. J. Med.20083582796280310.1056/NEJMsa07087391:CAS:528:DC%2BD1cXnvFamt7Y%3D18579814
– reference: PapaemmanuilELoci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemiaNat. Genet.2009411006101010.1038/ng.4301:CAS:528:DC%2BD1MXpvFCru78%3D196846044915548
– reference: HannonEWeedonMBrayNO’DonovanMMillJPleiotropic effects of trait-associated genetic variation on DNA methylation: utility for refining GWAS lociAm. J. Hum. Genet.201710095495910.1016/j.ajhg.2017.04.0131:CAS:528:DC%2BC2sXotVCgtrc%3D285288685473725
– reference: ConsortiumUKThe UK10K project identifies rare variants in health and diseaseNature2015526829010.1038/nature149622015Natur.526...82T1:CAS:528:DC%2BC2MXhsFeiu7fI
– reference: WillmanCLDeletion of IRF-1, mapping to chromosome 5q31.1, in human leukemia and preleukemic myelodysplasiaScience199325996897110.1126/science.84381561993Sci...259..968W1:CAS:528:DyaK3sXhsVWjt74%3D8438156
– reference: StoskusMVaitkevicieneGEidukaiteAGriskeviciusLETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemiaBlood Cells Mol. Dis.201657303410.1016/j.bcmd.2015.11.0061:CAS:528:DC%2BC2MXhvFGisLfM26852652
– reference: Qian, M. et al. Genome-wide association study of susceptibility loci for T-cell acute lymphoblastic leukemia in children. J. Natl Cancer Inst. djz043 (2019).
– reference: KruthKASuppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemiaBlood20171293000300810.1182/blood-2017-02-7662041:CAS:528:DC%2BC2sXht1art7rJ284241655454339
– reference: LiuJZMeta-analysis and imputation refines the association of 15q25 with smoking quantityNat. Genet.20104243644010.1038/ng.5721:CAS:528:DC%2BC3cXltFKlsro%3D204188893612983
– reference: LarsenECDexamethasone and high-dose methotrexate improve outcome for children and young adults with high-risk B-acute lymphoblastic leukemia: a report from Children’s Oncology Group Study AALL0232J. Clin. Oncol.2016342380238810.1200/JCO.2015.62.45441:CAS:528:DC%2BC2sXhsFGmtr3M271145874981974
– reference: StillerCChildhood Cancer in Britain: Incidence, Survival, Mortality2007OxfordOxford Univ. Press10.1093/acprof:oso/9780198520702.001.0001
– reference: PuiCHImproved outcome for children with acute lymphoblastic leukemia: results of Total Therapy Study XIIIB at St Jude Children’s Research HospitalBlood20041042690269610.1182/blood-2004-04-16161:CAS:528:DC%2BD2cXpslKjsLc%3D15251979
– reference: BarbeiraANIntegrating predicted transcriptome from multiple tissues improves association detectionPLoS Genet.201915e100788910.1371/journal.pgen.10078891:CAS:528:DC%2BC1MXosFersbw%3D306685706358100
– reference: AnderssonAMolecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulationsProc. Natl Acad. Sci. USA2005102190691907410.1073/pnas.05066371022005PNAS..10219069A1:CAS:528:DC%2BD28XivV2htw%3D%3D163548391323166
– reference: CoutinhoAEChapmanKEThe anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insightsMol. Cell Endocrinol.201133521310.1016/j.mce.2010.04.0051:CAS:528:DC%2BC3MXit1Ghu7c%3D203987323047790
– reference: BernsteinBEThe NIH roadmap epigenomics mapping consortiumNat. Biotechnol.2010281045104810.1038/nbt1010-10451:CAS:528:DC%2BC3cXht1yjs7nJ209445953607281
– reference: BuenrostroJDGiresiPGZabaLCChangHYGreenleafWJTransposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome positionNat. Methods2013101213121810.1038/nmeth.26881:CAS:528:DC%2BC3sXhsFOiu7jO240972673959825
– reference: Lloyd-JonesLRThe genetic architecture of gene expression in peripheral bloodAm. J. Hum. Genet.201710022823710.1016/j.ajhg.2016.12.0081:CAS:528:DC%2BC2sXlt12qsQ%3D%3D280654685294670
– reference: Cowper-Sal lariRBreast cancer risk-associated SNPs modulate the affinity of chromatin for FOXA1 and alter gene expressionNat. Genet.2012441191119810.1038/ng.24161:CAS:528:DC%2BC38Xhtlyls7jK230011243483423
– reference: XuHNovel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populationsJ. Natl Cancer Inst.201310573374210.1093/jnci/djt0421:CAS:528:DC%2BC3sXosVensbk%3D235122503691938
– reference: Roadmap EpigenomicsCIntegrative analysis of 111 reference human epigenomesNature201551831733010.1038/nature142481:CAS:528:DC%2BC2MXjtVSktbc%3D
– reference: ZuberJRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemiaNature201147852452810.1038/nature103342011Natur.478..524Z1:CAS:528:DC%2BC3MXhtFers7%2FP218142003328300
– reference: GruhnBPrenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidyLeukemia2008221692169710.1038/leu.2008.1521:STN:280:DC%2BD1crpt1aqsQ%3D%3D18548099
– reference: BoultwoodJAllelic loss of IRF1 in myelodysplasia and acute myeloid leukemia: retention of IRF1 on the 5q- chromosome in some patients with the 5q- syndromeBlood1993822611261610.1182/blood.V82.9.2611.26111:STN:280:DyaK2c%2FjtlGntg%3D%3D8219215
– reference: Williams, L. A., Yang, J. J., Hirsch, B. A., Marcotte, E. L. & Spector, L. G. Is there etiologic heterogeneity between subtypes of childhood acute lymphoblastic leukemia? A review of variation in risk by subtype. Cancer Epidemiol. Biomarkers Prev.28, cebp.0801.2018 (2019).
– reference: ZhangJDeregulation of DUX4 and ERG in acute lymphoblastic leukemiaNat. Genet.2016481481148910.1038/ng.36911:CAS:528:DC%2BC28XhslehurnM277761155144107
– volume: 102
  start-page: 19069
  year: 2005
  ident: 13069_CR41
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0506637102
– volume: 133
  start-page: 724
  year: 2019
  ident: 13069_CR14
  publication-title: Blood
  doi: 10.1182/blood-2018-07-862946
– volume: 22
  start-page: 1692
  year: 2008
  ident: 13069_CR3
  publication-title: Leukemia
  doi: 10.1038/leu.2008.152
– volume: 28
  start-page: 1045
  year: 2010
  ident: 13069_CR23
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt1010-1045
– volume: 129
  start-page: 3000
  year: 2017
  ident: 13069_CR53
  publication-title: Blood
  doi: 10.1182/blood-2017-02-766204
– volume: 104
  start-page: 2690
  year: 2004
  ident: 13069_CR56
  publication-title: Blood
  doi: 10.1182/blood-2004-04-1616
– volume: 82
  start-page: 2611
  year: 1993
  ident: 13069_CR47
  publication-title: Blood
  doi: 10.1182/blood.V82.9.2611.2611
– volume: 38
  start-page: 904
  year: 2006
  ident: 13069_CR64
  publication-title: Nat. Genet.
  doi: 10.1038/ng1847
– volume: 278
  start-page: 1068
  year: 1997
  ident: 13069_CR4
  publication-title: Science
  doi: 10.1126/science.278.5340.1068
– volume: 45
  start-page: 580
  year: 2013
  ident: 13069_CR71
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2653
– volume: 102
  start-page: 11272
  year: 2005
  ident: 13069_CR37
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0504783102
– volume: 58
  start-page: 1028
  year: 2015
  ident: 13069_CR49
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2015.04.011
– volume: 478
  start-page: 524
  year: 2011
  ident: 13069_CR51
  publication-title: Nature
  doi: 10.1038/nature10334
– volume: 34
  start-page: 2380
  year: 2016
  ident: 13069_CR54
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2015.62.4544
– volume-title: R: A Language and Environment for Statistical Computing.
  year: 2008
  ident: 13069_CR58
– volume: 42
  start-page: 492
  year: 2010
  ident: 13069_CR8
  publication-title: Nat. Genet.
  doi: 10.1038/ng.585
– volume: 49
  start-page: 986
  year: 2017
  ident: 13069_CR35
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3865
– volume: 35
  start-page: 6293
  year: 2014
  ident: 13069_CR40
  publication-title: Tumour Biol.
  doi: 10.1007/s13277-014-1821-4
– volume: 478
  start-page: 529
  year: 2011
  ident: 13069_CR50
  publication-title: Nature
  doi: 10.1038/nature10509
– volume: 45
  start-page: 1494
  year: 2013
  ident: 13069_CR18
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2803
– volume: 10
  year: 2019
  ident: 13069_CR27
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10637-8
– volume: 526
  start-page: 82
  year: 2015
  ident: 13069_CR62
  publication-title: Nature
  doi: 10.1038/nature14962
– volume: 57
  start-page: 30
  year: 2016
  ident: 13069_CR42
  publication-title: Blood Cells Mol. Dis.
  doi: 10.1016/j.bcmd.2015.11.006
– volume: 48
  start-page: 1279
  year: 2016
  ident: 13069_CR66
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3643
– volume: 518
  start-page: 317
  year: 2015
  ident: 13069_CR76
  publication-title: Nature
  doi: 10.1038/nature14248
– volume: 100
  start-page: 954
  year: 2017
  ident: 13069_CR72
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2017.04.013
– volume: 159
  start-page: 585
  year: 2012
  ident: 13069_CR80
  publication-title: Br. J. Haematol.
  doi: 10.1111/bjh.12069
– volume: 19
  start-page: 1655
  year: 2009
  ident: 13069_CR65
  publication-title: Genome Res.
  doi: 10.1101/gr.094052.109
– volume: 10
  start-page: 1213
  year: 2013
  ident: 13069_CR75
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2688
– volume: 446
  start-page: 758
  year: 2007
  ident: 13069_CR17
  publication-title: Nature
  doi: 10.1038/nature05690
– volume: 358
  start-page: 2796
  year: 2008
  ident: 13069_CR79
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMsa0708739
– volume: 374
  start-page: 733
  year: 1995
  ident: 13069_CR38
  publication-title: Nature
  doi: 10.1038/374733a0
– volume-title: Childhood Cancer in Britain: Incidence, Survival, Mortality
  year: 2007
  ident: 13069_CR1
  doi: 10.1093/acprof:oso/9780198520702.001.0001
– volume: 41
  start-page: 1006
  year: 2009
  ident: 13069_CR7
  publication-title: Nat. Genet.
  doi: 10.1038/ng.430
– volume: 128
  start-page: 911
  year: 2016
  ident: 13069_CR48
  publication-title: Blood
  doi: 10.1182/blood-2016-03-704973
– volume: 27
  start-page: 429
  year: 2016
  ident: 13069_CR36
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdv540
– volume: 526
  start-page: 68
  year: 2015
  ident: 13069_CR63
  publication-title: Nature
  doi: 10.1038/nature15393
– volume: 44
  start-page: 1084
  year: 2012
  ident: 13069_CR30
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2394
– volume: 48
  start-page: 481
  year: 2016
  ident: 13069_CR69
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3538
– volume: 447
  start-page: 661
  year: 2007
  ident: 13069_CR81
  publication-title: Nature
  doi: 10.1038/nature05911
– volume: 9
  year: 2018
  ident: 13069_CR12
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-03178-z
– volume: 335
  start-page: 2
  year: 2011
  ident: 13069_CR52
  publication-title: Mol. Cell Endocrinol.
  doi: 10.1016/j.mce.2010.04.005
– volume: 15
  start-page: e1007889
  year: 2019
  ident: 13069_CR32
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1007889
– volume: 489
  start-page: 57
  year: 2012
  ident: 13069_CR24
  publication-title: Nature
  doi: 10.1038/nature11247
– volume: 5
  start-page: 1564
  year: 2010
  ident: 13069_CR61
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2010.116
– volume: 5
  year: 2015
  ident: 13069_CR10
  publication-title: Sci. Rep.
  doi: 10.1038/srep15065
– volume: 167
  start-page: 1369
  year: 2016
  ident: 13069_CR26
  publication-title: Cell
  doi: 10.1016/j.cell.2016.09.037
– volume: 122
  start-page: 3298
  year: 2013
  ident: 13069_CR9
  publication-title: Blood
  doi: 10.1182/blood-2013-03-491316
– volume: 100
  start-page: 228
  year: 2017
  ident: 13069_CR31
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2016.12.008
– volume: 44
  start-page: 1191
  year: 2012
  ident: 13069_CR33
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2416
– volume: 21
  start-page: 3095
  year: 2007
  ident: 13069_CR39
  publication-title: Genes Dev.
  doi: 10.1101/gad.1567107
– volume: 111
  start-page: 5477
  year: 2008
  ident: 13069_CR55
  publication-title: Blood
  doi: 10.1182/blood-2008-01-132837
– volume: 125
  start-page: 680
  year: 2015
  ident: 13069_CR19
  publication-title: Blood
  doi: 10.1182/blood-2014-09-595744
– volume: 360
  start-page: 2730
  year: 2009
  ident: 13069_CR57
  publication-title: N. Engl. J. Med
  doi: 10.1056/NEJMoa0900386
– volume: 81
  start-page: 559
  year: 2007
  ident: 13069_CR59
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/519795
– volume: 48
  start-page: 1284
  year: 2016
  ident: 13069_CR67
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3656
– volume: 120
  start-page: 4197
  year: 2012
  ident: 13069_CR20
  publication-title: Blood
  doi: 10.1182/blood-2012-07-440107
– ident: 13069_CR44
  doi: 10.1182/blood-2018-07-862946
– ident: 13069_CR6
  doi: 10.1158/1055-9965.EPI-18-0801
– volume: 31
  start-page: 1325
  year: 2017
  ident: 13069_CR34
  publication-title: Leukemia
  doi: 10.1038/leu.2017.24
– volume: 259
  start-page: 968
  year: 1993
  ident: 13069_CR46
  publication-title: Science
  doi: 10.1126/science.8438156
– volume: 45
  start-page: 1238
  year: 2013
  ident: 13069_CR29
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2756
– volume: 52
  start-page: 682
  year: 1996
  ident: 13069_CR5
  publication-title: Br. Med. Bull.
  doi: 10.1093/oxfordjournals.bmb.a011577
– volume: 348
  start-page: 648
  year: 2015
  ident: 13069_CR28
  publication-title: Science
  doi: 10.1126/science.1262110
– volume: 39
  start-page: 906
  year: 2007
  ident: 13069_CR22
  publication-title: Nat. Genet.
  doi: 10.1038/ng2088
– volume: 31
  start-page: 573
  year: 2017
  ident: 13069_CR11
  publication-title: Leukemia
  doi: 10.1038/leu.2016.271
– volume: 3
  start-page: 639
  year: 2003
  ident: 13069_CR2
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1164
– volume: 41
  start-page: 1001
  year: 2009
  ident: 13069_CR13
  publication-title: Nat. Genet.
  doi: 10.1038/ng.432
– volume: 1019
  start-page: 215
  year: 2013
  ident: 13069_CR74
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-62703-447-0_9
– volume: 9
  start-page: 179
  year: 2011
  ident: 13069_CR68
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1785
– volume: 9
  start-page: e1001046
  year: 2011
  ident: 13069_CR25
  publication-title: PLoS Biol.
  doi: 10.1371/journal.pbio.1001046
– volume: 11
  start-page: 88
  year: 2018
  ident: 13069_CR43
  publication-title: J. Hematol. Oncol.
  doi: 10.1186/s13045-018-0628-y
– ident: 13069_CR15
– volume: 9
  year: 2018
  ident: 13069_CR73
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-02317-2
– volume: 17
  year: 2016
  ident: 13069_CR77
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-0992-2
– volume: 159
  start-page: 1665
  year: 2014
  ident: 13069_CR78
  publication-title: Cell
  doi: 10.1016/j.cell.2014.11.021
– volume: 48
  start-page: 1481
  year: 2016
  ident: 13069_CR45
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3691
– volume: 105
  start-page: 733
  year: 2013
  ident: 13069_CR16
  publication-title: J. Natl Cancer Inst.
  doi: 10.1093/jnci/djt042
– volume: 42
  start-page: 436
  year: 2010
  ident: 13069_CR21
  publication-title: Nat. Genet.
  doi: 10.1038/ng.572
– volume: 7
  start-page: e1002003
  year: 2011
  ident: 13069_CR70
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002003
– volume: 11
  start-page: 499
  year: 2010
  ident: 13069_CR60
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/nrg2796
SSID ssj0000391844
Score 2.5331078
SecondaryResourceType review_article
Snippet There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk...
B-cell acute lymphoblastic leukaemia (B-ALL) is a common childhood cancer. Here, the authors conducted a meta-analysis with four genome-wide association...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 5348
SubjectTerms 45
45/43
631/208/205/2138
631/67/1990/283/2125
631/67/2332
692/4028/67/1990/283/2125
Acute lymphoblastic leukemia
bcl-2 Homologous Antagonist-Killer Protein - genetics
Blood cancer
Cell cycle
Child
Chromatin
Chromosome 9
Core Binding Factor Alpha 2 Subunit - genetics
Deregulation
Epigenomics
Genetic Predisposition to Disease - genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomic analysis
Humanities and Social Sciences
Humans
Leukemia
Loci
Lymphocytes B
multidisciplinary
Oncogene Proteins, Fusion - genetics
Polymorphism, Single Nucleotide
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology
Risk
Risk Factors
RNA-Binding Proteins - genetics
Runx1 protein
Science
Science (multidisciplinary)
Transcriptome
SummonAdditionalLinks – databaseName: DOAJ Open Access Full Text
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3daxQxEA9SEHwRtX6c1hLBNw3d3Xzuo5WWIuiTxb6FJDuDxXO39O6E_vdOsnvXnh_1xddksoTfzGR-2SQzjL3WkZwmVkHUqUahOrQixBYFGqcVBAtVqQ348ZM5OVUfzvTZjVJf-U7YmB54BO4AgTg5agcyRaVt1YZQNcnle4QJTUn42VDMu7GZKmuwbGnroqZXMpV0BwtV1gRiNIKWbdMKsxWJSsL-P7HM3y9L_nJiWgLR8QN2f2KQ_N0484fsDvSP2N2xpuTVLvsyPr3F6V8cH5AjDeH98APmPFxrY0Htl_xQ5F_3PKTVEvj8inQ7RCLU9G0-h9W3AN_PA8_3zx-z0-Ojz-9PxFQ9QSRiYUuhOxsrbACVhTrUhBk6SBStjVORIAAVUUaVOttACPkAPqZQRZN0VSfoOvmE7fRDD88YT9p1oFG2MtL-S2IIhkTJ01G3Slo9Y_UaSZ-m1OK5wsXclyNu6fyIvif0fUHfmxl7sxlzMSbWuFX6MCtoI5mTYpcGMhU_mYr_l6nM2N5avX7y1IUnfktLFO3rqPvVppt8LKMfehhWRcbZTLRI5uloDZuZUDPFe0k9dstOtqa63dOffy15vI2zlujrjL1dW9T1tP4OxfP_AcULdq8prlCLRu-xneXlCl4Su1rG_eJIPwG9yyEP
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkLorwaKMhI3MBqEtuxc0IUtaqQ4ETF3izbGUPFkrT7QOq_Z-x4s1oevdrjyJmH_Xk8niHktXRoNK60rPJVYKILilnXBhYaLQVYBWWqDfjpc3N2Lj7O5Cw73JY5rHKzJqaFuht89JEfIQ5BVUL83b67vGKxalS8Xc0lNG6TOzF1WQzpUjM1-Vhi9nMtRH4rU3J9tBRpZUBcw3DxblrW7OxHKW3_v7Dm3yGTf9ybpu3o9AG5n3EkfT8Kfp_cgv4huTtWlrx-RL6OD3BD9sjRIdCAQ2g__II5tVuZLLF9QY9ZdOBT69croPNrlPDgEFbjt-kc1j8s_LywNEahPybnpydfPpyxXEOBecRiKyY75cpQQxAKKlvVXgcNHvfsRguHLADhAnfCd6oGa-M1vPO2dI2XZeWh6_gTstcPPRwQ6qXuQAbecoenMB6sbZAU7T3IVnAlC1JtOGl8TjAe61zMTbro5tqM3DfIfZO4b5qCvJnGXI7pNW6kPo4CmihjauzUMCy-mWxpJgAe4oLUwL0TUpWttSX-dgw89QGPiwU53IjXZHtdmq12FeTV1I2WFrlvexjWiUarCLeQ5umoDdNMsBl3fY49akdPdqa629NffE_ZvButFILYgrzdaNR2Wv9nxbOb_-I5uVcnJa9YLQ_J3mqxhheInlbuZTKR39CXGNI
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZKERKXivLqQouMxA0MSWzHzgEhiqgqpHJiRW-W7YyhIk3KPhD77xk7yVYLCxJXzzhy5mF_48cMIc-kQ6dxmWW5zwMTdVDMuiqwUGopwCrIUm3As4_l6VR8OJfnO2QsdzQIcL41tIv1pKaz5uXP76s36PCv-yfj-tVcJHdHsMJwRi4rVt4gN3FlUtFRzwa4n2ZmXmFAI4a3M9u7bqxPKY3_Nuz55xXK385R0_J0cofsDbiSvu0NYZ_sQHuX3OorTa7ukc_9g9ww7NDRLtCAXWjb_YCG2msdzbF9Ro9Z3NCn1i8XQJsVarxzCLPx27SB5TcLlxeWxlvp98n05P2nd6dsqKnAPGKzBZO1clkoIAgFuc0Lr4MGj2t4qYVDEYBwgTvha1WAtfFY3nmbudLLLPdQ1_wB2W27Fg4I9VLXIAOvuMOojAdrS2RF_w-yElzJCclHSRo_JByPdS8akw6-uTa99A1K3yTpm3JCnq_7XPXpNv7JfRwVtOaMqbJTQzf7YgbPMwEwqAtSA_dOSJVV1mb42_Eiqg8YPk7I4aheM5qfQdSLExdGe0h-uiaj50Xp2xa6ZeLRKsIv5HnYW8N6JNiMKIAjRW3YycZQNyntxdeU3bvUSiGonZAXo0VdD-vvonj0f-yPye0iGX3OCnlIdhezJRwhulq4J8llfgGejCAy
  priority: 102
  providerName: Scholars Portal
Title Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk
URI https://link.springer.com/article/10.1038/s41467-019-13069-6
https://www.ncbi.nlm.nih.gov/pubmed/31767839
https://www.proquest.com/docview/2317938629
https://www.proquest.com/docview/2318731759
https://pubmed.ncbi.nlm.nih.gov/PMC6877561
https://doaj.org/article/fe499f58e3cb45709aa02c81074cf619
Volume 10
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3raxQxEA99IPil-Pa0HhH8psHdzfM-3h09y0GLqMX7FpJsUovnbrmH0P_eSfZRTqvgl11IJkt2MpP5TTKZIPSGW1AamxmSuzwQVgZJjB0FEoTizBvps3Q34Nm5OL1g8wVf7KGiOwuTgvZTSss0TXfRYe_XLKk0ABICs64YEbGPDmPq9ijVUzHt11VixnPFWHs-JqPqjqY7Niil6r8LX_4ZJvnbXmkyQbMH6KjFjnjc9PYh2vPVI3SvuU3y5jH62hy6De0qHK4DDtAEV_VPv8TmdhzWUL7CExIX7bFx243HyxsY1doClIZv46Xffjf-x5XBMfL8CbqYnXyZnpL23gTiAH9tCC-lzULhA5M-N3nhVFDegZ0WillggWc2UMtcKQtvTNx6t85kVjie5c6XJX2KDqq68s8RdlyVngc6ohY8LxqMEUAKOh74iFHJByjvOKldm1Q83m2x1GlzmyrdcF8D93XivhYD9LZvc92k1Pgn9SQOUE8Z02Gngnp1qVvx0MGD4xa48tRZxmU2MiaD347Bpi6AizhAx93w6lZH1xqQLUxO4NFB9eu-GrQrct9Uvt4mGiUjxAKaZ4009D2BYrD0FGrkjpzsdHW3prr6ljJ4CyUlANcBetdJ1G23_s6KF_9H_hLdL5LQ56Tgx-hgs9r6V4CgNnaI9uVCwlPNPgzR4Xg8_zyH9-Tk_OOnYVKnYVqbgOcZU78AMCcdVg
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LjxQhECbrGqMX49vWVTHRk5LtbqChD8a46mbWfZx249wQaNCNY_c6D838KX-jBf2YjI-97RVoQhdfFR8UVCH0jBtQGpNqktnME1Z5QbQpPfGF5Mxp4dKYG_DwqBidsA9jPt5Av_q3MOFaZW8To6GuGhvOyLeBhwCUgH-Xr8--k5A1KnhX-xQaLSz23fInbNlmr_bewfw-z_Pd98dvR6TLKkAssJM54ZUwqc-dZ8JlOsut9NJZWMUKyQxYdMeMp4bZSuRO6-CYNlanprA8zayrKgr9XkKXYeFNg0aJsRjOdEK0dclY9zYnpXJ7xqIlAh5FoOuiJMXa-hfTBPyL2_59RfMPP21c_nZvoOsdb8VvWqDdRBuuvoWutJksl7fRx_bBr-9OAHHjsYdPcN38cBOsVxiYQfkU75DgMMDaLuYOT5aAqMYAjYe-8cQtvmr37VTjcOv9Djq5EOneRZt1U7v7CFsuK8c9LamBXR_1WhfQFOyL5yWjgico6yWpbBfQPOTVmKjoWKdStdJXIH0Vpa-KBL0Yvjlrw3mc23onTNDQMoTijgXN9LPqNFt5B5tGz6Wj1jAu0lLrFH47XHS1HranCdrqp1d19mGmVmhO0NOhGjQ7SF_XrlnENlIEegdt7rVoGEYCxcAyKNSINZysDXW9pj79EqOHF1IIIM0JetkjajWs_4viwfl_8QRdHR0fHqiDvaP9h-haHgGfkZxvoc35dOEeAXObm8dRXTD6dNH6-Rt_21dp
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKEYgL4k2ggJHgBNYmsR07B4QoZdVSqDhQsTfXdmxadUnKPkD71_h1jJ1kV8ujt17tieWMZ8afPeMZhJ5xA0pjUk0ym3nCKi-INqUnvpCcOS1cGmsDfjwodg_Z-xEfbaBf_VuYEFbZ28RoqKvGhjvyAeAQECXA3-XAd2ERn3aGr8--k1BBKnha-3IarYjsu8VPOL5NX-3twFo_z_Phu89vd0lXYYBYQCozwithUp87z4TLdJZb6aWzsKMVkhmw7o4ZTw2zlcid1sFJbaxOTWF5mllXVRTGvYQuC8qzoGNiJJb3OyHzumSse6eTUjmYsmiVAFMRGLooSbG2F8aSAf_CuX-Ha_7hs41b4fAGut5hWPymFbqbaMPVt9CVtqrl4jb60j7-9d1tIG489vAJrpsfboz1Sh6m0D7B2yQ4D7C285nD4wVIV2MA0sPYeOzmp9p9O9E4RMDfQYcXwt27aLNuancfYctl5binJTVwAqRe6wJIwdZ4XjIqeIKynpPKdsnNQ42NsYpOdipVy30F3FeR-6pI0IvlN2dtao9zqbfDAi0pQ1ru2NBMvqpOy5V3cID0XDpqDeMiLbVO4bdD0Kv1cFRN0Fa_vKqzFVO1kuwEPV12g5YH7uvaNfNII0WAekBzr5WG5UygGRAHhR6xJidrU13vqU-OYybxQgoBADpBL3uJWk3r_6x4cP5fPEFXQTPVh72D_YfoWh7lPSM530Kbs8ncPQIQNzOPo7ZgdHTR6vkbdURbnw
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Identification+of+four+novel+associations+for+B-cell+acute+lymphoblastic+leukaemia+risk&rft.jtitle=Nature+communications&rft.au=Vijayakrishnan%2C+Jayaram&rft.au=Qian%2C+Maoxiang&rft.au=Studd%2C+James+B.&rft.au=Yang%2C+Wenjian&rft.date=2019-11-25&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=10&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-019-13069-6&rft.externalDocID=10_1038_s41467_019_13069_6
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon