Depletion of central memory CD8+ T cells might impede the antitumor therapeutic effect of Mogamulizumab

• Published in: Nature communications Vol. 12; no. 1; pp. 7280 - 13
• Main Authors: Maeda, Yuka, Wada, Hisashi, Sugiyama, Daisuke, Saito, Takuro, Irie, Takuma, Itahashi, Kota, Minoura, Kodai, Suzuki, Susumu, Kojima, Takashi, Kakimi, Kazuhiro, Nakajima, Jun, Funakoshi, Takeru, Iida, Shinsuke, Oka, Mikio, Shimamura, Teppei, Doi, Toshihiko, Doki, Yuichiro, Nakayama, Eiichi, Ueda, Ryuzo, Nishikawa, Hiroyoshi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 631/250/251/1574; 631/67/580/1884/2323; 692/4017; 692/4028/67/1059/2325; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized - therapeutic use; Anticancer properties; Antineoplastic Agents - therapeutic use; Antitumor activity; Cancer; CD8 antigen; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - metabolism; Cell differentiation; Chemokine receptors; Depletion; Dose-Response Relationship, Drug; Effector cells; Female; Homeostasis; Humanities and Social Sciences; Humans; Immune response; Immune system; Immunological memory; Immunoregulation; Immunotherapy; Killer Cells, Natural - drug effects; Killer Cells, Natural - metabolism; Lymphocytes; Lymphocytes T; Male; Memory cells; Memory T Cells - drug effects; Middle Aged; Monoclonal antibodies; multidisciplinary; Neoplasms - drug therapy; Neoplasms - immunology; Patients; Phenotypes; Receptors, CCR4 - antagonists & inhibitors; Receptors, CCR4 - metabolism; Science; Science (multidisciplinary); Solid tumors; T-Lymphocytes, Regulatory - drug effects; T-Lymphocytes, Regulatory - metabolism; Targeted cancer therapy; Treatment Outcome

Regulatory T (Treg) cells are important negative regulators of immune homeostasis, but in cancers they tone down the anti-tumor immune response. They are distinguished by high expression levels of the chemokine receptor CCR4, hence their targeting by the anti-CCR4 monoclonal antibody mogamulizumab h...