Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients

• Published in: Scientific reports Vol. 9; no. 1; p. 8379
• Main Authors: Corrêa, Jôice Dias, Fernandes, Gabriel R., Calderaro, Débora Cerqueira, Mendonça, Santuza Maria Souza, Silva, Janine Mayra, Albiero, Mayra Laino, Cunha, Fernando Q., Xiao, E., Ferreira, Gilda Aparecida, Teixeira, Antônio Lúcio, Mukherjee, Chiranjit, Leys, Eugene J., Silva, Tarcília Aparecida, Graves, Dana T.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.06.2019; Nature Publishing Group
• Subjects: 13/21; 45/22; 45/23; 45/47; 45/77; 631/326; 692/4023/1670/498; 692/700/3032/3149; Adult; Anti-Citrullinated Protein Antibodies - genetics; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - microbiology; Arthritis, Rheumatoid - pathology; Autoimmune diseases; Citrulline; Cytokines - genetics; Dental plaque; Dysbacteriosis; Dysbiosis - complications; Dysbiosis - genetics; Dysbiosis - microbiology; Dysbiosis - pathology; Female; Humanities and Social Sciences; Humans; Inflammation; Interleukin 17; Interleukin 2; Interleukin-17 - genetics; Joint diseases; Male; Microbiota; Microbiota - genetics; Microorganisms; Middle Aged; Mouth - microbiology; Mouth - pathology; multidisciplinary; Next-generation sequencing; Patients; Periodontal diseases; Periodontitis; Periodontitis - complications; Periodontitis - genetics; Periodontitis - microbiology; Periodontitis - pathology; Periodontium - microbiology; Periodontium - pathology; Rheumatoid arthritis; Rheumatoid factor; RNA, Ribosomal, 16S - genetics; rRNA 16S; Science; Science (multidisciplinary); Tumor necrosis factor; γ-Interferon

Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation. Individuals with RA have a higher risk of periodontitis and periodontitis has been linked to RA through the production of enzymes by periodontal pathogens that citrullinate proteins. This linkage is supported by...