Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease

• Published in: Cell death and differentiation Vol. 28; no. 5; pp. 1548 - 1562
• Main Authors: Bao, Wen-Dai, Pang, Pei, Zhou, Xiao-Ting, Hu, Fan, Xiong, Wan, Chen, Kai, Wang, Jing, Wang, Fudi, Xie, Dong, Hu, Ya-Zhuo, Han, Zhi-Tao, Zhang, Hong-Hong, Wang, Wang-Xia, Nelson, Peter T., Chen, Jian-Guo, Lu, Youming, Man, Heng-Ye, Liu, Dan, Zhu, Ling-Qiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.05.2021; Nature Publishing Group
• Subjects: 13/1; 13/105; 13/89; 13/95; 14/19; 14/28; 38/22; 38/77; 38/90; 59/57; 631/378/2611; 631/443/7; 64/110; 64/60; 82/29; 82/51; Alzheimer Disease - genetics; Alzheimer's disease; Animals; Apoptosis; Atrophy; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Cell death; Cognitive ability; Disease Models, Animal; Ferroptosis; Ferroptosis - physiology; Gene set enrichment analysis; Hippocampus; Homeostasis; Humans; Iron; Life Sciences; Memory; Memory Disorders - genetics; Mice; Neocortex; Neurodegenerative diseases; Physical characteristics; Stem Cells

Iron homeostasis disturbance has been implicated in Alzheimer’s disease (AD), and excess iron exacerbates oxidative damage and cognitive defects. Ferroptosis is a nonapoptotic form of cell death dependent upon intracellular iron. However, the involvement of ferroptosis in the pathogenesis of AD rema...