Multimodal single-cell analyses of peripheral blood mononuclear cells of COVID-19 patients in Japan

• Published in: Scientific reports Vol. 13; no. 1; pp. 1935 - 10
• Main Authors: Kashima, Yukie, Mizutani, Taketoshi, Nakayama-Hosoya, Kaori, Moriyama, Saya, Matsumura, Takayuki, Yoshimura, Yoshihiro, Sasaki, Hiroaki, Horiuchi, Hiroshi, Miyata, Nobuyuki, Miyazaki, Kazuhito, Tachikawa, Natsuo, Takahashi, Yoshimasa, Suzuki, Tadaki, Sugano, Sumio, Matano, Tetsuro, Kawana-Tachikawa, Ai, Suzuki, Yutaka
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.02.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647/514/2254; 631/250/255/2514; 692/420/254; Aged; Antibody response; Coronaviruses; COVID-19; Gene expression; Humanities and Social Sciences; Humans; Immune clearance; Japan - epidemiology; Leukocytes, Mononuclear; Lymphocytes; Lymphocytes T; Medical personnel; multidisciplinary; Patients; Peripheral blood mononuclear cells; Receptors, Antigen, T-Cell; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Single-Cell Analysis; T cell receptors; Transcriptomes; Japan

SARS-CoV-2 continues to spread worldwide. Patients with COVID-19 show distinct clinical symptoms. Although many studies have reported various causes for the diversity of symptoms, the underlying mechanisms are not fully understood. Peripheral blood mononuclear cells from COVID-19 patients were colle...